PDF file: EURASNET Annual Report 2008

More documents

Recommendations

Info

Integration1. Young Investigator Programme (YIP)The YIP budget amounts to 1.2 M€. These funds will be distributed during two rounds of open calls for 5young investigators each. Support will be 40,000 € annually for a 3-year period. Since all the winners ofYIP awards remain to be determined, these funds can not be allocated to specific participants yet. Like thefounding members of the network, YIP members are expected to contribute at least 24 person months peryear towards EURASNET research goals.2. Interdisciplinary MeetingsFour interdisciplinary focus meetings will be organized annually around the following topics by theindicated NoE members:• Combining computational and experimental approaches to study alternative splicing (G. Ast, P.Bork)• Biophysical methods and functional genomics tools to study alternative splicing (R. Lührmann,C. Smith, I. Eperon)• Cell biology, signaling and alternative splicing (J. Cáceres, A. Lamond)• Alternative splicing and clinical research (F. Baralle, S. Stamm)Funds in the following table have been allocated accordingly.Each meeting is supported by 10,000 €, except for the meeting on splicing and disease which will receive20,000 € instead (250,000 € total over the 5-year period). Funds will provide support for travel andaccommodation of invited speakers. These meetings will have a limited number of participants (max.30) and will include both NoE members whose research is directly connected to the topic, as well asoutside experts from other fields that will be invited to participate and give a 30 minute talk about theirtechnologies or areas of expertise. These conferences also provide the opportunity to get in touch withrepresentatives of SMEs.To underscore the importance of the scientific exchange between alternative splicing researchers andclinicians, one meeting each year will be specially dedicated to this theme. This meeting will be assignedthe increased budget of 20,000 € and 50 participants will be admitted.3. Web-ServicesFundamental for integration are platforms for communication and infrastructure, particularly those that areweb-based. We plan to create web-based tools that will be both professionally useful and user-friendly,with the goal that they will become regular instruments of day-to-day research. Although the contents willbe ultimately dictated by the investigators’ needs, we aim for high caliber, highly professional web pagesthat will be created with the goal of durability and potential for expansion and review. We plan to jumpstartthese resources with the help of Network funds with the perspective that, once established, they willmaintain a durable structure that will be, at least in part, self-supported through small users’ fees.As pointed out in numerous places throughout this Annex, the EURASNET Website is one of the mostcritical points in the successful design of a European Network of Excellence as it is intended by theEuropean Commission. Therefore an amount of 550,000 € over the five year period is earmarked fordeveloping and maintaining the EURASNET Website. This site will be the hub for all Network- andPublic Science-related information traffic. Activities within this budget are organized and overseen byJohn Brown, Dundee. The amount of 550,000 € includes the webmaster employment (80,000 €/y over 5years) in Dundee, a part time position (20,000 €/y over 5 years) located at the Web-server site in Dundee,UK and additional 50,000 €/5y for necessary hardware and software.291
Joint Programme of ActivitiesINTEGRATION(60 month period)Joint Programme of ActivitiesINTEGRATION(18 month period,month 37-54, Jan '09 – June '10)1. YIPEstimated costs Requested Grant Estimated costs Requested GrantMPG 1c * 420,000 €/3y 120,000 €/3y 210,000 € 20,000 €CNRS 12d*INSERM26 *420,000 €/3y 120,000 €/3y 210,000 € 20,000 €420,000 €/3y 120,000 €/3y 210,000 € 20,000 €FCSR 27 * 420,000 €/3y 120,000 €/3y 210,000 € 20,000 €ISB-SIB 28*420,000 €/3y 120,000 €/3y 210,000 € 20,000 €* First round integrated by month 6 (July 2006). Contract ends June 2009.420,000 €/3y 120,000 €/3y 70,000 € 60,000 €ETHZ 29** 420,000 €/3y 120,000 €/3y 70,000 € 60,000 €IIMCB30**420,000 €/3y 120,000 €/3y 70,000 € 60,000 €UPF 31 ** 420,000 €/3y 120,000 €/3y 70,000 € 60,000 €FCEN-UBA20b**SOTON-HGD 32 **2 rounds of5 YIPawards420,000 €/3y 120,000 €/3y 70,000 € 60,000 €4,200,000 € 1,200,000 € 1,400,000 € 400,000 €** Second round integrated by month 25 (Jan 2008).Winners of the second round of YIP awards start their contract during the third 18month period in month 25 (Jan 2008).2. Interdisciplinary MeetingsMPG 1a 50,000x1/3 € 50,000x1/3 € 10,000x1/3 € 10,000x1/3 €UERLN 3* 100,000x1/2 € 100,000x1/2 € 20,000x1/2 € -EMBL 5a 50,000x1/2 € 50,000x1/2 € 10,000x1/2 € 10,000x1/2 €TAU 6 50,000x1/2 € 50,000x1/2 € 10,000x1/2 € 10,000x1/2 €ICGEB 7 100,000x1/2 € 100,000x1/2 € 20,000x1/2 € 20,000 €MRC 15 50,000x1/2 € 50,000x1/2 € 10,000x1/2 € 10,000x1/2 €Unileic 17 50,000x1/3 € 50,000x1/3 € 10,000x1/3 € 10,000x1/3 €UNIVDUN2250,000x1/2 € 50,000x1/2 € 10,000x1/2 € 10,000x1/2 €292
Page 3 and 4:
TABLE OF CONTENTSA. PERIODIC ACTIVI
Page 5 and 6:
1 PUBLISHABLE EXECUTIVE SUMMARY EUR
Page 7 and 8:
Dr. Davide Gabellini(28) Swiss Inst
Page 9 and 10:
WP7 Molecular characterization of s
Page 11 and 12:
To identify protein-protein interac
Page 13 and 14:
expressed in a particular tissue. T
Page 15 and 16:
Duchenne muscular dystrophy (DMD).
Page 17 and 18:
WP21 Reachout to the broader RNA co
Page 19 and 20:
4.1 TABLE OF MILESTONES JPA MONTH 2
Page 21 and 22:
Numerous plasmids, constructs, extr
Page 23 and 24:
collaboration between EURASNET and
Page 25 and 26:
5.1 WORK PACKAGE REPORTSWork Packag
Page 27 and 28:
• Ongoing regular addition of new
Page 29 and 30:
Work Package 4 The Alternative Spli
Page 31 and 32:
Work Package 6 In silico approaches
Page 33 and 34:
alternative splicing.162 Compare sp
Page 35 and 36:
33 Agreement on pre-mRNA substrates
Page 37 and 38:
its numerous binding sites on both
Page 39 and 40:
Work Package 8 Genome-wide Analyses
Page 41 and 42:
173 Further development of data ana
Page 43 and 44:
Problems and explanations for delay
Page 45 and 46:
eveal that there is a dramatic chan
Page 47 and 48:
Work Package 10 Post-translational
Page 49 and 50:
mutational analysis that led to the
Page 51 and 52:
Isolation of an active step I splic
Page 53 and 54:
FBP11 and 21 with these sequences.
Page 55 and 56:
Similarly to what observed for SF2/
Page 57 and 58:
prp45-113 mutant, which is compatib
Page 59 and 60:
cell lines. In contrast in the pres
Page 61 and 62:
genes with roles in the development
Page 63 and 64:
Structural analyses of several RRMs
Page 65:
Work Package 17 Staff Exchange and
Page 69 and 70:
Barralle's lab, Krämer is acting a
Page 71 and 72:
alternative splicing) and higher ed
Page 73 and 74:
Student Symposium “Decision Makin
Page 75 and 76:
variation and suitability for use w
Page 77 and 78:
Following feedback from members we
Page 79 and 80:
Invited seminars: In addition to me
Page 81 and 82:
Publications 2008Author Title Publi
Page 83 and 84:
Author Title Publication EURASNET P
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Minutes of the General Assembly dec
Page 96 and 97:
241 Evaluate available careerdevelo
Page 98 and 99:
156 The EURASNET memberStamm publis
Page 100 and 101:
y coarse-grained foldingsimulation.
Page 102 and 103:
overexpressor and mutant lines(mont
Page 104 and 105:
machinery with particularrespect to
Page 106 and 107:
alternative splicing, using theEDI
Page 108 and 109:
contemporary findings withinthe EUR
Page 110 and 111:
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
Page 118 and 119:
Licht K, Medenbach J, Lührmann R,K
Page 120 and 121:
Page 122 and 123:
9 TABULAR OVERVIEW OF MAJOR COST IT
Page 124 and 125:
total costs * 18.891,12 52778.60 41
Page 126 and 127:
other (the rest) 48,57 0 56.539,43t
Page 128 and 129:
travel 6.964,91overhead 3.081,07oth
Page 130 and 131:
Participant 1A Type of expenditure
Page 132 and 133:
Participant 1B - Karla Neugebauera)
Page 134 and 135:
Participant 2 - Juan Valcarcela) Wo
Page 136 and 137:
Participant 3 - Stefan Stamma) Work
Page 138 and 139:
Participant 4 - Göran Akusjärvia)
Page 140 and 141:
Participant 5A/B - Peer Bork/Rolf A
Page 142 and 143:
Major cost items• ResearchPersonn
Page 144 and 145:
Participant 7 - Francisco Barallea)
Page 146 and 147:
Francisco Baralle gave a talk to a
Page 148 and 149:
alternative splicing on human disea
Page 150 and 151:
J. Beggs has had frequent contact w
Page 152 and 153:
Page 154 and 155:
Page 156 and 157:
Participant 12A - Jamal Tazia) Work
Page 158 and 159:
Participant 12B - Bertrand Séraphi
Page 160 and 161:
Participant 12C - Christiane Branla
Page 162 and 163:
Participant 12D - Edouard Bertranda
Page 164 and 165:
Participant 13 - Daniel Schümperli
Page 166 and 167:
Participant 14 - John W. S. Browna)
Page 168 and 169:
Participant 15 - Javier F. Cáceres
Page 170 and 171:
• ResearchPersonnelName WP Person
Page 172 and 173:
MiscellaneousOligonucleotidesUse of
Page 174 and 175:
Major cost items• ResearchConsuma
Page 176 and 177:
Page 178 and 179:
Participant 21 - Angela Krämera) W
Page 180 and 181:
Participant 22 - Angus Lamonda) Wor
Page 182 and 183:
Participant 23 - Chris Smitha) Work
Page 184 and 185:
ChemicalsEnzymesLaboratory supplies
Page 186 and 187:
Participant 26 - Didier Auboeufa) W
Page 188 and 189:
tool for the molecular analysis of
Page 190 and 191:
Participant 29 - Frédéric Allaina
Page 192 and 193:
protein and instead possesses the d
Page 194 and 195:
+ overhead 4.730= total eligible co
Page 196 and 197:
Claudia Tamaro (PhD) has begun work
Page 198 and 199:
ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 200 and 201:
Direct eligible costs 53.240,48 0,0
Page 202 and 203:
Direct eligible costs 18.720,07 0,0
Page 204 and 205:
13 REPORT ON THE DISTRIBUTION OF TH
Page 206 and 207:
Report on the Distribution of the C
Page 208 and 209:
For most work packages here follows
Page 210 and 211:
pathways (eg, Reactome ).While PAND
Page 212 and 213:
The possible dependence of the effe
Page 214 and 215:
In some treatments or mutants, simi
Page 216 and 217:
Work Package 12: Mis-splicing and D
Page 218 and 219:
acid. Furthermore, using antibodies
Page 220 and 221:
At the 2007 annual meeting in Ile d
Page 222 and 223:
Partner 13 has extensively studied
Page 224 and 225:
inhibitors/modulators of RNA splici
Page 226 and 227:
18 MONTH JPA: WORKPACKAGE TIMECOURS
Page 228 and 229:
15.3 GRAPHICAL PRESENTATION OF WORK
Page 230 and 231:
15.4 TABLE OF MILESTONES (MONTH 37-
Page 232 and 233:
156 The EURASNET memberStamm publis
Page 234 and 235:
194 Bertrand will analyze indetail
Page 236 and 237:
216 Aubeouf and Neugebauer willcoll
Page 238 and 239:
238 Establishing joint PhDcommittee
Page 240 and 241:
283 A unified browser for allknown
Page 242 and 243: 296 Group 12a (Branlant) willuse th
Page 244 and 245: 315 Lamond will use a FLIM-FRET bas
Page 246 and 247: 329 GROUP 7 (F. BARALLE)will contin
Page 248 and 249: 333 GROUP 27 (GABELLINI)will:1) foc
Page 250 and 251: 345 Schümperli’s group isplannin
Page 252 and 253: 366 Quarterly network e-mail atmont
Page 254 and 255: 2. Sharing Resources, Technology an
Page 256 and 257: 5. Ensuring DurabilityWorkpackage d
Page 258 and 259: 7. Molecular Characterization of Sp
Page 260 and 261: 8. Genome-wide Analyses of Splicing
Page 262 and 263: 9. Complexity of Spliceosomal Prote
Page 264 and 265: 202 Srebrow will investigate the ro
Page 266 and 267: 12. Mis-splicing and DiseaseWorkpac
Page 268 and 269: 13. Co-transcriptional Mechanisms o
Page 270 and 271: 14. Chemical Biology and Therapeuti
Page 272 and 273: 15. Development of Enabling Technol
Page 274 and 275: 269 IFMs in 20091. “Alternative a
Page 276 and 277: 18. Career DevelopmentWorkpackage d
Page 278 and 279: 20. SMEs and Technology TransferWor
Page 280 and 281: 21. Reachout to the Broader RNA Com
Page 282 and 283: 15.7 WORK PACKAGE LIST (MONTHS 37-5
Page 284 and 285: ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 286 and 287: AMU 5 29 8 42UAAR 5 145 16 1665 29
Page 288 and 289: Joint Programme of Activities RESEA
Page 290 and 291: 60 month period 18 month periodRequ
Page 294 and 295: UCAM-DBIOC 2350,000x1/3 € 50,000x
Page 296: the management team. Audit costs ar
show all

PDF file: EURASNET Annual Report 2008

Create successful ePaper yourself

Delete template?

Save as template?