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UC Davis General Catalog, 2006-2008 - General Catalog - UC Davis

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Microbiology 373<br />

Ted Powers, Ph.D., Assistant Professor<br />

Irwin H. Segel, Ph.D., Professor<br />

Emeriti Faculty<br />

Paul Baumann, Ph.D., Professor Emeritus<br />

Robert E. Hungate, Ph.D., Professor Emeritus<br />

John L. Ingraham, Ph.D., Professor Emeritus<br />

JaRue S. Manning, Ph.D., Professor Emeritus<br />

Allen G. Marr, Ph.D., Professor Emeritus<br />

David Pratt, Ph.D., Professor Emeritus<br />

Merna R. Villarejo, Ph.D., Professor Emerita<br />

Affiliated Faculty<br />

Karen L. Gerhart, Ph.D., Lecturer<br />

Eric D. Mann, Ph.D., Lecturer<br />

The Major Program<br />

Microbiology is the branch of biology that deals<br />

with bacteria, yeasts and other fungi, algae, protozoa,<br />

and viruses. These microorganisms are ubiquitous<br />

in nature and play a crucial role in areas such<br />

as agriculture, biotechnology, ecology, medicine,<br />

and veterinary science. The field of microbiology<br />

contributes to areas of fundamental inquiry such as<br />

biochemistry, cell biology, evolution, genetics,<br />

molecular biology, pathogenesis, and physiology.<br />

The ease and power of simultaneous genetic and<br />

biochemical analysis of microbes led to the emergence<br />

of the new disciplines of molecular biology<br />

and molecular genetics, and spawned the new<br />

industry of biotechnology.<br />

The Program. Both undergraduate major programs<br />

provide a balance of studies in microbiology,<br />

with appropriate courses in mathematics and physical<br />

sciences. The A.B. degree program emphasizes<br />

the biology of bacteria, while the B.S. degree program<br />

includes more biochemistry and related course<br />

work. Either program, with judicious course selection,<br />

is appropriate for students contemplating a<br />

career in medicine or various allied health professions<br />

including medical technology, or teaching. The<br />

B.S. program is especially well suited for students<br />

who want a professional career in microbiology, or<br />

who wish to pursue graduate education in a biological<br />

science discipline. The choice of a major program<br />

and its suitability for particular career options<br />

should be discussed with a major adviser.<br />

Career Alternatives. A bachelor’s degree in<br />

microbiology is excellent preparation for a career in<br />

biotechnology, pharmacology, agriculture, and the<br />

food industry. It also provides a strong background<br />

for students wishing to continue on to professional<br />

studies in medicine and the other health sciences.<br />

A.B. Major Requirements:<br />

UNITS<br />

Preparatory Subject Matter.............. 43-57<br />

Biological Sciences 1A-1B-1C................ 15<br />

Chemistry 2A-2B.................................. 10<br />

Chemistry 8A-8B or 118A-118B-<br />

118C .............................................. 6-12<br />

Mathematics 16A-16B, 17A-17B or<br />

21A-21B............................................ 6-8<br />

Physics 1A-1B or 7A-7B-7C ................ 6-12<br />

Depth Subject Matter ....................... 37-45<br />

Biological Sciences 101, 102, 103........ 10<br />

Microbiology 102, 102L, 105, 105L,<br />

140.................................................... 16<br />

Microbiology 162 or Pathology,<br />

Microbiology, and Immunology 128...... 3-4<br />

Three additional courses from Food Science<br />

and Technology 104; Medical Microbiology<br />

115, 116, 130; Microbiology 100, 120,<br />

150, 155L, 160, 170; Molecular and<br />

Cellular Biology 120L; Pathology,<br />

Microbiology, and Immunology 127; Plant<br />

Pathology 120, 130, 148, 150; Soil Science<br />

111; Statistics 100, 102.................... 8-15<br />

Total Units for the Major ................ 80-102<br />

B.S. Major Requirements:<br />

UNITS<br />

Preparatory Subject Matter.............. 60-70<br />

Biological Sciences 1A-1B-1C................ 15<br />

Chemistry 2A-2B-2C............................. 15<br />

Chemistry 8A-8B or 118A-118B-<br />

118C ...............................................6-12<br />

Mathematics 16A-16B-16C or 17A-17B-<br />

17C .................................................9-12<br />

Physics 7A-7B-7C................................. 12<br />

Statistics 13, 32, 100 or 102................3-4<br />

Depth Subject Matter .......................47-51<br />

Biological Sciences 101, 102, 103,<br />

104 ................................................... 13<br />

Molecular and Cellular Biology 120L ....... 6<br />

Microbiology 102, 102L, 105, 105L .... 13<br />

Two courses from Microbiology 140, 150,<br />

or 170 ................................................. 6<br />

Microbiology 162 or Pathology,<br />

Microbiology, and Immunology 128 ......3-4<br />

Two courses from Food Science and<br />

Technology 104; Microbiology 120, 140,<br />

150, 155L, 160, 170, Pathology,<br />

Microbiology, and Immunology 127; Soil<br />

Science 111........................................6-9<br />

Total Units for the Major ..............107-121<br />

Master Adviser. M.L. Wheelis in 2033D Sciences<br />

Lab Building<br />

Honors and Honors Program. M.L. Wheelis<br />

Teaching Credential Subject Representative.<br />

M.L. Wheelis; see the Teaching Credential/M.A.<br />

Program on page 102.<br />

Graduate Study. The Graduate Group in Microbiology<br />

offers programs of study and research leading<br />

to the M.S. and Ph.D. degrees.<br />

Strong preference is given to doctoral applicants.<br />

The group offers study in general microbiology,<br />

microbial physiology, microbial genetics, molecular<br />

mechanisms of microbial regulation, molecular<br />

mechanisms of microbial pathogenesis, immunology,<br />

virology, and recombinant DNA technology. For<br />

information on the graduate study and undergraduate<br />

preparation for the program contact a graduate<br />

adviser or the Chairperson of the Group.<br />

Related Courses. The offerings of the Section of<br />

Microbiology are augmented by courses and faculty<br />

of Evolution and Ecology; Food Science and Technology;<br />

Land, Air, and Water Resources; Medical<br />

Microbiology; Medicine and Epidemiology; Molecular<br />

and Cellular Biology; Pathology, Microbiology,<br />

and Immunology; Plant Biology; Plant Pathology;<br />

Viticulture and Enology.<br />

Faculty of the Section of Microbiology also teach or<br />

participate in the following courses: Biological Sciences<br />

1A, 10, 101 and 104.<br />

Courses in Microbiology (MIC)<br />

Lower Division Courses<br />

10. Natural History of Infectious Diseases<br />

(3)<br />

Lecture—3 hours. Topics in the natural history of<br />

infectious diseases principally affecting humans.<br />

Introduction to infectious microbial agents, ecology,<br />

epidemiology, and induction of disease. Focus on<br />

diseases of a contemporary nature. For students not<br />

majoring in the biological sciences. GE credit: Sci-<br />

Eng.—II. (II.)<br />

98. Directed Group Study (1-5)<br />

Prerequisite: consent of instructor. Primarily for lower<br />

division students. (P/NP grading only.)<br />

99. Special Study for Undergraduates (1-5)<br />

(P/NP grading only.)<br />

Upper Division Courses<br />

100. Chemical and Biological Weapons (3)<br />

Lecture/discussion—3 hours. Prerequisite: upper<br />

division standing. Ancient and modern history of<br />

chemical and biological weapons; mechanism of<br />

action; tactical and strategic uses; riot-control<br />

agents; international legal constraints; disarmament<br />

and nonproliferation; genomics and the future. GE<br />

credit: SciEng or SocSci.—II. (II.) Wheelis<br />

102. <strong>General</strong> Bacteriology (4)<br />

Lecture—4 hours. Prerequisite: Biological Sciences<br />

1A and Chemistry 8B or Chemistry 118B (may be<br />

taken concurrently). Survey of the biology of bacteria<br />

and viruses, including bacterial structure, metabolism,<br />

physiology, genetics, and evolution; viral<br />

structure and replication; the role of bacteria in global<br />

element cycles; and the role of microbes in infectious<br />

disease.—I, II, III. (I, II, III.)<br />

102L. <strong>General</strong> Bacteriology Laboratory (3)<br />

Lecture/laboratory—7 hours. Prerequisite: course<br />

102 (may be taken concurrently) and consent of<br />

instructor. Introduction to principles and laboratory<br />

methods employed in working with microorganisms.<br />

For students planning to continue the study of microbiology<br />

or to use microorganisms as tools for the<br />

study of genetics and biochemistry.—I, II, III.<br />

105. Bacterial Diversity (3)<br />

Lecture—3 hours. Prerequisite: consent of instructor;<br />

courses 102 and 102L; Biological Sciences 102;<br />

Biological Sciences 103 recommended. Survey of<br />

the major groups of bacteria emphasizing diversity<br />

of energy metabolism, morphology and natural history.<br />

Not open for credit to students who completed<br />

course 105 in 2005 or earlier.—II. (II.) Parales,<br />

Wheelis<br />

105L. Bacterial Diversity Laboratory (3)<br />

Laboratory—9 hours. Prerequisite: consent of instructor;<br />

courses 102 and 102L; course 105 (may be<br />

taken concurrently); Biological Sciences 102; Biological<br />

Sciences 103 recommended. Laboratory—nine<br />

hours (eight hours scheduled lab periods; one hour<br />

during open laboratory). Isolation and characterization<br />

of bacterial strains from various habitats.<br />

Includes methods for determination of evolutionary<br />

relationships among groups. Not open for credit to<br />

students who completed course 105 in 2005 or earlier.—II.<br />

(II.) Nelson, Parales<br />

120. Microbial Ecology (3)<br />

Lecture—3 hours. Prerequisite: course 105, Biological<br />

Sciences 102. Interactions between non-pathogenic<br />

microorganisms and their environment,<br />

emphasizing physiological and metabolic characteristics<br />

of various groups and their adaptation to and<br />

modification of specific habitats.—III. (III.) Wheelis<br />

120L. Microbial Ecology Laboratory (2)<br />

Laboratory—6 hours; one optional overnight weekend<br />

field trip. Prerequisite: course 120 (may be<br />

taken concurrently); consent of instructor. Study of<br />

prokaryotic microorganisms from certain habitats.<br />

One-half of laboratory effort will consist of organized<br />

experiments on ecologically important microbial<br />

activities. For remaining one-half, research<br />

projects will be done on student selected specific<br />

habitats of microorganisms. Limited enrollment. Not<br />

offered every year.<br />

140. Bacterial Physiology (3)<br />

Lecture—3 hours. Prerequisite: Biological Sciences<br />

101, 102, 103 (may be taken concurrently); course<br />

102 recommended (may be taken concurrently).<br />

Fundamentals of bacterial growth and bacterial<br />

responses to environmental stresses. Topics will<br />

include carbon and nitrogen regulation, growth rate<br />

control, post-exponential growth, and motility and<br />

chemotaxis. Not open for credit to students who<br />

have completed course 130A.—I. (I.) Singer, Meeks<br />

150. Bacterial Genetics (3)<br />

Lecture—3 hours. Prerequisite: Biological Sciences<br />

101, 102, Biological Sciences 103 or course 140;<br />

course 102 recommended (may be taken concurrently).<br />

Molecular genetics of enterobacteria and<br />

their viruses. Isolation of mutants; genetic exchange<br />

and mapping; complementation; suppression; transposons;<br />

gene expression and regulation; and<br />

genomics. Examples illustrate applications to molecular<br />

cloning of recombinant DNA, and to the study<br />

of bacterial pathogenesis.—II. Roth, Stewart<br />

155L. Bacterial Physiology Lab (4)<br />

Lecture/discussion—1 hour; laboratory—8 hours.<br />

Prerequisite: course 140 or 150, 102L, consent of<br />

instructor. Physiology and genetics of bacteria. Isolation<br />

and characterization of mutant strains. Mapping<br />

Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2007-<strong>2008</strong> offering in parentheses<br />

<strong>General</strong> Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience

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