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330 Chapter 6: Breast Cancer 33. Overmeyer BA: Ifosfamide in the treatment of breast cancer. Semin Oncol 23 (Suppl 6):38-41, 1996. 34. Druckrey H: Krebs-experimentelle Ursachen forschung und chemothrapie. Z Krebsgeschehen 5:73-79, 1973. 35. Boal JH, Williamson M, Boyd VL, Ludeman SM, Egan W: 31 P NMR studies of the kinet ics of bisalkylation by isophosphoramide mustard: Comparisons with phosphoramide mus tard. J Med Chem 32:1768-1773, 1989. 36. Goldin A: Ifosfamide in experimental tumor systems. Semin Oncol 9 (Suppl l):14-23, 1982. 37. Berger DP, Fiebig HH, Winterhalter BR, Wallbrecher E, Henss H: Preclinical phase II study of ifosfamide in human tumour xenografts in vivo. Cancer Chemother Pharmacol 26 (Suppl):S7-Sll, 1990. 38. Wolff SN, Herzig RH, Fay JW, LeMaistre CF, Brown RA, Frei-LahrD, et al.: High-dose A^/V9,M)-triethylenethiophosphoramide (thiotepa) with autologous bone marrow trans plantation: Phase I studies. Semin Oncol 17 (Suppl 3):2-6, 1990. - 39. Elfenbein GJ, Perkins JB, Fields KK, Ballester OF, Goldstein SC, Hiemenz KW, et al.: Hematologic recovery after high dose taxol, novantrone, thiotepa (TNT) and autologous stem cell transplant: Evaluation of the effects of stem cell source and Taxol (Abstract). Blood 86:707a, 1995. 40. Kusminsky G, Zylberman M, Foncuberta MC, Dictar M, Salum G, Morero JL, et al.: Pulmonary toxicity of high-dose thiotepa containing regimens in breast cancer patients undergoing autologous hematopoietic transplant (Abstract). Blood 88 (Suppl l):257b, 1996. 41. Murphy B, Raptis G, Tiersten A, Hamilton N, Hudis C, Gilewski T, et al.: Phase I/II trial of sequential, rapidly administered high-dose cyclophosphamide + paclitaxel followed by thiotepa + paclitaxel in metastatic breast cancer patients (Abstract). Proc Am Soc Clin Oncol 16:369, 1997. 42. Anelli A, Rocha AP, Gadeha AP, Tabacof J, Feher O, Cruz SM, et al.: Phase II trial of sequential high-dose chemotherapy with carboplatin and escalating doses of paclitaxel with G-CSF primed PBSC rescue in patients with metastatic breast cancer: Preliminary results (Abstract). Proc Am Soc Clin Oncol 16:424, 1997. 43. Mehra R, Browne V, Rondon G, Mirza N, Champlin R: Phase I/II study of multiple course high-dose CTC with PBSC infusion for metastatic breast cancer (Abstract). Proc Am Soc Clin Oncol 16:351, 1997. 44. Broun ER, Petruska PJ, Dunphy FR, Velesquez WV, Pincus S, Mclntyre W, et al.: Taxol plus carboplatin/cyclophosphamide and peripheral blood stem cell support in stage II/III breast cancer (Abstract). Proc Am Soc Clin Oncol 15:1002, 1996. 45. Winer E, Berry D, Duggan D, Henderson IC, Cirrincione C, Cooper R, et al.: Failure of higher dose paclitaxel to improve outcome in patients with metastatic breast cancer: Results from CALGB 9342 (Abstract). Proc Am Soc Clin Oncol 17:101a, 1998. 46. Basser R, To LB, Begley CG, Juttner CA, Mäher DW, Szer J, et al.: Adjuvant treatment of high-risk breast cancer using multiple high-dose chemotherapy and filgrastim-mobi- lized peripheral blood progenitor cells. Clin Cancer Res 1:715-721, 1995. 47. Ayash L, Elias AD, Schwartz G, Wheeler C, Ibrahim J, Teicher BA, et al.: Double dose-
Prince et al. intensive chemotherapy with autologous stem-cell support for metastatic breast cancer: No improvement in progression-free survival by the sequence of high-dose melphalan fol lowed by cyclophosphamide, thiotepa, and carboplatin. J Clin Oncol 14:2984-2992, 1996. 48. Ghalie R, Williams SF, Valentino LA, Feingold J, Korenblit AD, Adler SS, et al.: Tandem peripheral blood progenitor cell transplants as initial therapy for metastatic breast cancer. Biol Blood Marrow Transplant 1:40-46, 1995. 49. Crown J, Raptis G, Vahdat L, et al.: Rapid administration of sequential high dose cyclophosphamide, melphalan, thiotepa supported by filgrastim + peripheral blood prog enitors in patients with metastatic breast cancer: A novel and very active treatment strat egy (Abstract). Proc Am SocClinOncol 13:110, 1994. 50. Crown J, Vahdat L, Raptis G, et al.: Rapidly cycled courses of high-dose chemotherapy supported by filgrastim and peripheral blood progenitors in patients with metastatic breast cancer (Abstract). Proc Am SocClinOncol 13:110, 1994. 51. Bitran JD, Samuels B, Klein L, Hanauer S, Johnson L, Martinec J, et al.: Tandem high- dose chemotherapy supported by hematopoietic progenitor cells yields prolonged survival in stage IV breast cancer. Bone Marrow Transplant 17:157-162,1996. 52. Prince HM, Imrie K, Keating A, Goss PE, Stewart AK, Crump M: Cyclophosphamide, adriamycin, 5 fluorouracil and G-CSF mobilization achieves high peripheral blood prog enitor cell yield which can support multiple cycles of high-dose chemotherapy (Abstract). Blood 86 (Suppl l):404a, 1995. 53. Gianni S, Siena S, Bregni M, Di Nicola M, Orefice S, Cusumano F, et al.: Efficacy, tox icity and applicability of high-dose sequential chemotherapy as adjuvant treatment in oper able breast cancer with 10 or more involved axillary nodes: Five-year results. J Clin Oncol 15:2312-2321,1997. 54. Frick M, Nitz U, Adomeit A, Mezger J, Eimermacher H, Westerhausen M: Tandem high- dose chemotherapy in 58 patients with high risk breast cancer: Interim analysis from a multicenter phase II and phase III study (Abstract). Proc Am Soc Clin Oncol 16:321,1997. 331
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AUTOLOGOUS BLOOD AND MARROW TRANSPL
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AUTOLOGOUS BLOOD AND MARROW TRANSPL
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ACKNOWLEDGMENTS We wish to thank Wi
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THE VAN BEKKUM STEM CELL AWARD Prof
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xii Table of Contents CHAPTER 2: AL
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xiv Table of Contents Late Non-Rela
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xvi Table of Contents Pretreatment
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xviii Table of Contents CHAPTER 7:
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XX Table of Contents Long-Term Obse
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xxii Table of Contents CHAPTER 13:
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0-9 LIST OF ABBREVIATIONS 2CDA 2-ch
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List of Abbreviations xxvii EFS eve
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List of Abbreviations MOPP mechlore
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VOD veno-occlusive disease VPC viru
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4HC-Purged Autologous Stem Cell Tra
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1.0-1 + 0.2 Miller et al. 5 Event F
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Miller et al. Adjusted probability
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Who Benefits From Autograft in AML
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Burnett 11 which to set the transpl
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Table 1. Outcome after relapse in M
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Immunotherapy in AML: No Positive E
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Simonsson et al. inhibit IL-2 induc
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Autologous Bone Marrow Transplantat
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Ball et al. 21 CD15) and AML-2-23 (
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Ball et al. 23 The ex vivo treatmen
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Ball et al. 25 Table 2. Factors inv
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Ball et al. Overall Survival for Pa
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Ball et al. Overall Survival for Pa
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Ball et al. 31 Overall Survival for
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Ball et al. Table 4. Actuarial over
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Ball et al. myeloid leukemia. The G
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Ball et al. 1993. 38. Mehta J, Powl
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Can Autologous Stem Cell Transplant
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De Witte et al. 41 novo AML. Auer r
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De Witte et al. hematopoietic engra
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De Witte et al. 23. Fenaux P, Laï
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Stein et al. and fever. No patient
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Stein et al. after doses 1, 3, and
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Stein et al. early after the transp
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autologous stem-cell rescue. / Clin
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Bone Marrow Transplantation for Acu
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Table 2. Autologous BMT in ALL in f
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Rowe 61 or adult patients with acut
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Hoelzer and Gôkbuget minitransplan
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Hoelzer and Gdkbuget 65 blood, earl
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Table 3. Risk factors for the defin
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Hoelzer and Gôkbuget treatment opt
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Hoeker and Gökbuget tical sibling
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Sierra et al. INTRODUCTION Two-thir
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Sierra et al. Table 2. Adverse char
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1,0 0,0 J Sierra et al. 0 20 40 60
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Sierra et al. Months Figure 4 < 30,
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Sierra et al. No adverse factors (n
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1994. Sierra et al. 83 10. Canals C
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Martin, Atta, and Hoelzer 85 adult
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Martin, Atta, and Hoelzer 87 Single
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100. Martin, Atta, and Hoelzer 89 P
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Martin, Atta, and Hoelzer 91 chromo
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Autologous vs. Unrelated Allogeneic
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Boyer and Yeager 95 outcomes after
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Boyer and Y eager 97 Table 2. Hypot
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Boyer and Y eager SUMMARY Most of t
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CHAPTER 3 CML
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Autograft Followed by Allograft Wit
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106 Chapter 3: CML (one low-grade a
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108 Chapter 3: CML DISCUSSION Myelo
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110 Chapter 3: CML Philadelphia-neg
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The Case for Manipulation of CML Au
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Toward a Cure by Drug Treatment? Th
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116 Chapter 3 :CML Table 1. Prolong
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118 Chapter 3: CML Table 3. German
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120 Chapter 3: CML Table 5. Normal
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122 Chapter 3: CML Table 8. Surviva
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124 Chapter 3: CML 88:3118-3122, 19
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126 Chapter 3: CML RK, Klingemann H
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The Tyrphostin AG957 Inhibits the I
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130 Chapter 3: CML mobilization. Al
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132 Chapter 3: CML A B 100 n 0 1 5
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134 Chapter 3: CML The in vitro sel
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136 Chapter 3: CML detecting leukem
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Progressive Hodglcin's Lymphoma Fol
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Reece et al. survival is observed i
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0.2 -I 0.0 0 Reece et al. 143 ii i
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Reece et al. Table 3. Causes of non
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Reece et al. carmustine, etoposide
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CD34 + Selection of Hematopoietic B
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Lazarus et al. 151 significantly de
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Lazarus et al. 153 (Sigma, St Louis
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Lazarus et al. 155 Table 2. Effect
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Lazarus et al. 157 difference. Furt
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Lazarus et al. 159 cells after myel
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The European CUP/UP Trial: A Prelim
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Table 1. Patient characteristics at
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Schouten et al. licular non-Hodgkin
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Sweetenham et al. vs. autologous pe
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Table 1. Patient characteristics, g
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Table 2. Patient characteristics, g
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Table 3. Sites of relapse, group A
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Table 4. Patterns of relapse, group
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A 100 80 %OS 60 40 20 B 100 %OS | S
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Sweetenham et al. new sites, and fi
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Sweetenham et al. Treatment options
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Molecular Remission: A Worthwhile A
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Early or Late Autotransplant in Hig
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Schenkein et al. 187 PATIENTS AND M
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Schenkein et al. 189 Toxicity Toxic
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Schenkein et al. 191 16. Glick JH,
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Santini et al. 193 to evaluate the
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Table 1. Continued Santini et al. 1
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Santini et al. 197 cytosine arabino
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1 0 0 1 90- 80- 70- (0 u. 60' o so-
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Hodgkin's lymphoma. N EnglJ Med 333
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CHAPTER 5 MYELOMA
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206 Chapter 5: Myeloma independent
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208 Chapter 5: Myeloma disease (MRD
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210 Chapter 5: Myeloma Scandinavia,
Page 246 and 247:
212 Chapter 5: Myeloma (0 n o B co
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214 Chapter 5: Myeloma B cq d ? o c
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216 Chapter 5: Myeloma patients wit
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218 Chapter 5: Myeloma PBSC transpl
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220 Chapter 5: Myeloma 25. Seiden M
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Autologous Transplantation in Multi
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224 Chapter 5: Myeloma 0 52 44 U §
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226 Chapter 5: Myeloma BM ^ (CD34±
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228 Chapter 5: Myeloma IFM 94 : OS
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230 Chapter 5: Myeloma two groups a
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232 Chapter 5: Myeloma increase bot
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234 Chapter 5: Myeloma REFERENCES 1
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236 Chapter 5: Myeloma Intensified
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238 Chapter 5: Myeloma of CD34 + ce
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Chapter 5: Myeloma Table 2. Descrip
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242 Chapter 5: Myeloma o 8H 0 2 4 6
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244 Chapter 5: Myeloma ated with sh
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The Presence of Micrometastases in
Page 283 and 284:
Kvalheim et al. 249 Table 1. Immuno
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Kvalheim et al. 251 Figure 1. Sixty
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Kvalheim et al. 253 DISCUSSION In t
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Kvalheim et al. 255 Bastert G: Micr
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Hood et al. 257 In an effort to inc
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#CD34 + cells in blood = Hood et al
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Hood et al. 261 Table 3. Frequency
Page 297 and 298:
Hood et al. 263 REFERENCES 1. Rill
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The Clinical Significance of Breast
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Moss et al. tests, and bilateral po
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Moss et al. 269 0 15 70 143 200 400
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Moss et al. 271 0 3 6 12 18 24 30 3
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Moss et al. 273 8. Passos-Coelho J,
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Autotransplantation for Men With Br
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McCarthy et al. 277 radiation, two
Page 313 and 314: High Dose Sequential Chemotherapy W
Page 315 and 316: Viens et al. 281 3 g/m 2 and doxoru
Page 317 and 318: Table 1. Tumor characteristics Exte
Page 319 and 320: Table 4. Response Viens et al. 285
Page 321 and 322: Viens et al. 287 Table 5. Pathologi
Page 323 and 324: Viens et al. 289 apy for inoperable
Page 325 and 326: Gliick et al. 291 INTRODUCTION The
Page 327 and 328: Gluck et al. 293 RESULTS Patient de
Page 329 and 330: Glück et al. 295 Table 3. Response
Page 331 and 332: Gluck et al. 297 Overall Survival O
Page 333 and 334: Gluck et al. 299 Sudbury patients w
Page 335 and 336: Gluck et al. 301 anthracycline or t
Page 337 and 338: Repetitive High-Dose Therapy With P
Page 339 and 340: Prince et al. paramagnetic separati
Page 341 and 342: Prince et al. Table 1. High-dose re
Page 343 and 344: Table 2. Patient characteristics (n
Page 345 and 346: Table 4. Hematopoietic recovery fol
Page 347 and 348: 1.0- M C .S 0.8- a c *fe o o> 0.6-
Page 349 and 350: M 1.0 I 0.8H s? VI o.6H S 0.2 0.0 P
Page 351 and 352: a Prince et al. days to platelets >
Page 353 and 354: Table 5. Results of Isolex 300i CD3
Page 355 and 356: Prince et al. 321 Figure 5, continu
Page 357 and 358: Prince et al. 323 months after tran
Page 359 and 360: Prince et al. 325 excessive to be u
Page 361 and 362: Prince et al. 327 eight patients ha
Page 363: Prince et al. 329 marrow transplant
Page 367 and 368: -Q CO .Q O 1.0 0.9 0.8 0.7 0.6 0.5
Page 369 and 370: .Q CD .Q O 1.0 0.9 0.8 0.7 0.6 0.5
Page 371 and 372: oba Q. 1.0 0.9 Dicke et al. Stage I
Page 373 and 374: Vahdat with peripheral blood progen
Page 375 and 376: Evaluation of Prognostic Factors fo
Page 377 and 378: Fields et al. 343 PATIENTS AND METH
Page 379 and 380: Table 1. Chemotherapy regimens. Fie
Page 381 and 382: Fields et al. Stage II; 4-9 Pos LN
Page 383 and 384: U U Fields et al.
Page 385 and 386: Fields et al. 351 between 1 and 2 y
Page 387 and 388: European Trends and the EBMT Databa
Page 389 and 390: 25% % 22% / 17% \ Rosti et al. 355
Page 391 and 392: Rosti et al. 357 The new Italian St
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Page 395 and 396: Rosti et al. 6. Haas R, Schmid H, H
Page 397 and 398: Bewick et al. 363 INTRODUCTION The
Page 399 and 400: Bewick et al. 365 Blood samples obt
Page 401 and 402: Bewick et al. 367 HDCT with ABSC su
Page 403 and 404: Bewick et al. Progression Free Surv
Page 405 and 406: Bewick et al. pression in MBC, i.e.
Page 407 and 408: Bewick et al. 14. Kandl HL, Seymour
Page 409: CHAPTER 7 OTHER SOLID TUMORS
Page 412 and 413: 378 Chapter 7: Solid Tumors INTRODU
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380 Chapter 7: Solid Tumors Prepara
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382 Chapter 7: Solid Tumors Surviva
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384 Chapter 7: Solid Tumors months
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386 Chapter 7: Solid Tumors have be
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High-Dose Chemotherapy in the Manag
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390 Chapter 7: Solid Tumors followe
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392 Chapter 7: Solid Tumors Table 1
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394 Chapter 7: Solid Tumors (mucosi
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Three-Fold Intensification by Seque
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High-Dose Therapy for Small Cell Lu
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404 Chapter 7: Solid Tumors chemoth
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406 Chapter 7: Solid Tumors SCLC ha
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408 Chapter 7: Solid Tumors relapse
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410 Chapter 7: Solid Tumors 69:585-
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412 Chapter 7: Solid Tumors ogous b
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414 Chapter 7: Solid Tumors 64. Bru
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416 Chapter 7: Solid Tumors Prignot
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418 Chapter 7: Solid Tumors CO > CO
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420 Chapter 7: Solid Tumors TANDEM
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Multiple Courses of Cyclophosphamid
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424 Chapter 7: Solid Tumors and the
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426 Chapter 7: Solid Tumors Thiotep
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Page 464 and 465:
430 Chapter 7: Solid Tumors E 100 0
Page 466 and 467:
432 Chapter 7: Solid Tumors course
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434 Chapter 7: Solid Tumors boplati
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436 Chapter 7: Solid Tumors INTRODU
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438 - Chapter 7: Solid Tumors Table
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440 Chapter 7: Solid Tumors seeded
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442 Chapter 7: Solid Tumors DISCUSS
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444 Chapter 7: Solid Tumors 10. Di
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446 Chapter 7: Solid Tumors plasma
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Autologous Stem Cell Transplantatio
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Keystone 451 hypertension, anemia,
Page 487 and 488:
Fassas et al. 453 INTRODUCTION Mult
Page 489 and 490:
Fassas et al. Table 2. Stem cell mo
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Table 3. Toxicity after stem cell i
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Fassas et al. Table 5. Trial 1: cha
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Fassas et al. MS PROGRESSION FREE S
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Fassas et al. ic or autologous bone
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1 2 1 6 EAE. Burt et al. 465 Becaus
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Burt et al. Since cyclophosphamide
Page 503 and 504:
Burt et al. 469 toxicity study, we
Page 505 and 506:
Burt et dl. All 23. Mor F, Cohen IR
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Hasler, Gratwohl, and Tyndall an ev
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Hasler, Gratwohl, and Tyndall 475 B
Page 511 and 512:
Kuis, Wulffraat, and Sanders 477 st
Page 513 and 514:
Kuis, Wulffraat, and Sanders neousl
Page 515:
CHAPTER 9 LONG-TERM EFFECTS
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484 Chapter 9: Long-Term Effects po
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486 Chapter 9: Long-Term Effects Ta
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488 Chapter 9: Long-Term Effects ml
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490 Chapter 9: Long-Term Effects 4.
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492 Chapter 9: Long-Term Effects us
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494 Chapter 9: Long-Term Effects AB
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Page 532 and 533:
498 Chapter 9: Long-Term Effects En
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500 Chapter 9: Long-Term Effects Rl
Page 536 and 537:
502 Chapter 9: Long-Term Effects RE
Page 538 and 539:
504 Chapter 9: Long-Term Effects A,
Page 540 and 541:
Long-Term Follow-Up of Autologous T
Page 542 and 543:
Page 545:
CHAPTER 10 GRAFT MANIPULATION
Page 548 and 549:
514 Chapter 10: Graft Manipulation
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Stem Cell Reinfusion Over Two Conse
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Page 614 and 615:
Final Report of the First Prospecti
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Page 635 and 636:
Canine Hematopoietic Stem Allograft
Page 637 and 638:
Sandmaier et al. 603 The resultant
Page 639 and 640:
Sandmaier et al. 605 synthesis path
Page 641 and 642:
Sandmaier et al. 607 interactions o
Page 643 and 644:
Sandmaier et al. 1991. 2. Burchenal
Page 645 and 646:
87:3508-3513,1996. Sandmaier et al.
Page 647 and 648:
Giralt, Khouri, and Champlin Table
Page 649 and 650:
Giralt, Khouri, and Champlin seven
Page 651 and 652:
1.0 3 0.2 Giralt, Khouri, and Champ
Page 653:
CHAPTER 12 GENE THERAPY
Page 656 and 657:
622 Chapter 12: Gene Therapy INTROD
Page 658 and 659:
624 Chapter 12: Gene Therapy RESULT
Page 660 and 661:
626 Chapter 12: Gene Therapy envisi
Page 662 and 663:
628 Chapter 12: Gene Therapy cer in
Page 664 and 665:
A Vaccine of Melanoma Peptide Loade
Page 667 and 668:
B43(anti-CD 19)-Gen i stein Immunot
Page 669 and 670:
Targeting Immunotherapy for the Tre
Page 671 and 672:
McGuinness andArceci 637 modified m
Page 673 and 674:
McGuinness andArceci 639 leukemic c
Page 675 and 676:
McGuinness and Arced 641 in G418. T
Page 677 and 678:
McGuinness andArceci 643 Figure 2
Page 679 and 680:
mRNA for hB7-1 (1491 bp) mRNA for C
Page 681 and 682:
McGuinness and Arced CD80PE C080PE
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McGuinness andArceci 649 8. Robert
Page 685 and 686:
McGuinness andArceci immune respons
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McGuinness andArceci 75. Jubinsky F
Page 689 and 690:
Slavin et al. 655 up suggests, as p
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Slavin et al. 657 was a phase lib c
Page 693 and 694:
Slavin et al. presented, appears to
Page 695 and 696:
Antitumor Immunotherapy in Autologo
Page 697 and 698:
Klingemann et al. 663 Table 3. Meth
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CHAPTER 14 RADIOIMMUNOTHERAPY
Page 702 and 703:
668 Chapter 14: Radioimmunotherapy
Page 704 and 705:
Page 706 and 707:
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Page 710 and 711:
Page 712 and 713:
Page 714 and 715:
Selection of Radioisotopes, Chelate
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Page 726 and 727:
Radioimmunotherapy of Common Epithe
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CHAPTER 15 NEW AVENUES
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698 Chapter 15: New Avenues Table 1
Page 734 and 735:
700 Chapter 15: New Avenues An alte
Page 736 and 737:
702 Chapter 15: New Avenues who can
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704 Chapter 15: New Avenues myeloid
Page 740 and 741:
706 Chapter 15: New Avenues 48. Gir
Page 742 and 743:
Emerging Viral Infections in Blood
Page 744 and 745:
710 Chapter 15: New Avenues influen
Page 746 and 747:
712 Chapter 15: New Avenues Among a
Page 748 and 749:
714 Chapter 15: New Avenues physica
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716 Chapter 15: New Avenues respira
Page 752 and 753:
Minimal Therapy Models of Transplan
Page 755:
CHAPTER 16 SUMMARIES
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724 Chapter 16: Summaries although
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726 Chapter 16: Summaries use of po
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728 Chapter 16: Summaries Table 1.
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736 Chapter 16: Summaries IL-15. Th
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738 Chapter 16: Summaries Patterns
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740 List of Participants Thomas L.
Page 776 and 777:
742 List of Participants Sergio A.
Page 778 and 779:
744 List of Participants Hans Marti
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746 List of Participants David P. S
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748 List of Participants AUTHOR IND
Page 784 and 785:
750 Author Index Hurd, D.D. 483 Kui
Page 786 and 787:
752 Author Index Stiff, Patrick J.
Page 788 and 789:
754 Key Word Index Hematologic mali
Page 792:
ISBN 1-891524-04-6
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