PDF file: EURASNET Annual Report 2008

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21. Reachout to the Broader RNA CommunityWorkpackage description (month 37-54)Workpackage number 21 Start date or starting event: 7 monthParticipant idallPerson months 30.5Objectives• To identify and make contact with other EU-funded groups and other relevant organizations in Europe, toproduce a database of e-mail contacts of their members.• To establish contact with these members and make them aware of our existence and our aims.• To promote exchange of expertise within this extended network.• To collect and disseminate information about conferences and workshops on relevant topics.• To identify sources of grant funding for applications to extend these activities• To identify commercial organisations to support and promote RNA researchDescription of work:The many and varied activities of the EURASNET members in promoting alternative splicing research and theNetwork will continue throughout the new JPA. The work programme for months 25-42 for WP21 will focus onefficient information gathering and quantification of these activities. In addition, the need for greater interactionwith clinicians and medical scientists involved with splicing- and alternative splicing-related diseases will beaddressed by identifying these individuals in the member countries and inviting them to attend meetings andworkshops and sending information about EURASNET.Deliverables252 Invite non-EURASNET RNA researchers to workshops/meetings to support interactions and collaborations.(month 42) (continuation of deliverable 123)253 Maintain updated contact list of RNA researchers and groups in Europe. (month 42). (continuation ofdeliverable 124)256 Regular requests for information from members. Requests for information will be sent out quarterly andcollated. (month 42)363 Maintain contacts of RNA researchers and appropriate clinicians and disseminate information on meetings,workshops and items of interest by direct contact and via the new website (month 54).364 Capture and quantify information on EURASNET activities by regular general and targeted requests (month54).279
22. ManagementWorkpackage description (month 37-54)Workpackage number 22 Start date or starting event: 0 monthParticipant id 1a 2 14 9 15 16 21 22Person months 45 13.5 13.5 0.5 0.5 0.5 0.5 0.5Objectives• Manage the research, integration and dissemination components of the NoE by the management teamDescription of workOrganize and survey network operations, manage financial operations. Provide assistance for all organizational,legal and financial problems. Organize and survey integration and dissemination activities.Deliverables258 Prepare Annual Report for 2008 period (month 38).261 Report on decisions made during the Annual Meeting 2009 (month 41).270 Prepare Annual Report for 2009 period (month 50).365 Steering Committee Meetings at month 39, 42, 45, 48, 51, 54366 Quarterly network e-mail at months 39, 42, 45, 48, 51, 54280
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TABLE OF CONTENTSA. PERIODIC ACTIVI
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1 PUBLISHABLE EXECUTIVE SUMMARY EUR
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Dr. Davide Gabellini(28) Swiss Inst
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WP7 Molecular characterization of s
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To identify protein-protein interac
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expressed in a particular tissue. T
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Duchenne muscular dystrophy (DMD).
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WP21 Reachout to the broader RNA co
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4.1 TABLE OF MILESTONES JPA MONTH 2
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Numerous plasmids, constructs, extr
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collaboration between EURASNET and
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5.1 WORK PACKAGE REPORTSWork Packag
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• Ongoing regular addition of new
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Work Package 4 The Alternative Spli
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Work Package 6 In silico approaches
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alternative splicing.162 Compare sp
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33 Agreement on pre-mRNA substrates
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its numerous binding sites on both
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Work Package 8 Genome-wide Analyses
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173 Further development of data ana
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Problems and explanations for delay
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eveal that there is a dramatic chan
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Work Package 10 Post-translational
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mutational analysis that led to the
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Isolation of an active step I splic
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FBP11 and 21 with these sequences.
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Similarly to what observed for SF2/
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prp45-113 mutant, which is compatib
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cell lines. In contrast in the pres
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genes with roles in the development
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Structural analyses of several RRMs
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Work Package 17 Staff Exchange and
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Barralle's lab, Krämer is acting a
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alternative splicing) and higher ed
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Student Symposium “Decision Makin
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variation and suitability for use w
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Following feedback from members we
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Invited seminars: In addition to me
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Publications 2008Author Title Publi
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Author Title Publication EURASNET P
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Minutes of the General Assembly dec
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241 Evaluate available careerdevelo
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156 The EURASNET memberStamm publis
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y coarse-grained foldingsimulation.
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overexpressor and mutant lines(mont
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machinery with particularrespect to
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alternative splicing, using theEDI
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contemporary findings withinthe EUR
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Licht K, Medenbach J, Lührmann R,K
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9 TABULAR OVERVIEW OF MAJOR COST IT
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total costs * 18.891,12 52778.60 41
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other (the rest) 48,57 0 56.539,43t
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travel 6.964,91overhead 3.081,07oth
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Participant 1A Type of expenditure
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Participant 1B - Karla Neugebauera)
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Participant 2 - Juan Valcarcela) Wo
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Participant 3 - Stefan Stamma) Work
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Participant 4 - Göran Akusjärvia)
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Participant 5A/B - Peer Bork/Rolf A
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Major cost items• ResearchPersonn
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Participant 7 - Francisco Barallea)
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Francisco Baralle gave a talk to a
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alternative splicing on human disea
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J. Beggs has had frequent contact w
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Participant 12A - Jamal Tazia) Work
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Participant 12B - Bertrand Séraphi
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Participant 12C - Christiane Branla
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Participant 12D - Edouard Bertranda
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Participant 13 - Daniel Schümperli
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Participant 14 - John W. S. Browna)
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Participant 15 - Javier F. Cáceres
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• ResearchPersonnelName WP Person
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MiscellaneousOligonucleotidesUse of
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Major cost items• ResearchConsuma
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Participant 21 - Angela Krämera) W
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Participant 22 - Angus Lamonda) Wor
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Participant 23 - Chris Smitha) Work
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ChemicalsEnzymesLaboratory supplies
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Participant 26 - Didier Auboeufa) W
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tool for the molecular analysis of
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Participant 29 - Frédéric Allaina
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protein and instead possesses the d
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+ overhead 4.730= total eligible co
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Claudia Tamaro (PhD) has begun work
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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Direct eligible costs 53.240,48 0,0
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Direct eligible costs 18.720,07 0,0
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13 REPORT ON THE DISTRIBUTION OF TH
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Report on the Distribution of the C
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For most work packages here follows
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pathways (eg, Reactome ).While PAND
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The possible dependence of the effe
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In some treatments or mutants, simi
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Work Package 12: Mis-splicing and D
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acid. Furthermore, using antibodies
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At the 2007 annual meeting in Ile d
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Partner 13 has extensively studied
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inhibitors/modulators of RNA splici
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18 MONTH JPA: WORKPACKAGE TIMECOURS
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15.3 GRAPHICAL PRESENTATION OF WORK
Page 230 and 231: 15.4 TABLE OF MILESTONES (MONTH 37-
Page 232 and 233: 156 The EURASNET memberStamm publis
Page 234 and 235: 194 Bertrand will analyze indetail
Page 236 and 237: 216 Aubeouf and Neugebauer willcoll
Page 238 and 239: 238 Establishing joint PhDcommittee
Page 240 and 241: 283 A unified browser for allknown
Page 242 and 243: 296 Group 12a (Branlant) willuse th
Page 244 and 245: 315 Lamond will use a FLIM-FRET bas
Page 246 and 247: 329 GROUP 7 (F. BARALLE)will contin
Page 248 and 249: 333 GROUP 27 (GABELLINI)will:1) foc
Page 250 and 251: 345 Schümperli’s group isplannin
Page 252 and 253: 366 Quarterly network e-mail atmont
Page 254 and 255: 2. Sharing Resources, Technology an
Page 256 and 257: 5. Ensuring DurabilityWorkpackage d
Page 258 and 259: 7. Molecular Characterization of Sp
Page 260 and 261: 8. Genome-wide Analyses of Splicing
Page 262 and 263: 9. Complexity of Spliceosomal Prote
Page 264 and 265: 202 Srebrow will investigate the ro
Page 266 and 267: 12. Mis-splicing and DiseaseWorkpac
Page 268 and 269: 13. Co-transcriptional Mechanisms o
Page 270 and 271: 14. Chemical Biology and Therapeuti
Page 272 and 273: 15. Development of Enabling Technol
Page 274 and 275: 269 IFMs in 20091. “Alternative a
Page 276 and 277: 18. Career DevelopmentWorkpackage d
Page 278 and 279: 20. SMEs and Technology TransferWor
Page 282 and 283: 15.7 WORK PACKAGE LIST (MONTHS 37-5
Page 284 and 285: ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 286 and 287: AMU 5 29 8 42UAAR 5 145 16 1665 29
Page 288 and 289: Joint Programme of Activities RESEA
Page 290 and 291: 60 month period 18 month periodRequ
Page 292 and 293: Integration1. Young Investigator Pr
Page 294 and 295: UCAM-DBIOC 2350,000x1/3 € 50,000x
Page 296: the management team. Audit costs ar
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