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Gorin 495<br />

ABMT IN AL<br />

Engraftment on Platelets according to status<br />

0 5 10 15 20 25 30 35 40 45<br />

Months<br />

CTU Paris, St Antoine<br />

Figure 2<br />

purging <strong>and</strong> the dose of mafosfamide used had no impact. The CFU-GM dose<br />

recovery postpurging <strong>and</strong> the dose actually infused influenced the relapse<br />

incidence, a lower incidence being observed for a lower CFU-GM residual dose<br />

postpurging (Fig. 5). After inclusion of these variables in the Cox proportional<br />

hazard model, only four factors appeared significant, the dose of <strong>marrow</strong> submitted<br />

to purging, the dose of <strong>marrow</strong> postpurging actually infused, the CFU-GM<br />

recovery postpurging, <strong>and</strong> the age of the patient (Table 8).<br />

Table 1. Treatment with mafosfamide (n=195)<br />

Higher mafosfamide dose<br />

Lower mafosfamide dose<br />

Fraction of patients engrafted<br />

PMN Platelets<br />

30 days 60 days 6 months 12 months P value<br />

50 ±5 88 ±3<br />

76 ± 5 89 ± 3<br />

64 ± 6 74 ± 5<br />

83+4 87 ±4<br />

0.03<br />

0.01

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