UC Davis General Catalog, 2006-2008 - General Catalog - UC Davis

380 Molecular and Cellular Biology
The Program. The genetics program begins with
the four-course, upper division core curriculum that
provides an introduction to the principles of genetics,
biochemistry, and cell biology. Students then take
additional upper division courses in specialized
areas of modern genetics including gene expression,
evolution, development, human genetics and genomics,
as well as a laboratory course in the principles
of genetics. Additional upper division courses in biological
sciences, as well as internship/research
coursework can be chosen to fulfill required elective
units.
Career Alternatives. The genetics degree provides
suitable preparation for a wide variety of
careers, including teaching, research, work with biotechnology
companies, medicine, and all the health
sciences. It is also an excellent background for students
wishing to continue their education in a graduate
program, a teacher-training program, medical
school, veterinary school, or other professional
schools.
B.S. Major Requirements:
UNITS
Preparatory Subject Matter ............. 57-66
Biological Sciences 1A-1B-1C ................15
Chemistry 2A-2B-2C or 2AH-2BH-
2CH ...................................................15
Chemistry 8A-8B or 118A-118B-
118C .............................................. 6-12
Mathematics 16A-16B-16C or 21A-21B-
21C ................................................ 9-12
Physics 7A-7B-7C .................................12
Depth Subject Matter ....................... 48-49
Biological Sciences 101, 102, 103,
104....................................................13
Molecular and Cellular Biology 160L,
164...................................................... 7
Evolution and Ecology 100...................... 4
One course from Molecular and Cellular
Biology 161 (recommended) or 121 ........ 3
Two courses from Molecular and Cellular
Biology 162, 163, 182 or Evolution and
Ecology 102....................................... 6-7
Statistics 100 ......................................... 4
Restricted Electives................................11
Upper division courses in genetics or other
fields relevant to the student’s interest
chosen in consultation with the adviser. No
more than 4 units of 192, 193, 198, or
199 can be used for credit in this category.
Total Units for the Major.............. 105-115
Master Adviser. J.E. Natzle
Advising Center for the major is located in 156
Briggs Hall (530) 752-0202.
Graduate Study. The Graduate Group in Genetics
offers study and research leading to the M.S. and
Ph.D. degrees in Genetics.
Courses in Molecular and Cellular
Biology (MCB)
Lower Division Courses
10. Introduction to Human Heredity (4)
Lecture—3 hours; discussion—1 hour. Topics in
human heredity and human gene structure and function,
including the genetic basis of human development,
causes of birth defects, mental retardation,
genetic diseases, sexual determination, development,
and behavior. GE credit: SciEng.—III. (III.)
Sanders
99. Special Study (1-5)
Independent study—3-15 hours. Prerequisite: consent
of instructor. (P/NP grading only.)
Upper Division Courses
120L. Biochemistry Laboratory (6)
Laboratory—10 hours; lecture—2 hours; laboratory/discussion—1
hour. Prerequisite: Biological Sciences
103 (may be taken concurrently). Introduction
to laboratory methods and procedures employed in
studying biochemical processes. Designed for students
who need experience in the use of biochemical
techniques as laboratory tools.—I, II, III. (I, II, III.)
Gasser, Hilt, J.C. Lagarias, L. Morand, Rubin, L.
Segel
121. Molecular Biology of Eukaryotic Cells
(3)
Lecture—3 hours. Prerequisite: Biological Sciences
101 and 103. Structure, expression, and regulation
of eukaryotic genes. Chromosome structure and replication;
gene structure, transcription, and RNA processing;
protein synthesis and translation control;
development, immune system, and oncogenes. Not
open for credit to students who have completed
Molecular and Cellular Biology 161.—II, III. (II, III.)
Dahmus, Gasser, Harmer
122. Structure and Function of Proteins (3)
Lecture—3 hours. Prerequisite: course 120L, Biological
Sciences 103. Correlation of structure and biological
function. Molecular models of enzymes that
explain their physiological functioning. Physical and
chemical methods used in determining protein structure.
Function as measured by kinetic and binding
models and as affected by physiological considerations.—I.
Baldwin, Stahlberg
123. Behavior and Analysis of Enzyme and
Receptor Systems (3)
Lecture—3 hours. Prerequisite: Biological Sciences
103. Introduction to the principles of enzyme kinetics
and receptor-ligand interactions with emphasis on
metabolic regulation and data analysis. Topics
include simultaneous equilibria, chemical and
steady-state kinetics, allosteric enzymes, mulitreactant
systems, enzyme assays, membrane transport
and computer-assisted simulations and analyses.—I,
III. (I, III.) I. Segel, Wilson
126. Plant Biochemistry (3)
Lecture—3 hours. Prerequisite: Biological Sciences
1C or the equivalent, and Biological Sciences 103.
The biochemistry of important plant processes and
metabolic pathways. Discussion of methods used to
understand plant processes, including use of transgenic
plants. (Same course as Plant Biology 126.)—
III. (III.) Abel, Callis
138. Undergraduate Seminar in
Biochemistry (1)
Seminar—1 hour. Prerequisite: Biological Sciences
103. Discussion of the historical developments of
modern biochemistry or current major research problems.
May be repeated twice for credit when topic
differs. (P/NP grading only.)—I, II, III. (I, II, III.) Callis,
Gasser, Kaplan, Scholey
140L. Cell Biology Laboratory (4)
Lecture—2 hours; laboratory—6 hours. Prerequisite:
Biological Sciences 104 (may be taken concurrently).
Exercises illustrating the principles of cell
biology with emphasis on light microscopy.—II. (II.)
Nunnari
142. Advanced Cell Biology: Contractile
and Motile Systems (4)
Lecture—3 hours; term paper. Prerequisite: Biological
Sciences 102, 104 (may be taken concurrently);
Mathematics 16B. Advanced cell biology with
emphasis on molecular, biophysical and cellular
properties of contractile and motile systems.
143. Cell Biophysics (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, 102, 103, 104. Physical principles underlying
observations and mechanisms of cell motility. Organization
of biomolecules into higher order subcellular
structures that function as macromolecular
machines. Examples include cytoskeletal filaments,
polymer-motor systems, neurites, axonemes and
mitotic spindles.—I. (I.) Scholey
144. Mechanisms of Cell Division (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, 102, 104. The molecules and mechanisms that
allow eukaryotic cells to coordinate cell growth,
DNA replication, segregation of chromosomes and
cell division.—II. (II.) McNally
145. Assembly and Function of Cell
Signaling Machinery (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, 102, 104. Molecular basis of cell signaling,
including positioning of cellular machinery, components
of various signaling pathways, and downstream
effects of signaling on cell adhesion, cell
differentiation, and programmed cell death.—III.
(III.) Erickson
148. Undergraduate Seminar in Cell
Biology (2)
Seminar—2 hours. Prerequisite: upper division
standing in the biological sciences or a related discipline.
Student reports on current topics in cell biology
with emphasis on integration of concepts,
synthesis, and state-of-the-art research approaches.
Reviews of literature and reports of undergraduate
research may be included. May be repeated for
credit. (P/NP grading only.)
150. Embryology (4)
Lecture—4 hours. Prerequisite: Biological Sciences
101 and concurrent enrollment in course 150L. The
events and mechanisms of embryonic development,
including fertilization, morphogenesis, cell differentiation
and organogenesis, with emphasis on vertebrates.—I,
III. (I, III.) Armstrong, Edwards
150L. Laboratory in Vertebrate Embryology
(1)
Laboratory—3 hours. Prerequisite: concurrent enrollment
in course 150. The comparative analysis of the
embryonic development of vertebrates. (P/NP grading
only.)—I, III. (I, III.) Edwards
158. Undergraduate Seminar in
Developmental Biology (2)
Seminar—2 hours. Prerequisite: upper division
standing in the biological sciences or a related discipline.
Student reports on current topics in cell biology
with emphasis on integration of concepts,
synthesis, and state-of-the-art research approaches.
Reviews of literature and reports of undergraduate
research may be included. May be repeated for
credit. (P/NP grading only.)
160L. Principles of Genetics Laboratory (4)
Laboratory—6 hours; lecture—2 hours. Prerequisite:
Biological Sciences 101. Laboratory work in basic
and molecular genetics including gene mapping and
isolation of mutants. Not open for credit to students
who have completed Genetics 100L.—I, II, III. (I, II,
III.) Britt, Burtis, Kiger, Kimbrell, Natzle, Rose, Sanders,
Sundaresan
161. Molecular Genetics (3)
Lecture—3 hours. Prerequisite: Biological Sciences
101, Biological Sciences 102 may be taken concurrently.
Molecular mechanisms for propagation and
expression of the genome in eukaryotic and prokaryotic
model organisms. How genetic and molecular
tools, both classical and modern, are applied to the
study of gene structure, function, and regulation. Not
open for credit to students who have completed
course 121.—II. (II.) Powers
162. Human Genetics (3)
Lecture—3 hours. Prerequisite: course 161 (preferred)
or 121, 164. Human molecular genetic variation,
molecular basis of metabolic disorders,
chromosome aberrations and consequences, analysis
of the human genome, and computational techniques
of genetic analysis.—I. (I.) Chedin
163. Developmental Genetics (3)
Lecture—3 hours. Prerequisite: course 161 (preferred)
or 121, course 164. Current aspects of
development genetics. Historical background and
current genetic approaches to the study of development
of higher animals.—II. (II.) Natzle
164. Advanced Eukaryotic Genetics (3)
Lecture—3 hours. Prerequisite: course 161 or 121.
The five basic operations of genetic analysis: mutation,
segregation, recombination, complementation,
and regulation. Emphasis on the theory and practice
of isolating and analyzing mutations, as well as
understanding mechanisms underlying both Medelian
and epigenetic inheritance.—III. (III.) Burgess
178. Undergraduate Seminar in Molecular
Genetics (1)
Seminar—1 hour. Prerequisite: upper division standing,
completion of Biological Sciences 101, course
160L, and completion or concurrent enrollment in
course 161. Discussion of current topics in molecular
genetics to show advanced applications of basic
Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2007-2008 offering in parentheses
General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience