PDF file: EURASNET Annual Report 2008

630,000 € 180,000 € 210,000 € 45,000 €HUJI 24 630,000 € 180,000 € 210,000 € 45,000 €UCAM-DBIOC 23CERBM-GIE 25630,000 € 180,000 € 210,000 € 45,000 €TOTAL 18,900,000 € 5,400,000 € 6,300,000 € 1,350,000 €The new contractors incorporated after completion of the first and second YIP round are shown in thebudget of the Joint Program of Integration!*Partner 3 (UERLN) leaves the network, effective Feb 29, 2008. The JPA tasks of this partner areredistributed to other network members. Research funds of Partner 3 remain with the Coordinator(Partner 1a MPG) and are distributed accordingly.2. The High-Throughput-Enabling Fund“High-throughput enabling” (HTE)-Fund for securing new technologies. This special fund, amounting to€ 650,000, will be instituted. This will have two purposes: (i) to support the exploitation of highthroughputtechnologies in the study of alternative splicing, e.g., micro-array technology used for thegenome-wide identification of alternatively spliced mRNAs, as explained in detail in Section 6.2 c ofAnnex_I, and (ii) to support essential feasibility studies required for the development and effective use ofnew assay formats by NoE member groups to support the high-throughput screening of chemicalcompound libraries to identify inhibitors and modulators of splicing (Section 6.2 i). Of this fund, ourindicative proposal is that € 400,000 will be directed towards the former purpose and € 250,000 to thelatter. However, the final allocation of resources from the fund will be closely linked to the success anddevelopment of these respective projects. To ensure best practice, the progress of all projects will beregularly reviewed by the HTE-Fund Committee, with advice from the appointed external consultants, andfunding allocated accordingly to reinforce the most successful work.In the case of feasibility studies that involve the use of screening facilities at the University of Dundee,labour and material costs incurred may be paid by the NOE member for whom the study is performed;however, we note that the facility will participate on a non-profit basis. The NoE member in question canapply to the HTE-Fund Committee for reimbursement of these costs. either in whole or in part, from theHTE-Fund.The HTE-Fund of € 650,000 supporting array technology and high-throughput screening of chemicalcompound libraries will be under the administration of the Chairman of the HTE-Fund Committee. Whilethe funds are primarily intended to support the efforts of the participants in the corresponding workpackages 11 and 14, they remain also available to proposed projects by other participants. To obtainsupport from the HTE-Fund for either of the above activities, members of the NoE will in the firstinstance submit an informal written application for this support to the chairman of the HTE-FundCommittee. Applications will be considered, and allocation made, by the HTE-Fund Committee, usuallynot later than three months after receiving a request. To ensure objective and transparent criteria in thedecision-making process, the Committee's decisions will be reviewed by two members of the externalScientific Advisory Board. Any member of the NOE whose application is turned down by the committeewill have the opportunity to appeal the decision by writing to the chairman of the Scientific Advisoryboard, whose decision, after review, will be regarded as final.The High-Throughput-Enabling Fund can only cover part of the actual costs involved in developing andexploiting these key technologies. Substantial additional funding through additional grants of participantsand support from their institutions will be required. We estimate that actual costs will be higher by a factorof 10.288