autologous blood and marrow transplantation - Blog Science ...

154 Chapter 4: Lymphoma
Missing data were not estimated or carried forward in any statistical analyses.
The analysis of the time to platelet engraftment used a one-sided test. For the
additional end points, the between-group comparisons used two-tailed test
procedures. A significance level of 0.05 (a=0.05) was used for all analyses. The
null hypothesis of interest for all analyses was that there was no difference between
the study groups. The study groups were compared with respect to age and the
processing data using two-sample t tests. The Cox proportional hazards regression
model was used to analyze the engraftment data. Fisher's exact test was used to
analyze sex and performance status.
Analyses based on the x 2
test for homogeneity of proportions were performed
only if the counts in all cells of the frequency table represented at least 5% of the
patients included in the analysis. If any of the counts were lower than this value,
Fisher's exact test was used.
RESULTS
Patient characteristics
The clinical characteristics of the study patients who were included in the
analyses are summarized in Table 1. There were no significant differences between
the study groups in terms of sex, age, or ECOG performance status.
Characterization of peripheral blood CD34 +
cells and
results of positive selection
Seventy-four leukapheresis products (collected from 30 patients) processed the
same day as the leukapheresis procedure were compared with 62 leukapheresis
Table 1. Patient characteristics
Immediate processing (n=30) Overnight storage (n=23) P value
Sex 1.000
Male 15 (50%) 12(52%)
Female 15 (50%) 11(48%)
Age (years) 0.680
Median 50 44
Range 22-65 18-66*
ECOG rating 1.00
0-1 (n=28) 24 (86%)t 19(83%)
2 4 (14%) 4(17%)
*One patient was age 65 years at study registration, hut was age 66 years at time of transplant.
fn=28; two patients were evaluated using Karnofsky performance test and had 90% ratings.