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748 List of Participants AUTHOR INDEX Abonour, Rafat 388 Benvenuto, Federica 104 Champlin, Richard 612, 697 Abruzzese, E.A. 483 Berger, U. 114 Chang, J. 139 Ackerstein, Aliza 654 Berkahn, Leanne 661 Chauhan, Dharminder 207 Adams, John W. 332 Bewick, M. 362 Cheng, Dong 464 Alyea, Edwin 207 BGMT Group 38 Cheson, B. 205 Amadori, S. 483 Bieniaszewska, B. 114 Chisesi, Teodoro 192 Anagnostopoulos, Bierman, P. 184 Cilloni, Daniela 128 Achilles 452 Bishop, M. 184 Cirenza, Emanuel 275 Anaissie, E. 205 Björkstrand, B. 231 Cocconi, Giorgio 435 Anderson, Kenneth 207 Blaise, D. 38 Congiu, Angela Marina 192 Anker, Gunn 247 Blakey, David 303 Conlon, M. 362 Antman, Karen S. 275 Blumenschein, Contant, Charles F. 513 Aposolidis, J. 183 George R. 256, 332 Contu, Antonio 192 Apperley, J. 231 Bociek, Gregory R. 290 Cooper, Apperley, J.F. 103,111 Borchardt, P.E. 680 Brenda W. 149, 265 Apperley, Jane 39 Bosquee, L. 396 Copelan, Edward 265 Arber, Daniel 46 Bosse, Roland 551 Cornetta, Kenneth 388 Arceci, Robert J. 635 Boyer, Michael W. 93 Corsetti, Maria T. 104 Armitage, J. 184 Boyle, Terry 185 Craddock, C. 103 Armitage, James O. 275 Brack, N. 114 Cremer, F.W. 235 Arneson, Mark A. 332 Brenner, Malcolm K. 513 Cromer, J. 205 Arnold, Wolfgang 529 Brune, Mats 15 Cross, N.C.P. 103 Atta, Johannes 84 Brunet, Salut 72 Crowley, J. 205 Attal, Michel 222 Buchdunger, E. 113 Crump, Michael 275, 290 Ayers, D. 205 Buckner, C. Dean 265 Cruz, J.M. 483 Baars, Joke W. 422 Burnett, A.K. 9 CUP Trial Cooperative Bacigalupo, Andrea 104 Burt, Richard K. 464 Group 161 Ball, Edward D. 19 Busemann, C. 114 Dagis, Andrew 46 Ballester, Oscar F. 580 Canals, Carmen 72 Damasio, Eugenio 192 Bargetzi, M. 114 Carella, A. 114 Dardenne, Murielle 39 Barlogie, B. 205 Carella, A.M. 111 Dazzi, F. 103 Barnett, Michael 112,140 Carella, Angelo M. 104 De Souza, Carmino 192 Barrett, John 723 Carlo-Stella, De Stefano, Francesco 104 Barsoukov, Alexander 601 Carmelo 128,435 De Witte, Theo M. 39 Basten, G. 274 Carlson, K. 231 Deeg, H. Joachim 507 Bauduer, F. 38 Carreras, Enríe 72 Dejana, Anna 104 Bayer, Robert A. 377 Casarino, Lucia 104 Delozier, T. 279 Begent, R.H.J. 692 Cassileth, Peter 185 Desikan, R. 205 Beijnen, Jos H. 422 Cavo, M. 231 Dhodapkar, D. 205 Ben-Yosef, Rami 654 Celesti, Lidia 104 Di Blasio, Beatrice 435 Benner, A. 235 Centurioni, Riccardo 192 Dicke, Benoit, Brian 719 Chadderton, T. 362 Karel A. 256, 332, 572 748
DiStefano, Alfred 332 Dodero, Anna 435 Donnell, Peggy J. 256 Dörken, Bernd 529 Doroshower, James 275 Druker, B.J. 113 Dube, I.D. 629 Eaves, Allen 112 Eaves, Connie 112 Eggert, J. 114 Eguchi, Haruhiko 417 Ehrbrecht, E. 235 Eimermacher, H. 114 Einhorn, Lawrence 388 Elfenbein, Gerald J. 341,580,727 Elias, Anthony 402 Elser, C. 114 Emmerich, B. 114 Endrizzi, Luigi 192 Engstrom, Caron 719 Epstein, J. 205 Erikstein, Bj0rn 247 European Group for Blood and Marrow Transplantation 231 Fabbro, M. 279 Faberes, C. 38 Falge, C. 114 Fassas, A. 205 Fassas, Athanasios 452 Fauser, A.A. 114 Ferrant, A. 231 Ferrante, Patrizia 353 Fichtner, Iduna 551 Fields, Karen K. 341, 580 Figari, Osvaldo 104 Firstenberg, Barry A. 332 Fischer, T. 114 Fisher, Darreil R. 681 Flowers, Mary 507 Forman, Stephen J. 46 Forrest, Donna 140 Fouillard,L. 231 Author Index 749 Franciosi, Vittorio 435 Francis, K. 717 Freeman, Andrea 207 Freytes, Cesar O. 275 Fulbright, Lorene K. 256 Fulbright, Lorene 575 Funk, L. 274 Gahrton, G. 231 Gale, Robert Peter 275 Garau, Daniela 128,435 Garcia, Joan 72 Gates, Priscilla 303 Gazit, Aviv 128 Gee, Adrian P. 541 Geissler, K. 114 German CML Study Group 114 Gerson, Stanton L. 149 Gilen, Ester 247 Giralt, Sergio 612, 697 Glück, S. 362 Glück, Stefan 290 Gmür, J. 114 Goan, Silvia-Renate 551 Gökbuget, Nicola 62 Goldman, J.M. 103, 111, 114 Goldschmidt, H. 235, 274 Goldstein, L.C. 521 Goldstein, Steven C. 341, 580 Goldstone, Anthony H. 166 Gong, Jianling 207 Gordon, Leo I. 693 Gorin, N.C. 491 Gratecos, N. 231 Gratwohl, A. 114, 231 Gratwohl, Alois 39, 472 Grießhammer, M. 114 Grimes,Barry 621 Grimminger, W. 114 Groner, Bernd 551 Guarnaccia, Clara 192 Guilhot, F. 231 Gupta, R. 183 Gupta, R.K. 139 Haas, R. 235, 274 Haas, Rainer 561 Hahn, U. 274 Hamdan, O. 396 Hanks, Sylvia 332, 572 Harousseau, Jean-Luc 222 Hasford, J. 114 Hasler, Paul 472 Hegenbart, U. 235 Hehlmann, R. 114 Heimpel.H. 114 Hellstrand, Kristoffer 15 Hempel, D. 114 Henschler, Reinhard 551 Herbst, Birgit 630 Hermans, Jo 39 Hervik, Iris 247 Herzig, Roger H. 265 Heslop, Helen E. 513 Hiemenz, John W. 580 Hildebrandt, Martin 529 Hinrichs, H.-F. 114 Ho, A.D. 235, 274, 717 Ho, Anthony D. 561 Hochhaus, A. 114 Hoelzer, Dieter 62, 84 Hoffmann, T. 114 Hohaus, S. 274 Hohaus, Stefan 561 Holtkamp, Marjo M.J. 422 Hood, Deborah L. 256, 332, 572 Horowitz, M.M. 275 Horowitz, Mary M. 1 Horwitz, Edwin M. 513 Hossfeld, D.K. 114 Howard, Dianna S. 621 Huang, S. 717 Huber, C. 114 Huitema, Alwin D.R. 422 Hulspas, Ruud 719 Humblet, Y. 396
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AUTOLOGOUS BLOOD AND MARROW TRANSPL
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AUTOLOGOUS BLOOD AND MARROW TRANSPL
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ACKNOWLEDGMENTS We wish to thank Wi
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THE VAN BEKKUM STEM CELL AWARD Prof
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xii Table of Contents CHAPTER 2: AL
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xiv Table of Contents Late Non-Rela
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xvi Table of Contents Pretreatment
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xviii Table of Contents CHAPTER 7:
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XX Table of Contents Long-Term Obse
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xxii Table of Contents CHAPTER 13:
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0-9 LIST OF ABBREVIATIONS 2CDA 2-ch
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List of Abbreviations xxvii EFS eve
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List of Abbreviations MOPP mechlore
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VOD veno-occlusive disease VPC viru
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4HC-Purged Autologous Stem Cell Tra
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1.0-1 + 0.2 Miller et al. 5 Event F
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Miller et al. Adjusted probability
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Who Benefits From Autograft in AML
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Burnett 11 which to set the transpl
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Table 1. Outcome after relapse in M
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Immunotherapy in AML: No Positive E
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Simonsson et al. inhibit IL-2 induc
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Autologous Bone Marrow Transplantat
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Ball et al. 21 CD15) and AML-2-23 (
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Ball et al. 23 The ex vivo treatmen
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Ball et al. 25 Table 2. Factors inv
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Ball et al. Overall Survival for Pa
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Ball et al. Overall Survival for Pa
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Ball et al. 31 Overall Survival for
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Ball et al. Table 4. Actuarial over
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Ball et al. myeloid leukemia. The G
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Ball et al. 1993. 38. Mehta J, Powl
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Can Autologous Stem Cell Transplant
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De Witte et al. 41 novo AML. Auer r
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De Witte et al. hematopoietic engra
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De Witte et al. 23. Fenaux P, Laï
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Stein et al. and fever. No patient
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Stein et al. after doses 1, 3, and
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Stein et al. early after the transp
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autologous stem-cell rescue. / Clin
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Bone Marrow Transplantation for Acu
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Table 2. Autologous BMT in ALL in f
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Rowe 61 or adult patients with acut
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Hoelzer and Gôkbuget minitransplan
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Hoelzer and Gdkbuget 65 blood, earl
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Table 3. Risk factors for the defin
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Hoelzer and Gôkbuget treatment opt
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Hoeker and Gökbuget tical sibling
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Sierra et al. INTRODUCTION Two-thir
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Sierra et al. Table 2. Adverse char
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1,0 0,0 J Sierra et al. 0 20 40 60
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Sierra et al. Months Figure 4 < 30,
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Sierra et al. No adverse factors (n
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1994. Sierra et al. 83 10. Canals C
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Martin, Atta, and Hoelzer 85 adult
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Martin, Atta, and Hoelzer 87 Single
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100. Martin, Atta, and Hoelzer 89 P
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Martin, Atta, and Hoelzer 91 chromo
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Autologous vs. Unrelated Allogeneic
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Boyer and Yeager 95 outcomes after
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Boyer and Y eager 97 Table 2. Hypot
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Boyer and Y eager SUMMARY Most of t
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CHAPTER 3 CML
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Autograft Followed by Allograft Wit
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106 Chapter 3: CML (one low-grade a
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108 Chapter 3: CML DISCUSSION Myelo
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110 Chapter 3: CML Philadelphia-neg
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The Case for Manipulation of CML Au
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Toward a Cure by Drug Treatment? Th
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116 Chapter 3 :CML Table 1. Prolong
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118 Chapter 3: CML Table 3. German
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120 Chapter 3: CML Table 5. Normal
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122 Chapter 3: CML Table 8. Surviva
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124 Chapter 3: CML 88:3118-3122, 19
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126 Chapter 3: CML RK, Klingemann H
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The Tyrphostin AG957 Inhibits the I
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130 Chapter 3: CML mobilization. Al
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132 Chapter 3: CML A B 100 n 0 1 5
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134 Chapter 3: CML The in vitro sel
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136 Chapter 3: CML detecting leukem
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Progressive Hodglcin's Lymphoma Fol
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Reece et al. survival is observed i
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0.2 -I 0.0 0 Reece et al. 143 ii i
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Reece et al. Table 3. Causes of non
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Reece et al. carmustine, etoposide
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CD34 + Selection of Hematopoietic B
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Lazarus et al. 151 significantly de
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Lazarus et al. 153 (Sigma, St Louis
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Lazarus et al. 155 Table 2. Effect
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Lazarus et al. 157 difference. Furt
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Lazarus et al. 159 cells after myel
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The European CUP/UP Trial: A Prelim
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Table 1. Patient characteristics at
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Schouten et al. licular non-Hodgkin
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Sweetenham et al. vs. autologous pe
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Table 1. Patient characteristics, g
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Table 2. Patient characteristics, g
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Table 3. Sites of relapse, group A
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Table 4. Patterns of relapse, group
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A 100 80 %OS 60 40 20 B 100 %OS | S
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Sweetenham et al. new sites, and fi
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Sweetenham et al. Treatment options
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Molecular Remission: A Worthwhile A
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Early or Late Autotransplant in Hig
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Schenkein et al. 187 PATIENTS AND M
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Schenkein et al. 189 Toxicity Toxic
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Schenkein et al. 191 16. Glick JH,
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Santini et al. 193 to evaluate the
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Table 1. Continued Santini et al. 1
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Santini et al. 197 cytosine arabino
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1 0 0 1 90- 80- 70- (0 u. 60' o so-
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Hodgkin's lymphoma. N EnglJ Med 333
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CHAPTER 5 MYELOMA
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206 Chapter 5: Myeloma independent
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208 Chapter 5: Myeloma disease (MRD
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210 Chapter 5: Myeloma Scandinavia,
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212 Chapter 5: Myeloma (0 n o B co
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214 Chapter 5: Myeloma B cq d ? o c
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216 Chapter 5: Myeloma patients wit
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218 Chapter 5: Myeloma PBSC transpl
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220 Chapter 5: Myeloma 25. Seiden M
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Autologous Transplantation in Multi
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224 Chapter 5: Myeloma 0 52 44 U §
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226 Chapter 5: Myeloma BM ^ (CD34±
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228 Chapter 5: Myeloma IFM 94 : OS
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230 Chapter 5: Myeloma two groups a
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232 Chapter 5: Myeloma increase bot
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234 Chapter 5: Myeloma REFERENCES 1
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236 Chapter 5: Myeloma Intensified
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238 Chapter 5: Myeloma of CD34 + ce
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Chapter 5: Myeloma Table 2. Descrip
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242 Chapter 5: Myeloma o 8H 0 2 4 6
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244 Chapter 5: Myeloma ated with sh
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The Presence of Micrometastases in
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Kvalheim et al. 249 Table 1. Immuno
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Kvalheim et al. 251 Figure 1. Sixty
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Kvalheim et al. 253 DISCUSSION In t
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Kvalheim et al. 255 Bastert G: Micr
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Hood et al. 257 In an effort to inc
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#CD34 + cells in blood = Hood et al
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Hood et al. 261 Table 3. Frequency
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Hood et al. 263 REFERENCES 1. Rill
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The Clinical Significance of Breast
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Moss et al. tests, and bilateral po
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Moss et al. 269 0 15 70 143 200 400
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Moss et al. 271 0 3 6 12 18 24 30 3
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Moss et al. 273 8. Passos-Coelho J,
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Autotransplantation for Men With Br
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McCarthy et al. 277 radiation, two
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High Dose Sequential Chemotherapy W
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Viens et al. 281 3 g/m 2 and doxoru
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Table 1. Tumor characteristics Exte
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Table 4. Response Viens et al. 285
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Viens et al. 287 Table 5. Pathologi
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Viens et al. 289 apy for inoperable
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Gliick et al. 291 INTRODUCTION The
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Gluck et al. 293 RESULTS Patient de
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Glück et al. 295 Table 3. Response
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Gluck et al. 297 Overall Survival O
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Gluck et al. 299 Sudbury patients w
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Gluck et al. 301 anthracycline or t
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Repetitive High-Dose Therapy With P
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Prince et al. paramagnetic separati
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Prince et al. Table 1. High-dose re
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Table 2. Patient characteristics (n
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Table 4. Hematopoietic recovery fol
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1.0- M C .S 0.8- a c *fe o o> 0.6-
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M 1.0 I 0.8H s? VI o.6H S 0.2 0.0 P
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a Prince et al. days to platelets >
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Table 5. Results of Isolex 300i CD3
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Prince et al. 321 Figure 5, continu
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Prince et al. 323 months after tran
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Prince et al. 325 excessive to be u
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Prince et al. 327 eight patients ha
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Prince et al. 329 marrow transplant
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Prince et al. intensive chemotherap
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-Q CO .Q O 1.0 0.9 0.8 0.7 0.6 0.5
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.Q CD .Q O 1.0 0.9 0.8 0.7 0.6 0.5
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oba Q. 1.0 0.9 Dicke et al. Stage I
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Vahdat with peripheral blood progen
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Evaluation of Prognostic Factors fo
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Fields et al. 343 PATIENTS AND METH
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Table 1. Chemotherapy regimens. Fie
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Fields et al. Stage II; 4-9 Pos LN
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U U Fields et al.
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Fields et al. 351 between 1 and 2 y
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European Trends and the EBMT Databa
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25% % 22% / 17% \ Rosti et al. 355
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Rosti et al. 357 The new Italian St
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Rosti et al. 6. Haas R, Schmid H, H
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Bewick et al. 363 INTRODUCTION The
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Bewick et al. 365 Blood samples obt
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Bewick et al. 367 HDCT with ABSC su
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Bewick et al. Progression Free Surv
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Bewick et al. pression in MBC, i.e.
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Bewick et al. 14. Kandl HL, Seymour
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CHAPTER 7 OTHER SOLID TUMORS
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378 Chapter 7: Solid Tumors INTRODU
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380 Chapter 7: Solid Tumors Prepara
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382 Chapter 7: Solid Tumors Surviva
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384 Chapter 7: Solid Tumors months
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386 Chapter 7: Solid Tumors have be
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High-Dose Chemotherapy in the Manag
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390 Chapter 7: Solid Tumors followe
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392 Chapter 7: Solid Tumors Table 1
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394 Chapter 7: Solid Tumors (mucosi
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Three-Fold Intensification by Seque
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High-Dose Therapy for Small Cell Lu
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404 Chapter 7: Solid Tumors chemoth
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406 Chapter 7: Solid Tumors SCLC ha
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408 Chapter 7: Solid Tumors relapse
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410 Chapter 7: Solid Tumors 69:585-
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412 Chapter 7: Solid Tumors ogous b
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414 Chapter 7: Solid Tumors 64. Bru
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416 Chapter 7: Solid Tumors Prignot
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418 Chapter 7: Solid Tumors CO > CO
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420 Chapter 7: Solid Tumors TANDEM
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Multiple Courses of Cyclophosphamid
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424 Chapter 7: Solid Tumors and the
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426 Chapter 7: Solid Tumors Thiotep
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430 Chapter 7: Solid Tumors E 100 0
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432 Chapter 7: Solid Tumors course
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434 Chapter 7: Solid Tumors boplati
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436 Chapter 7: Solid Tumors INTRODU
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438 - Chapter 7: Solid Tumors Table
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440 Chapter 7: Solid Tumors seeded
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442 Chapter 7: Solid Tumors DISCUSS
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444 Chapter 7: Solid Tumors 10. Di
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446 Chapter 7: Solid Tumors plasma
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Autologous Stem Cell Transplantatio
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Keystone 451 hypertension, anemia,
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Fassas et al. 453 INTRODUCTION Mult
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Fassas et al. Table 2. Stem cell mo
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Table 3. Toxicity after stem cell i
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Fassas et al. Table 5. Trial 1: cha
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Fassas et al. MS PROGRESSION FREE S
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Fassas et al. ic or autologous bone
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1 2 1 6 EAE. Burt et al. 465 Becaus
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Burt et al. Since cyclophosphamide
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Burt et al. 469 toxicity study, we
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Burt et dl. All 23. Mor F, Cohen IR
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Hasler, Gratwohl, and Tyndall an ev
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Hasler, Gratwohl, and Tyndall 475 B
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Kuis, Wulffraat, and Sanders 477 st
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Kuis, Wulffraat, and Sanders neousl
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CHAPTER 9 LONG-TERM EFFECTS
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484 Chapter 9: Long-Term Effects po
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486 Chapter 9: Long-Term Effects Ta
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488 Chapter 9: Long-Term Effects ml
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490 Chapter 9: Long-Term Effects 4.
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492 Chapter 9: Long-Term Effects us
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494 Chapter 9: Long-Term Effects AB
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Page 532 and 533:
498 Chapter 9: Long-Term Effects En
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500 Chapter 9: Long-Term Effects Rl
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502 Chapter 9: Long-Term Effects RE
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504 Chapter 9: Long-Term Effects A,
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Long-Term Follow-Up of Autologous T
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CHAPTER 10 GRAFT MANIPULATION
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514 Chapter 10: Graft Manipulation
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Stem Cell Reinfusion Over Two Conse
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Final Report of the First Prospecti
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Canine Hematopoietic Stem Allograft
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Sandmaier et al. 603 The resultant
Page 639 and 640:
Sandmaier et al. 605 synthesis path
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Sandmaier et al. 607 interactions o
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Sandmaier et al. 1991. 2. Burchenal
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87:3508-3513,1996. Sandmaier et al.
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Giralt, Khouri, and Champlin Table
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Giralt, Khouri, and Champlin seven
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1.0 3 0.2 Giralt, Khouri, and Champ
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CHAPTER 12 GENE THERAPY
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622 Chapter 12: Gene Therapy INTROD
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624 Chapter 12: Gene Therapy RESULT
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626 Chapter 12: Gene Therapy envisi
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628 Chapter 12: Gene Therapy cer in
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A Vaccine of Melanoma Peptide Loade
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B43(anti-CD 19)-Gen i stein Immunot
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Targeting Immunotherapy for the Tre
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McGuinness andArceci 637 modified m
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McGuinness andArceci 639 leukemic c
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McGuinness and Arced 641 in G418. T
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McGuinness andArceci 643 Figure 2
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mRNA for hB7-1 (1491 bp) mRNA for C
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McGuinness and Arced CD80PE C080PE
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McGuinness andArceci 649 8. Robert
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McGuinness andArceci immune respons
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McGuinness andArceci 75. Jubinsky F
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Slavin et al. 655 up suggests, as p
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Slavin et al. 657 was a phase lib c
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Slavin et al. presented, appears to
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Antitumor Immunotherapy in Autologo
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Klingemann et al. 663 Table 3. Meth
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CHAPTER 14 RADIOIMMUNOTHERAPY
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668 Chapter 14: Radioimmunotherapy
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Selection of Radioisotopes, Chelate
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Radioimmunotherapy of Common Epithe
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CHAPTER 15 NEW AVENUES
Page 732 and 733: 698 Chapter 15: New Avenues Table 1
Page 734 and 735: 700 Chapter 15: New Avenues An alte
Page 736 and 737: 702 Chapter 15: New Avenues who can
Page 738 and 739: 704 Chapter 15: New Avenues myeloid
Page 740 and 741: 706 Chapter 15: New Avenues 48. Gir
Page 742 and 743: Emerging Viral Infections in Blood
Page 744 and 745: 710 Chapter 15: New Avenues influen
Page 746 and 747: 712 Chapter 15: New Avenues Among a
Page 748 and 749: 714 Chapter 15: New Avenues physica
Page 750 and 751: 716 Chapter 15: New Avenues respira
Page 752 and 753: Minimal Therapy Models of Transplan
Page 755: CHAPTER 16 SUMMARIES
Page 758 and 759: 724 Chapter 16: Summaries although
Page 760 and 761: 726 Chapter 16: Summaries use of po
Page 762 and 763: 728 Chapter 16: Summaries Table 1.
Page 770 and 771: 736 Chapter 16: Summaries IL-15. Th
Page 772 and 773: 738 Chapter 16: Summaries Patterns
Page 774 and 775: 740 List of Participants Thomas L.
Page 776 and 777: 742 List of Participants Sergio A.
Page 778 and 779: 744 List of Participants Hans Marti
Page 780 and 781: 746 List of Participants David P. S
Page 784 and 785: 750 Author Index Hurd, D.D. 483 Kui
Page 786 and 787: 752 Author Index Stiff, Patrick J.
Page 788 and 789: 754 Key Word Index Hematologic mali
Page 792: ISBN 1-891524-04-6
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