PDF file: EURASNET Annual Report 2008

More documents

Recommendations

Info

269 IFMs in 20091. “Alternative and Aberrant Splicing in neuromuscular degenerative processes”, 26-27 March, Trieste,organised by F. Baralle2. “Biophysical methods & functional genomics tools” Mouse Genomics/models 22 April, Assisi,organised by G. Toccini-Valentini and J. Valcarcel.3. “Combining computational & experimental approaches” 27-28 June, Stockholm, organised by E.Eyras & F. Allain4. “Cell Biology, signalling & AS” October, Lisbon, organised by M. Carmo-Fonseca272 2010 Second International Meeting/ Fifth Annual Meeting, April, location to be decidedWorkshops in 20101) “Alternative Splicing in Neurodegenerative Diseases”, Jerusalem, Israel, February 2010, organised byG. Ast and H. Soreq2) "Influence of genetic variations on alternative splicing", organised by S. Stamm (hands-on with kit formini-gene assays), date to be decided3) Computational and experimental approaches to study RNA-protein interactions and structure.Poznan, Poland, June/July, organised by J. BujnickiIFMs in 2010:1. “Mis-splicing: Disease and Therapeutics”, Cambridge, UK, July/September 2009, organised by C.Smith and D. Schumperli2. “Cell Biology, signalling & AS” - Javier and Karla, Dresden or Edinburgh, 2 nd half of 2010273
17. Staff Exchange and TrainingWorkpackage description (month 37-54)Workpackage number 17 Start date or starting event: 4 monthParticipant idallPerson months 28.5Objectives• To increase the technical competence of PhD students and postdocs in the EURASNET by giving themopportunities to learn state-of-the-art techniques in other member laboratories.• To encourage staff exchange among EURASNET laboratories for the purpose of training specific techniques.• To promote scientific collaborations, in particular those of a multidisciplinary nature, by supporting theexchange of personnel between EURASNET member laboratories.Description of workStaff exchange and training in the groups of EURASNET participants will be continued and the travel bursarieswill also be used for participation of students and postdocs at intra-workpackage meetings. EURASNETmembers will be reminded at regular intervals about these possibilities. As predicted, the number of trainingexchanges has doubled from 2006 to 2007; however most exchanges are relatively short (less than two weekson average in 2007), resulting a low number of PMT. We expect a further increase in staff exchange afterinitiation of new collaborations between EURASNET groups. In addition, with workpackages evolving, weexpect that travel bursaries will increasingly be used for attendance at intra-workpackage meetings. Severalrequests for 2008 have already been received.Deliverables237 Continue and further develop the use of travel bursaries for student and postdoc exchanges for training andparticipation at intra-workpackage meetings (40 PMT/18 month) (month 42) (continuation of deliverable 116)351 Continue and further develop the use of travel bursaries for student and postdoc exchanges for training andparticipation at intra-workpackage meetings and EURASNET workshops (40 PMT/18 month) (month 54)(continuation of deliverable 237)274
Page 3 and 4:
TABLE OF CONTENTSA. PERIODIC ACTIVI
Page 5 and 6:
1 PUBLISHABLE EXECUTIVE SUMMARY EUR
Page 7 and 8:
Dr. Davide Gabellini(28) Swiss Inst
Page 9 and 10:
WP7 Molecular characterization of s
Page 11 and 12:
To identify protein-protein interac
Page 13 and 14:
expressed in a particular tissue. T
Page 15 and 16:
Duchenne muscular dystrophy (DMD).
Page 17 and 18:
WP21 Reachout to the broader RNA co
Page 19 and 20:
4.1 TABLE OF MILESTONES JPA MONTH 2
Page 21 and 22:
Numerous plasmids, constructs, extr
Page 23 and 24:
collaboration between EURASNET and
Page 25 and 26:
5.1 WORK PACKAGE REPORTSWork Packag
Page 27 and 28:
• Ongoing regular addition of new
Page 29 and 30:
Work Package 4 The Alternative Spli
Page 31 and 32:
Work Package 6 In silico approaches
Page 33 and 34:
alternative splicing.162 Compare sp
Page 35 and 36:
33 Agreement on pre-mRNA substrates
Page 37 and 38:
its numerous binding sites on both
Page 39 and 40:
Work Package 8 Genome-wide Analyses
Page 41 and 42:
173 Further development of data ana
Page 43 and 44:
Problems and explanations for delay
Page 45 and 46:
eveal that there is a dramatic chan
Page 47 and 48:
Work Package 10 Post-translational
Page 49 and 50:
mutational analysis that led to the
Page 51 and 52:
Isolation of an active step I splic
Page 53 and 54:
FBP11 and 21 with these sequences.
Page 55 and 56:
Similarly to what observed for SF2/
Page 57 and 58:
prp45-113 mutant, which is compatib
Page 59 and 60:
cell lines. In contrast in the pres
Page 61 and 62:
genes with roles in the development
Page 63 and 64:
Structural analyses of several RRMs
Page 65:
Work Package 17 Staff Exchange and
Page 69 and 70:
Barralle's lab, Krämer is acting a
Page 71 and 72:
alternative splicing) and higher ed
Page 73 and 74:
Student Symposium “Decision Makin
Page 75 and 76:
variation and suitability for use w
Page 77 and 78:
Following feedback from members we
Page 79 and 80:
Invited seminars: In addition to me
Page 81 and 82:
Publications 2008Author Title Publi
Page 83 and 84:
Author Title Publication EURASNET P
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Minutes of the General Assembly dec
Page 96 and 97:
241 Evaluate available careerdevelo
Page 98 and 99:
156 The EURASNET memberStamm publis
Page 100 and 101:
y coarse-grained foldingsimulation.
Page 102 and 103:
overexpressor and mutant lines(mont
Page 104 and 105:
machinery with particularrespect to
Page 106 and 107:
alternative splicing, using theEDI
Page 108 and 109:
contemporary findings withinthe EUR
Page 110 and 111:
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
Page 118 and 119:
Licht K, Medenbach J, Lührmann R,K
Page 120 and 121:
Page 122 and 123:
9 TABULAR OVERVIEW OF MAJOR COST IT
Page 124 and 125:
total costs * 18.891,12 52778.60 41
Page 126 and 127:
other (the rest) 48,57 0 56.539,43t
Page 128 and 129:
travel 6.964,91overhead 3.081,07oth
Page 130 and 131:
Participant 1A Type of expenditure
Page 132 and 133:
Participant 1B - Karla Neugebauera)
Page 134 and 135:
Participant 2 - Juan Valcarcela) Wo
Page 136 and 137:
Participant 3 - Stefan Stamma) Work
Page 138 and 139:
Participant 4 - Göran Akusjärvia)
Page 140 and 141:
Participant 5A/B - Peer Bork/Rolf A
Page 142 and 143:
Major cost items• ResearchPersonn
Page 144 and 145:
Participant 7 - Francisco Barallea)
Page 146 and 147:
Francisco Baralle gave a talk to a
Page 148 and 149:
alternative splicing on human disea
Page 150 and 151:
J. Beggs has had frequent contact w
Page 152 and 153:
Page 154 and 155:
Page 156 and 157:
Participant 12A - Jamal Tazia) Work
Page 158 and 159:
Participant 12B - Bertrand Séraphi
Page 160 and 161:
Participant 12C - Christiane Branla
Page 162 and 163:
Participant 12D - Edouard Bertranda
Page 164 and 165:
Participant 13 - Daniel Schümperli
Page 166 and 167:
Participant 14 - John W. S. Browna)
Page 168 and 169:
Participant 15 - Javier F. Cáceres
Page 170 and 171:
• ResearchPersonnelName WP Person
Page 172 and 173:
MiscellaneousOligonucleotidesUse of
Page 174 and 175:
Major cost items• ResearchConsuma
Page 176 and 177:
Page 178 and 179:
Participant 21 - Angela Krämera) W
Page 180 and 181:
Participant 22 - Angus Lamonda) Wor
Page 182 and 183:
Participant 23 - Chris Smitha) Work
Page 184 and 185:
ChemicalsEnzymesLaboratory supplies
Page 186 and 187:
Participant 26 - Didier Auboeufa) W
Page 188 and 189:
tool for the molecular analysis of
Page 190 and 191:
Participant 29 - Frédéric Allaina
Page 192 and 193:
protein and instead possesses the d
Page 194 and 195:
+ overhead 4.730= total eligible co
Page 196 and 197:
Claudia Tamaro (PhD) has begun work
Page 198 and 199:
ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 200 and 201:
Direct eligible costs 53.240,48 0,0
Page 202 and 203:
Direct eligible costs 18.720,07 0,0
Page 204 and 205:
13 REPORT ON THE DISTRIBUTION OF TH
Page 206 and 207:
Report on the Distribution of the C
Page 208 and 209:
For most work packages here follows
Page 210 and 211:
pathways (eg, Reactome ).While PAND
Page 212 and 213:
The possible dependence of the effe
Page 214 and 215:
In some treatments or mutants, simi
Page 216 and 217:
Work Package 12: Mis-splicing and D
Page 218 and 219:
acid. Furthermore, using antibodies
Page 220 and 221:
At the 2007 annual meeting in Ile d
Page 222 and 223:
Partner 13 has extensively studied
Page 224 and 225: inhibitors/modulators of RNA splici
Page 226 and 227: 18 MONTH JPA: WORKPACKAGE TIMECOURS
Page 228 and 229: 15.3 GRAPHICAL PRESENTATION OF WORK
Page 230 and 231: 15.4 TABLE OF MILESTONES (MONTH 37-
Page 232 and 233: 156 The EURASNET memberStamm publis
Page 234 and 235: 194 Bertrand will analyze indetail
Page 236 and 237: 216 Aubeouf and Neugebauer willcoll
Page 238 and 239: 238 Establishing joint PhDcommittee
Page 240 and 241: 283 A unified browser for allknown
Page 242 and 243: 296 Group 12a (Branlant) willuse th
Page 244 and 245: 315 Lamond will use a FLIM-FRET bas
Page 246 and 247: 329 GROUP 7 (F. BARALLE)will contin
Page 248 and 249: 333 GROUP 27 (GABELLINI)will:1) foc
Page 250 and 251: 345 Schümperli’s group isplannin
Page 252 and 253: 366 Quarterly network e-mail atmont
Page 254 and 255: 2. Sharing Resources, Technology an
Page 256 and 257: 5. Ensuring DurabilityWorkpackage d
Page 258 and 259: 7. Molecular Characterization of Sp
Page 260 and 261: 8. Genome-wide Analyses of Splicing
Page 262 and 263: 9. Complexity of Spliceosomal Prote
Page 264 and 265: 202 Srebrow will investigate the ro
Page 266 and 267: 12. Mis-splicing and DiseaseWorkpac
Page 268 and 269: 13. Co-transcriptional Mechanisms o
Page 270 and 271: 14. Chemical Biology and Therapeuti
Page 272 and 273: 15. Development of Enabling Technol
Page 276 and 277: 18. Career DevelopmentWorkpackage d
Page 278 and 279: 20. SMEs and Technology TransferWor
Page 280 and 281: 21. Reachout to the Broader RNA Com
Page 282 and 283: 15.7 WORK PACKAGE LIST (MONTHS 37-5
Page 284 and 285: ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 286 and 287: AMU 5 29 8 42UAAR 5 145 16 1665 29
Page 288 and 289: Joint Programme of Activities RESEA
Page 290 and 291: 60 month period 18 month periodRequ
Page 292 and 293: Integration1. Young Investigator Pr
Page 294 and 295: UCAM-DBIOC 2350,000x1/3 € 50,000x
Page 296: the management team. Audit costs ar
show all

PDF file: EURASNET Annual Report 2008

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?