autologous blood and marrow transplantation - Blog Science ...

Table 4. Hematopoietic recovery following high-dose therapy
Prince et al. 311
All cycles
combined Cycle I Cycle 2 Cycle 3 P value* P value t
n 109 42 37 28
ANC
>0.5X10 9
/L 10 (7-26) 10 (8-19) 10 (8-26) 10 (7-14) 0.1081 0.5233
>1.0X10 9
/L 10 (8-28) 10 (8-20) 10 (9-28) 10 (8-15) 0.2027 0.5545
Platelets
>20X10 9
/L 13 (8-38) 13 (8-25) 13 (9-38) 14(10-21) 0.0644 0.4496
>50X10 9
/L 19(10-41) 17 (10-32) 20(11^10) 21 (12-41) 0.0013 0.0887
>100X10 9
/L 25 (10-152) 23 (10-45) 27 (13-124) 29 (14-152) 0.0123 0.0731
*Repeated-measures ANOVA for patients undergoing all three cycles; flog rank test of
recovery (see Figs. 1 and 2).
4 and Fig. 1). G-CSF was required for a median of 11 days (range 6-32). Febrile
neutropenia occurred after 67% of all cycles and, when it occurred, lasted for a
median of 3 days (range 1-16). Admission to hospital was required after 78% of
cycles, with a median stay in hospital of 5 days (range 2 -20). The reason for
admission into hospital was febrile neutropenia in 84% of cases.
Platelet recovery. The median time to platelets >20X10 9
/L, 50X10 9
/L, and
100X10 9
/L was 13 (range 8-38), 19 (range 10-41), and 25 days (range 10-152),
respectively (Table 4 and Fig. 1). A median of two platelet transfusions and two
packed red blood cell transfusions were required after each cycle of treatment.
There was significant slowing in platelet recovery between cycles. Analysis
comparing time to recovery of platelets after each consecutive cycle of high-dose
therapy (repeated-measures ANOVA), demonstrated that although recovery of platelets
to >20X10 9
/L was not significantly slowed (/ >
=0.0644), recovery to >50X10 9
/L
(/>=0.0013) and >100X 10 9
/L (/>=0.0123) was slowed (Table 4 and Fig. 2).
Autograft CD34 content and ANC hematopoietic recovery. The range of
autograft CD34 +
correlation between CD34 +
cells infused was 0.41 to 9.61X10 9
/kg per cycle. There was a
cell count and ANC recovery to >0.5X10 9
/L
(Spearman correlation: r=0.4904, P1.0X10 9
/L (r=0.5015,
P