PDF file: EURASNET Annual Report 2008

will further improve their U7-based exon skipping strategy.Concerning the analysis of therole of PTB in pseudoexonsplicing, the group has juststarted a study to look atwhether PTB-nPTB or otherneuron-specific splicingregulators affect the splicing ofagrin, a protein important forsynapse establishment and/ormaintenance. (month 42)225 Eperon's group will investigate 14 42 on target Tazithe possibility of using TOES tostimulate splicing of exonsdamaged by mutation in cysticfibrosis (collaboration withBaralle lab) and of undamagedskipped exons in genes withroles in the development ofleukaemia. (month 42)229 Feasibility study to use mass 15 42 in progress Séraphinspectrometrey based analysis for"Spatial Proteomics" wherequantification of the relativedistribution of cellular proteinsbetween different cellularcompartments will be analyzedin parallel (month 42)230 Identification and/or analysis of 15 42 in progress Séraphinalternative splicing by highthroughputsequencing (month42)231 Feasibility study to determine 15 42 in progress Séraphinwhether analyticalultracentrifugations can be usedto determine the assembly ofRNA binding proteins on modelRNAs (month 42)232 Experimental setup to elucidate 15 42 in progress Séraphinthe “code” of RNA interactionas mediated by RRM domains(month 42)237 Continue and further develop the 17 42 partially achieved Krämeruse of travel bursaries forstudent and postdoc exchangesfor training and participation atintra-workpackage meetings (40PMT/18 month) (month 42)(continuation of deliverable 116)238 Establishing joint PhDcommittees for PhD students inthe EURASNET. (month 42)(continuation of deliverable 16)18 42 42 Kjems246 continuous enrichment and 19 42 on target Bartaupdate of the PUS part of thewebpage; as well ascontinuous collection ofteaching material for RNAbiology247 a newsletter describing 19 34 35 Barta106