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xviii Table of Contents CHAPTER 7: SOLID TUMORS Conventional Therapy and Future Directions 377 Patrick J. Stiff, Christine Kerger, Robert A. Bayer High-Dose Chemotherapy in the Management of Germ 388 Cell Tumors Rafat Abonour, Kenneth Cornetta, Craig R. Nichols, Lawrence Einhorn Three-Fold Intensification by Sequential High-Dose 396 Chemotherapy for Small Cell Lung Cancer: A Multicenter Phase II Study S. Leyvraz, L. Perey, G. Rosti, A. Lange, L. Bosquée, F. Pasini, Y. Humblet, O. Hamdan,.S. Pampallona High-Dose Therapy for Small Cell Lung Cancer With Stem 402 Cell Support Anthony Elias Transplantation With PBSC, Manipulated or 417 Unmanipulated, for the Treatment of Childhood Cancer Yoichi Takaue, Haruhiko Eguchi, Yoshifumi Kawano, Arata Watanabe, Hideo Mugishima, Michio Kaneko Multiple Courses of Cyclophosphamide, Thiotepa, and 422 Carboplatin: Managing Toxicity by Dose Reduction and Pharmacokinetic Monitoring Sjoerd Rodenhuis, Alwin D.R. Huitema, Joke W. Baars, Anneke Westermann, Marjo M.J. Holtkamp, Jan H. Schornagel, Jos H. Beijnen Epirubicin Plus G-CSF-Elicited Peripheral Blood Progenitor 435 Cell Mobilization Is Significantly Enhanced by Amifostine Carmelo Carlo-Stella, Anna Dodero, Daniela Garau, Ester Regazzi, Lina Mangoni, Vittorio Franciosi, Beatrice Di Blasio, Rodolfo Passalacqua, Giorgio Cocconi, Vittorio Rizzoli CHAPTER 8: AUTOIMMUNE DISEASE Autologous Stem Cell Transplantation for Autoimmune 449 Diseases: Clinical Indications Edward C. Keystone
Table of Contents Autologous Blood Stem Cell Therapy for Progressive Multiple Sclerosis Athanasius Fassas, Achilles Anagnostopoulos, Aristide Kazis, Konstantin Kapinas, Ioanna Sakellari, Vassiiis Kimiskidis, Evangelia Yannaki Hematopoietic Stem Cell Transplantation of Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Multipd Sclerosis Richard K Burt, Jakub Stefka, Dong Cheng, Alexandra Roginsky, Steven Rosen, Ann Traynor Autologous Stem Cell Therapy in Autoimmune Disease: Follow-Up of Cases and Issues Raised by the EBMT/EULAR Databank Paul Hasler, Alois Gratwohl, Alan Tyndall Autologous Hematopoietic Stem Cell Transplantation: An Alternative for Refractory Juvenile Chronic Arthritis Wietse Kuis, Nico M. Wulffraat, Lieke (E.) A.M. Sanders CHAPTER 9: LONG-TERM EFFECTS Presence in Pretransplant Marrow of Abnormal Progenitor Cell Clones That Give Rise to Posttransplant Myelodysplasia: Implications for High-Dose Chemoradiotherapy With Autologous Hematopoietic Cell Transplantation J.E. Radford Jr., E.A. Abruzzese, M.J. Pettenati, P.N. Rao, R.O. Rainer, J.J. Perry, J.M. Cruz, B.L. Powell, J.S. Miller, J.J. Vredenburgh, S. Amadori, D.D. Hurd Importance of Marrow Doses and Modelization of Engraftment and Outcome in 229 Patients With Acute Leukemia Autografted With Marrow Purged by Mafosfamide in a Single Institution N.C. Gorin Long-Term Follow-Up of Autologous Transplant Patients London Experience Powles RL
Page 1: AUTOLOGOUS BLOOD AND MARROW TRANSPL
Page 5 and 6: AUTOLOGOUS BLOOD AND MARROW TRANSPL
Page 7: ACKNOWLEDGMENTS We wish to thank Wi
Page 11: THE VAN BEKKUM STEM CELL AWARD Prof
Page 14 and 15: xii Table of Contents CHAPTER 2: AL
Page 16 and 17: xiv Table of Contents Late Non-Rela
Page 18 and 19: xvi Table of Contents Pretreatment
Page 22 and 23: XX Table of Contents Long-Term Obse
Page 24 and 25: xxii Table of Contents CHAPTER 13:
Page 27 and 28: 0-9 LIST OF ABBREVIATIONS 2CDA 2-ch
Page 29 and 30: List of Abbreviations xxvii EFS eve
Page 31 and 32: List of Abbreviations MOPP mechlore
Page 33: VOD veno-occlusive disease VPC viru
Page 37 and 38: 4HC-Purged Autologous Stem Cell Tra
Page 39 and 40: 1.0-1 + 0.2 Miller et al. 5 Event F
Page 41 and 42: Miller et al. Adjusted probability
Page 43 and 44: Who Benefits From Autograft in AML
Page 45 and 46: Burnett 11 which to set the transpl
Page 47 and 48: Table 1. Outcome after relapse in M
Page 49 and 50: Immunotherapy in AML: No Positive E
Page 51 and 52: Simonsson et al. inhibit IL-2 induc
Page 53 and 54: Autologous Bone Marrow Transplantat
Page 55 and 56: Ball et al. 21 CD15) and AML-2-23 (
Page 57 and 58: Ball et al. 23 The ex vivo treatmen
Page 59 and 60: Ball et al. 25 Table 2. Factors inv
Page 61 and 62: Ball et al. Overall Survival for Pa
Page 63 and 64: Ball et al. Overall Survival for Pa
Page 65 and 66: Ball et al. 31 Overall Survival for
Page 67 and 68: Ball et al. Table 4. Actuarial over
Page 69 and 70: Ball et al. myeloid leukemia. The G
Page 71 and 72:
Ball et al. 1993. 38. Mehta J, Powl
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Can Autologous Stem Cell Transplant
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De Witte et al. 41 novo AML. Auer r
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De Witte et al. hematopoietic engra
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De Witte et al. 23. Fenaux P, Laï
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Stein et al. and fever. No patient
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Stein et al. after doses 1, 3, and
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Stein et al. early after the transp
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autologous stem-cell rescue. / Clin
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Bone Marrow Transplantation for Acu
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Table 2. Autologous BMT in ALL in f
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Rowe 61 or adult patients with acut
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Hoelzer and Gôkbuget minitransplan
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Hoelzer and Gdkbuget 65 blood, earl
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Table 3. Risk factors for the defin
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Hoelzer and Gôkbuget treatment opt
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Hoeker and Gökbuget tical sibling
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Sierra et al. INTRODUCTION Two-thir
Page 109 and 110:
Sierra et al. Table 2. Adverse char
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1,0 0,0 J Sierra et al. 0 20 40 60
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Sierra et al. Months Figure 4 < 30,
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Sierra et al. No adverse factors (n
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1994. Sierra et al. 83 10. Canals C
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Martin, Atta, and Hoelzer 85 adult
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Martin, Atta, and Hoelzer 87 Single
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100. Martin, Atta, and Hoelzer 89 P
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Martin, Atta, and Hoelzer 91 chromo
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Autologous vs. Unrelated Allogeneic
Page 129 and 130:
Boyer and Yeager 95 outcomes after
Page 131 and 132:
Boyer and Y eager 97 Table 2. Hypot
Page 133 and 134:
Boyer and Y eager SUMMARY Most of t
Page 135:
CHAPTER 3 CML
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Autograft Followed by Allograft Wit
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106 Chapter 3: CML (one low-grade a
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108 Chapter 3: CML DISCUSSION Myelo
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110 Chapter 3: CML Philadelphia-neg
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The Case for Manipulation of CML Au
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Toward a Cure by Drug Treatment? Th
Page 150 and 151:
116 Chapter 3 :CML Table 1. Prolong
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118 Chapter 3: CML Table 3. German
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120 Chapter 3: CML Table 5. Normal
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122 Chapter 3: CML Table 8. Surviva
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124 Chapter 3: CML 88:3118-3122, 19
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126 Chapter 3: CML RK, Klingemann H
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The Tyrphostin AG957 Inhibits the I
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130 Chapter 3: CML mobilization. Al
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132 Chapter 3: CML A B 100 n 0 1 5
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134 Chapter 3: CML The in vitro sel
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136 Chapter 3: CML detecting leukem
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Progressive Hodglcin's Lymphoma Fol
Page 175 and 176:
Reece et al. survival is observed i
Page 177 and 178:
0.2 -I 0.0 0 Reece et al. 143 ii i
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Reece et al. Table 3. Causes of non
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Reece et al. carmustine, etoposide
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CD34 + Selection of Hematopoietic B
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Lazarus et al. 151 significantly de
Page 187 and 188:
Lazarus et al. 153 (Sigma, St Louis
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Lazarus et al. 155 Table 2. Effect
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Lazarus et al. 157 difference. Furt
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Lazarus et al. 159 cells after myel
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The European CUP/UP Trial: A Prelim
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Table 1. Patient characteristics at
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Schouten et al. licular non-Hodgkin
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Sweetenham et al. vs. autologous pe
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Table 1. Patient characteristics, g
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Table 2. Patient characteristics, g
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Table 3. Sites of relapse, group A
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Table 4. Patterns of relapse, group
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A 100 80 %OS 60 40 20 B 100 %OS | S
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Sweetenham et al. new sites, and fi
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Sweetenham et al. Treatment options
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Molecular Remission: A Worthwhile A
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Early or Late Autotransplant in Hig
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Schenkein et al. 187 PATIENTS AND M
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Schenkein et al. 189 Toxicity Toxic
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Schenkein et al. 191 16. Glick JH,
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Santini et al. 193 to evaluate the
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Table 1. Continued Santini et al. 1
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Santini et al. 197 cytosine arabino
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1 0 0 1 90- 80- 70- (0 u. 60' o so-
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Hodgkin's lymphoma. N EnglJ Med 333
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CHAPTER 5 MYELOMA
Page 240 and 241:
206 Chapter 5: Myeloma independent
Page 242 and 243:
208 Chapter 5: Myeloma disease (MRD
Page 244 and 245:
210 Chapter 5: Myeloma Scandinavia,
Page 246 and 247:
212 Chapter 5: Myeloma (0 n o B co
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214 Chapter 5: Myeloma B cq d ? o c
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216 Chapter 5: Myeloma patients wit
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218 Chapter 5: Myeloma PBSC transpl
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220 Chapter 5: Myeloma 25. Seiden M
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Autologous Transplantation in Multi
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224 Chapter 5: Myeloma 0 52 44 U §
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226 Chapter 5: Myeloma BM ^ (CD34±
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228 Chapter 5: Myeloma IFM 94 : OS
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230 Chapter 5: Myeloma two groups a
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232 Chapter 5: Myeloma increase bot
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234 Chapter 5: Myeloma REFERENCES 1
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236 Chapter 5: Myeloma Intensified
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238 Chapter 5: Myeloma of CD34 + ce
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Chapter 5: Myeloma Table 2. Descrip
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242 Chapter 5: Myeloma o 8H 0 2 4 6
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244 Chapter 5: Myeloma ated with sh
Page 281 and 282:
The Presence of Micrometastases in
Page 283 and 284:
Kvalheim et al. 249 Table 1. Immuno
Page 285 and 286:
Kvalheim et al. 251 Figure 1. Sixty
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Kvalheim et al. 253 DISCUSSION In t
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Kvalheim et al. 255 Bastert G: Micr
Page 291 and 292:
Hood et al. 257 In an effort to inc
Page 293 and 294:
#CD34 + cells in blood = Hood et al
Page 295 and 296:
Hood et al. 261 Table 3. Frequency
Page 297 and 298:
Hood et al. 263 REFERENCES 1. Rill
Page 299 and 300:
The Clinical Significance of Breast
Page 301 and 302:
Moss et al. tests, and bilateral po
Page 303 and 304:
Moss et al. 269 0 15 70 143 200 400
Page 305 and 306:
Moss et al. 271 0 3 6 12 18 24 30 3
Page 307 and 308:
Moss et al. 273 8. Passos-Coelho J,
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Autotransplantation for Men With Br
Page 311 and 312:
McCarthy et al. 277 radiation, two
Page 313 and 314:
High Dose Sequential Chemotherapy W
Page 315 and 316:
Viens et al. 281 3 g/m 2 and doxoru
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Table 1. Tumor characteristics Exte
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Table 4. Response Viens et al. 285
Page 321 and 322:
Viens et al. 287 Table 5. Pathologi
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Viens et al. 289 apy for inoperable
Page 325 and 326:
Gliick et al. 291 INTRODUCTION The
Page 327 and 328:
Gluck et al. 293 RESULTS Patient de
Page 329 and 330:
Glück et al. 295 Table 3. Response
Page 331 and 332:
Gluck et al. 297 Overall Survival O
Page 333 and 334:
Gluck et al. 299 Sudbury patients w
Page 335 and 336:
Gluck et al. 301 anthracycline or t
Page 337 and 338:
Repetitive High-Dose Therapy With P
Page 339 and 340:
Prince et al. paramagnetic separati
Page 341 and 342:
Prince et al. Table 1. High-dose re
Page 343 and 344:
Table 2. Patient characteristics (n
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Table 4. Hematopoietic recovery fol
Page 347 and 348:
1.0- M C .S 0.8- a c *fe o o> 0.6-
Page 349 and 350:
M 1.0 I 0.8H s? VI o.6H S 0.2 0.0 P
Page 351 and 352:
a Prince et al. days to platelets >
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Table 5. Results of Isolex 300i CD3
Page 355 and 356:
Prince et al. 321 Figure 5, continu
Page 357 and 358:
Prince et al. 323 months after tran
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Prince et al. 325 excessive to be u
Page 361 and 362:
Prince et al. 327 eight patients ha
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Prince et al. 329 marrow transplant
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Prince et al. intensive chemotherap
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-Q CO .Q O 1.0 0.9 0.8 0.7 0.6 0.5
Page 369 and 370:
.Q CD .Q O 1.0 0.9 0.8 0.7 0.6 0.5
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oba Q. 1.0 0.9 Dicke et al. Stage I
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Vahdat with peripheral blood progen
Page 375 and 376:
Evaluation of Prognostic Factors fo
Page 377 and 378:
Fields et al. 343 PATIENTS AND METH
Page 379 and 380:
Table 1. Chemotherapy regimens. Fie
Page 381 and 382:
Fields et al. Stage II; 4-9 Pos LN
Page 383 and 384:
U U Fields et al.
Page 385 and 386:
Fields et al. 351 between 1 and 2 y
Page 387 and 388:
European Trends and the EBMT Databa
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25% % 22% / 17% \ Rosti et al. 355
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Rosti et al. 357 The new Italian St
Page 393 and 394:
Page 395 and 396:
Rosti et al. 6. Haas R, Schmid H, H
Page 397 and 398:
Bewick et al. 363 INTRODUCTION The
Page 399 and 400:
Bewick et al. 365 Blood samples obt
Page 401 and 402:
Bewick et al. 367 HDCT with ABSC su
Page 403 and 404:
Bewick et al. Progression Free Surv
Page 405 and 406:
Bewick et al. pression in MBC, i.e.
Page 407 and 408:
Bewick et al. 14. Kandl HL, Seymour
Page 409:
CHAPTER 7 OTHER SOLID TUMORS
Page 412 and 413:
378 Chapter 7: Solid Tumors INTRODU
Page 414 and 415:
380 Chapter 7: Solid Tumors Prepara
Page 416 and 417:
382 Chapter 7: Solid Tumors Surviva
Page 418 and 419:
384 Chapter 7: Solid Tumors months
Page 420 and 421:
386 Chapter 7: Solid Tumors have be
Page 422 and 423:
High-Dose Chemotherapy in the Manag
Page 424 and 425:
390 Chapter 7: Solid Tumors followe
Page 426 and 427:
392 Chapter 7: Solid Tumors Table 1
Page 428 and 429:
394 Chapter 7: Solid Tumors (mucosi
Page 430 and 431:
Three-Fold Intensification by Seque
Page 432 and 433:
Page 434 and 435:
Page 436 and 437:
High-Dose Therapy for Small Cell Lu
Page 438 and 439:
404 Chapter 7: Solid Tumors chemoth
Page 440 and 441:
406 Chapter 7: Solid Tumors SCLC ha
Page 442 and 443:
408 Chapter 7: Solid Tumors relapse
Page 444 and 445:
410 Chapter 7: Solid Tumors 69:585-
Page 446 and 447:
412 Chapter 7: Solid Tumors ogous b
Page 448 and 449:
414 Chapter 7: Solid Tumors 64. Bru
Page 450 and 451:
416 Chapter 7: Solid Tumors Prignot
Page 452 and 453:
418 Chapter 7: Solid Tumors CO > CO
Page 454 and 455:
420 Chapter 7: Solid Tumors TANDEM
Page 456 and 457:
Multiple Courses of Cyclophosphamid
Page 458 and 459:
424 Chapter 7: Solid Tumors and the
Page 460 and 461:
426 Chapter 7: Solid Tumors Thiotep
Page 462 and 463:
Page 464 and 465:
430 Chapter 7: Solid Tumors E 100 0
Page 466 and 467:
432 Chapter 7: Solid Tumors course
Page 468 and 469:
434 Chapter 7: Solid Tumors boplati
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436 Chapter 7: Solid Tumors INTRODU
Page 472 and 473:
438 - Chapter 7: Solid Tumors Table
Page 474 and 475:
440 Chapter 7: Solid Tumors seeded
Page 476 and 477:
442 Chapter 7: Solid Tumors DISCUSS
Page 478 and 479:
444 Chapter 7: Solid Tumors 10. Di
Page 480 and 481:
446 Chapter 7: Solid Tumors plasma
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Autologous Stem Cell Transplantatio
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Keystone 451 hypertension, anemia,
Page 487 and 488:
Fassas et al. 453 INTRODUCTION Mult
Page 489 and 490:
Fassas et al. Table 2. Stem cell mo
Page 491 and 492:
Table 3. Toxicity after stem cell i
Page 493 and 494:
Fassas et al. Table 5. Trial 1: cha
Page 495 and 496:
Fassas et al. MS PROGRESSION FREE S
Page 497 and 498:
Fassas et al. ic or autologous bone
Page 499 and 500:
1 2 1 6 EAE. Burt et al. 465 Becaus
Page 501 and 502:
Burt et al. Since cyclophosphamide
Page 503 and 504:
Burt et al. 469 toxicity study, we
Page 505 and 506:
Burt et dl. All 23. Mor F, Cohen IR
Page 507 and 508:
Hasler, Gratwohl, and Tyndall an ev
Page 509 and 510:
Hasler, Gratwohl, and Tyndall 475 B
Page 511 and 512:
Kuis, Wulffraat, and Sanders 477 st
Page 513 and 514:
Kuis, Wulffraat, and Sanders neousl
Page 515:
CHAPTER 9 LONG-TERM EFFECTS
Page 518 and 519:
484 Chapter 9: Long-Term Effects po
Page 520 and 521:
486 Chapter 9: Long-Term Effects Ta
Page 522 and 523:
488 Chapter 9: Long-Term Effects ml
Page 524 and 525:
490 Chapter 9: Long-Term Effects 4.
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492 Chapter 9: Long-Term Effects us
Page 528 and 529:
494 Chapter 9: Long-Term Effects AB
Page 530 and 531:
Page 532 and 533:
498 Chapter 9: Long-Term Effects En
Page 534 and 535:
500 Chapter 9: Long-Term Effects Rl
Page 536 and 537:
502 Chapter 9: Long-Term Effects RE
Page 538 and 539:
504 Chapter 9: Long-Term Effects A,
Page 540 and 541:
Long-Term Follow-Up of Autologous T
Page 542 and 543:
Page 545:
CHAPTER 10 GRAFT MANIPULATION
Page 548 and 549:
514 Chapter 10: Graft Manipulation
Page 550 and 551:
Page 552 and 553:
Page 554 and 555:
Page 556 and 557:
Page 558 and 559:
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Page 604 and 605:
Page 606 and 607:
Stem Cell Reinfusion Over Two Conse
Page 608 and 609:
Page 610 and 611:
Page 612 and 613:
Page 614 and 615:
Final Report of the First Prospecti
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Page 628 and 629:
Page 630 and 631:
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Page 635 and 636:
Canine Hematopoietic Stem Allograft
Page 637 and 638:
Sandmaier et al. 603 The resultant
Page 639 and 640:
Sandmaier et al. 605 synthesis path
Page 641 and 642:
Sandmaier et al. 607 interactions o
Page 643 and 644:
Sandmaier et al. 1991. 2. Burchenal
Page 645 and 646:
87:3508-3513,1996. Sandmaier et al.
Page 647 and 648:
Giralt, Khouri, and Champlin Table
Page 649 and 650:
Giralt, Khouri, and Champlin seven
Page 651 and 652:
1.0 3 0.2 Giralt, Khouri, and Champ
Page 653:
CHAPTER 12 GENE THERAPY
Page 656 and 657:
622 Chapter 12: Gene Therapy INTROD
Page 658 and 659:
624 Chapter 12: Gene Therapy RESULT
Page 660 and 661:
626 Chapter 12: Gene Therapy envisi
Page 662 and 663:
628 Chapter 12: Gene Therapy cer in
Page 664 and 665:
A Vaccine of Melanoma Peptide Loade
Page 667 and 668:
B43(anti-CD 19)-Gen i stein Immunot
Page 669 and 670:
Targeting Immunotherapy for the Tre
Page 671 and 672:
McGuinness andArceci 637 modified m
Page 673 and 674:
McGuinness andArceci 639 leukemic c
Page 675 and 676:
McGuinness and Arced 641 in G418. T
Page 677 and 678:
McGuinness andArceci 643 Figure 2
Page 679 and 680:
mRNA for hB7-1 (1491 bp) mRNA for C
Page 681 and 682:
McGuinness and Arced CD80PE C080PE
Page 683 and 684:
McGuinness andArceci 649 8. Robert
Page 685 and 686:
McGuinness andArceci immune respons
Page 687 and 688:
McGuinness andArceci 75. Jubinsky F
Page 689 and 690:
Slavin et al. 655 up suggests, as p
Page 691 and 692:
Slavin et al. 657 was a phase lib c
Page 693 and 694:
Slavin et al. presented, appears to
Page 695 and 696:
Antitumor Immunotherapy in Autologo
Page 697 and 698:
Klingemann et al. 663 Table 3. Meth
Page 699:
CHAPTER 14 RADIOIMMUNOTHERAPY
Page 702 and 703:
668 Chapter 14: Radioimmunotherapy
Page 704 and 705:
Page 706 and 707:
Page 708 and 709:
Page 710 and 711:
Page 712 and 713:
Page 714 and 715:
Selection of Radioisotopes, Chelate
Page 716 and 717:
Page 718 and 719:
Page 720 and 721:
Page 722 and 723:
Page 724 and 725:
Page 726 and 727:
Radioimmunotherapy of Common Epithe
Page 729:
CHAPTER 15 NEW AVENUES
Page 732 and 733:
698 Chapter 15: New Avenues Table 1
Page 734 and 735:
700 Chapter 15: New Avenues An alte
Page 736 and 737:
702 Chapter 15: New Avenues who can
Page 738 and 739:
704 Chapter 15: New Avenues myeloid
Page 740 and 741:
706 Chapter 15: New Avenues 48. Gir
Page 742 and 743:
Emerging Viral Infections in Blood
Page 744 and 745:
710 Chapter 15: New Avenues influen
Page 746 and 747:
712 Chapter 15: New Avenues Among a
Page 748 and 749:
714 Chapter 15: New Avenues physica
Page 750 and 751:
716 Chapter 15: New Avenues respira
Page 752 and 753:
Minimal Therapy Models of Transplan
Page 755:
CHAPTER 16 SUMMARIES
Page 758 and 759:
724 Chapter 16: Summaries although
Page 760 and 761:
726 Chapter 16: Summaries use of po
Page 762 and 763:
728 Chapter 16: Summaries Table 1.
Page 764 and 765:
Page 766 and 767:
Page 768 and 769:
Page 770 and 771:
736 Chapter 16: Summaries IL-15. Th
Page 772 and 773:
738 Chapter 16: Summaries Patterns
Page 774 and 775:
740 List of Participants Thomas L.
Page 776 and 777:
742 List of Participants Sergio A.
Page 778 and 779:
744 List of Participants Hans Marti
Page 780 and 781:
746 List of Participants David P. S
Page 782 and 783:
748 List of Participants AUTHOR IND
Page 784 and 785:
750 Author Index Hurd, D.D. 483 Kui
Page 786 and 787:
752 Author Index Stiff, Patrick J.
Page 788 and 789:
754 Key Word Index Hematologic mali
Page 792:
ISBN 1-891524-04-6
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