- Page 3 and 4: TABLE OF CONTENTSA. PERIODIC ACTIVI
- Page 5 and 6: 1 PUBLISHABLE EXECUTIVE SUMMARY EUR
- Page 7 and 8: Dr. Davide Gabellini(28) Swiss Inst
- Page 9 and 10: WP7 Molecular characterization of s
- Page 11 and 12: To identify protein-protein interac
- Page 13 and 14: expressed in a particular tissue. T
- Page 15 and 16: Duchenne muscular dystrophy (DMD).
- Page 17 and 18: WP21 Reachout to the broader RNA co
- Page 19 and 20: 4.1 TABLE OF MILESTONES JPA MONTH 2
- Page 21: Numerous plasmids, constructs, extr
- Page 25 and 26: 5.1 WORK PACKAGE REPORTSWork Packag
- Page 27 and 28: • Ongoing regular addition of new
- Page 29 and 30: Work Package 4 The Alternative Spli
- Page 31 and 32: Work Package 6 In silico approaches
- Page 33 and 34: alternative splicing.162 Compare sp
- Page 35 and 36: 33 Agreement on pre-mRNA substrates
- Page 37 and 38: its numerous binding sites on both
- Page 39 and 40: Work Package 8 Genome-wide Analyses
- Page 41 and 42: 173 Further development of data ana
- Page 43 and 44: Problems and explanations for delay
- Page 45 and 46: eveal that there is a dramatic chan
- Page 47 and 48: Work Package 10 Post-translational
- Page 49 and 50: mutational analysis that led to the
- Page 51 and 52: Isolation of an active step I splic
- Page 53 and 54: FBP11 and 21 with these sequences.
- Page 55 and 56: Similarly to what observed for SF2/
- Page 57 and 58: prp45-113 mutant, which is compatib
- Page 59 and 60: cell lines. In contrast in the pres
- Page 61 and 62: genes with roles in the development
- Page 63 and 64: Structural analyses of several RRMs
- Page 65: Work Package 17 Staff Exchange and
- Page 69 and 70: Barralle's lab, Krämer is acting a
- Page 71 and 72: alternative splicing) and higher ed
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Student Symposium “Decision Makin
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variation and suitability for use w
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Following feedback from members we
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Invited seminars: In addition to me
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Publications 2008Author Title Publi
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Author Title Publication EURASNET P
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Author Title Publication EURASNET P
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Author Title Publication EURASNET P
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Author Title Publication EURASNET P
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Author Title Publication EURASNET P
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Minutes of the General Assembly dec
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241 Evaluate available careerdevelo
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156 The EURASNET memberStamm publis
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y coarse-grained foldingsimulation.
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overexpressor and mutant lines(mont
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machinery with particularrespect to
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alternative splicing, using theEDI
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contemporary findings withinthe EUR
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Author Title Publication EURASNET P
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Author Title Publication EURASNET P
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Author Title Publication EURASNET P
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Author Title Publication EURASNET P
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Licht K, Medenbach J, Lührmann R,K
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Author Title Publication EURASNET P
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9 TABULAR OVERVIEW OF MAJOR COST IT
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total costs * 18.891,12 52778.60 41
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other (the rest) 48,57 0 56.539,43t
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travel 6.964,91overhead 3.081,07oth
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Participant 1A Type of expenditure
- Page 132 and 133:
Participant 1B - Karla Neugebauera)
- Page 134 and 135:
Participant 2 - Juan Valcarcela) Wo
- Page 136 and 137:
Participant 3 - Stefan Stamma) Work
- Page 138 and 139:
Participant 4 - Göran Akusjärvia)
- Page 140 and 141:
Participant 5A/B - Peer Bork/Rolf A
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Major cost items• ResearchPersonn
- Page 144 and 145:
Participant 7 - Francisco Barallea)
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Francisco Baralle gave a talk to a
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alternative splicing on human disea
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J. Beggs has had frequent contact w
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Major cost items• ResearchPersonn
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Major cost items• ResearchPersonn
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Participant 12A - Jamal Tazia) Work
- Page 158 and 159:
Participant 12B - Bertrand Séraphi
- Page 160 and 161:
Participant 12C - Christiane Branla
- Page 162 and 163:
Participant 12D - Edouard Bertranda
- Page 164 and 165:
Participant 13 - Daniel Schümperli
- Page 166 and 167:
Participant 14 - John W. S. Browna)
- Page 168 and 169:
Participant 15 - Javier F. Cáceres
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• ResearchPersonnelName WP Person
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MiscellaneousOligonucleotidesUse of
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Major cost items• ResearchConsuma
- Page 176 and 177:
Major cost items• ResearchPersonn
- Page 178 and 179:
Participant 21 - Angela Krämera) W
- Page 180 and 181:
Participant 22 - Angus Lamonda) Wor
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Participant 23 - Chris Smitha) Work
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ChemicalsEnzymesLaboratory supplies
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Participant 26 - Didier Auboeufa) W
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tool for the molecular analysis of
- Page 190 and 191:
Participant 29 - Frédéric Allaina
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protein and instead possesses the d
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+ overhead 4.730= total eligible co
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Claudia Tamaro (PhD) has begun work
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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Direct eligible costs 53.240,48 0,0
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Direct eligible costs 18.720,07 0,0
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13 REPORT ON THE DISTRIBUTION OF TH
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Report on the Distribution of the C
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For most work packages here follows
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pathways (eg, Reactome ).While PAND
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The possible dependence of the effe
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In some treatments or mutants, simi
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Work Package 12: Mis-splicing and D
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acid. Furthermore, using antibodies
- Page 220 and 221:
At the 2007 annual meeting in Ile d
- Page 222 and 223:
Partner 13 has extensively studied
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inhibitors/modulators of RNA splici
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18 MONTH JPA: WORKPACKAGE TIMECOURS
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15.3 GRAPHICAL PRESENTATION OF WORK
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15.4 TABLE OF MILESTONES (MONTH 37-
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156 The EURASNET memberStamm publis
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194 Bertrand will analyze indetail
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216 Aubeouf and Neugebauer willcoll
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238 Establishing joint PhDcommittee
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283 A unified browser for allknown
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296 Group 12a (Branlant) willuse th
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315 Lamond will use a FLIM-FRET bas
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329 GROUP 7 (F. BARALLE)will contin
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333 GROUP 27 (GABELLINI)will:1) foc
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345 Schümperli’s group isplannin
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366 Quarterly network e-mail atmont
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2. Sharing Resources, Technology an
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5. Ensuring DurabilityWorkpackage d
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7. Molecular Characterization of Sp
- Page 260 and 261:
8. Genome-wide Analyses of Splicing
- Page 262 and 263:
9. Complexity of Spliceosomal Prote
- Page 264 and 265:
202 Srebrow will investigate the ro
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12. Mis-splicing and DiseaseWorkpac
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13. Co-transcriptional Mechanisms o
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14. Chemical Biology and Therapeuti
- Page 272 and 273:
15. Development of Enabling Technol
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269 IFMs in 20091. “Alternative a
- Page 276 and 277:
18. Career DevelopmentWorkpackage d
- Page 278 and 279:
20. SMEs and Technology TransferWor
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21. Reachout to the Broader RNA Com
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15.7 WORK PACKAGE LIST (MONTHS 37-5
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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AMU 5 29 8 42UAAR 5 145 16 1665 29
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Joint Programme of Activities RESEA
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60 month period 18 month periodRequ
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Integration1. Young Investigator Pr
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UCAM-DBIOC 2350,000x1/3 € 50,000x
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the management team. Audit costs ar