PDF file: EURASNET Annual Report 2008

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Work Package 18 Career DevelopmentLead Participant: Jørgen Kjemsmonthplanned achieveddeliverables: 118 Career development related round table discussions withrepresentatives of both academia and industry (month 30).30 29119 Organization of a workshop on career development at theKrakow meeting (month29)29 29238 Establishing joint PhD committees for PhD students in theEURASNET. (month 42) (continuation of deliverable 16)42 42239 Organization of a mentor lunch (month 29) 29 29240 Organization of job interviews at the Krakow meeting(month 29)241 Evaluate available career development training courseswithin the EURASNET network for appropriateness for ourpre- and postdocs (month 36)242 Pursue the possibility of selecting one program for a 1-2day career development workshop in which participants gethands-on training in the chosen topic (eg writing the cv,giving a talk or an interview, making and presenting aposter) (month 41)29 2936 3641 41Objectives of the work package• To prepare young scientists for careers in science, teaching and industry• To facilitate the transition from a post-doctoral fellow to an independent group leader• To give young scientists the opportunity to raise the profile of their research and their research groups, and to establishlasting contacts/collaborations among the young generation of European scientistsShort description of activities118 Career development related round table discussions with representatives of both academia and industry.A round table discussion was included in the Krakow career development program (See report to D119). Many of theEURASNET members are highly active in the arrangement of career develoment workshops, both at their home universitiesand throughout the world. A particular active member is Karla Neugebauer who in 2008 gave a talk on Women in Science:Canadian RNA meeting, participated as a mentor in Robert-Bosch-Stiftung leadership training course for women inacademic biological research, and acted as the Chair of the ELSO Career Development Committee.119 Organization of a workshop on career development at the Krakow meeting.A workshop entitled "Career Paths for RNA Scientists" was included in the Krakow meeting. A total of 27 young scientistsfrom 23 EURASNET institutions, 5 speakers, and 3 EURASNET PIs participated in the workshop. The program covered awide spectrum of career related topics with representatives form industry, by Jie Kang, Head of Gene Silencing Research, atQiagen talking about "Career Paths for RNA Researchers in Industry", from the publishing industry, Associate Editor NatureStructure and Molecular Biology, Sabbi Lall, talking about "Steps along the way: RNA researchers tell their own stories",two young scientist, Frédéric Allain and Anabella Srebrow, both with recent interesting divergent career path story, andfinally Carol Featherstone, a freelance science writer and consultant, talking about "Mobility in European ScientificResearch". Each talk was all followed by a general discussion and the workshop was concluded with a round tablediscussion where all career related questions were brought up.238 Establishing joint PhD committees for PhD students in the EURASNET.There has been at least 12 registered joint PhD committees or co-supervisions established in 2008 including within theEURASENET network:J Stevenin was member of the comittee of a PhD defense in Christiane Branlant's lab, Ian Eperon and Angus Lamond havesupervised two PhD students in Baralle's lab, Chris Smith has acted recently as the external examiner for the PhD inCaceres's lab, Bindereif acted on a Ph.D. committee for a PhD student in the Lührmann lab, Bujnicki was external memberof a PhD committee in Bindereif's lab, lbrecht Bindereif served as reader and evaluator of a PhD thesis in KarlaNeugebauer's lab, Ast served on the PhD committee for a student in Soreq's lab, Kornblihtt was a member of the PhD thesiscommittee for a PhD student in Carmo-Fonseca's lab, Carmo-Fonseca has acted as the external examiner for a PhD studentin Auboeuf's lab, Brown was on a PhD committee for a student in Barta's lab, Tazi is an examiner of a PhD thesis in67
Barralle's lab, Krämer is acting as co-referee and external tutor for my PhD student in Schümperli' lab, and Eyras is part ofthe PhD committee for a student in Frédéric's lab.239 Organization of a mentor lunch.A mentor lunch with a about 50 participants was organized at the Krakow meeting. The participants where divided into 6groups of about 8 together with two volunteer mentors from the EURASNET PI network. The lunch lasted for 1 hour andwas very successful.240 Organization of job interviews at the Krakow meeting.Direct interaction between representatives from industry (Jie Kang and Sabbi Lall) and the students occurred on a aninformal basis after the workshop241 Evaluate available career development training courses within the EURASNET network for appropriateness for our preandpostdocs.A number of available programs on career development have been evaluated. It has been decided to use a preassessed 1 daycourse led by Carol Featherston.242 Pursue the possibility of selecting one program for a 1-2 day career development .The preliminary program for a career development training courses has been suggested. It will be led by Carol Featherstone.Problems and explanations for delays, postponements etc.##68
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TABLE OF CONTENTSA. PERIODIC ACTIVI
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1 PUBLISHABLE EXECUTIVE SUMMARY EUR
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Dr. Davide Gabellini(28) Swiss Inst
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WP7 Molecular characterization of s
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To identify protein-protein interac
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expressed in a particular tissue. T
Page 15 and 16: Duchenne muscular dystrophy (DMD).
Page 17 and 18: WP21 Reachout to the broader RNA co
Page 19 and 20: 4.1 TABLE OF MILESTONES JPA MONTH 2
Page 21 and 22: Numerous plasmids, constructs, extr
Page 23 and 24: collaboration between EURASNET and
Page 25 and 26: 5.1 WORK PACKAGE REPORTSWork Packag
Page 27 and 28: • Ongoing regular addition of new
Page 29 and 30: Work Package 4 The Alternative Spli
Page 31 and 32: Work Package 6 In silico approaches
Page 33 and 34: alternative splicing.162 Compare sp
Page 35 and 36: 33 Agreement on pre-mRNA substrates
Page 37 and 38: its numerous binding sites on both
Page 39 and 40: Work Package 8 Genome-wide Analyses
Page 41 and 42: 173 Further development of data ana
Page 43 and 44: Problems and explanations for delay
Page 45 and 46: eveal that there is a dramatic chan
Page 47 and 48: Work Package 10 Post-translational
Page 49 and 50: mutational analysis that led to the
Page 51 and 52: Isolation of an active step I splic
Page 53 and 54: FBP11 and 21 with these sequences.
Page 55 and 56: Similarly to what observed for SF2/
Page 57 and 58: prp45-113 mutant, which is compatib
Page 59 and 60: cell lines. In contrast in the pres
Page 61 and 62: genes with roles in the development
Page 63 and 64: Structural analyses of several RRMs
Page 65: Work Package 17 Staff Exchange and
Page 71 and 72: alternative splicing) and higher ed
Page 73 and 74: Student Symposium “Decision Makin
Page 75 and 76: variation and suitability for use w
Page 77 and 78: Following feedback from members we
Page 79 and 80: Invited seminars: In addition to me
Page 81 and 82: Publications 2008Author Title Publi
Page 83 and 84: Author Title Publication EURASNET P
Page 93 and 94: Minutes of the General Assembly dec
Page 96 and 97: 241 Evaluate available careerdevelo
Page 98 and 99: 156 The EURASNET memberStamm publis
Page 100 and 101: y coarse-grained foldingsimulation.
Page 102 and 103: overexpressor and mutant lines(mont
Page 104 and 105: machinery with particularrespect to
Page 106 and 107: alternative splicing, using theEDI
Page 108 and 109: contemporary findings withinthe EUR
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Author Title Publication EURASNET P
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Licht K, Medenbach J, Lührmann R,K
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Author Title Publication EURASNET P
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9 TABULAR OVERVIEW OF MAJOR COST IT
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total costs * 18.891,12 52778.60 41
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other (the rest) 48,57 0 56.539,43t
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travel 6.964,91overhead 3.081,07oth
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Participant 1A Type of expenditure
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Participant 1B - Karla Neugebauera)
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Participant 2 - Juan Valcarcela) Wo
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Participant 3 - Stefan Stamma) Work
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Participant 4 - Göran Akusjärvia)
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Participant 5A/B - Peer Bork/Rolf A
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Major cost items• ResearchPersonn
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Participant 7 - Francisco Barallea)
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Francisco Baralle gave a talk to a
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alternative splicing on human disea
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J. Beggs has had frequent contact w
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Page 154 and 155:
Page 156 and 157:
Participant 12A - Jamal Tazia) Work
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Participant 12B - Bertrand Séraphi
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Participant 12C - Christiane Branla
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Participant 12D - Edouard Bertranda
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Participant 13 - Daniel Schümperli
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Participant 14 - John W. S. Browna)
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Participant 15 - Javier F. Cáceres
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• ResearchPersonnelName WP Person
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MiscellaneousOligonucleotidesUse of
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Major cost items• ResearchConsuma
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Page 178 and 179:
Participant 21 - Angela Krämera) W
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Participant 22 - Angus Lamonda) Wor
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Participant 23 - Chris Smitha) Work
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ChemicalsEnzymesLaboratory supplies
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Participant 26 - Didier Auboeufa) W
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tool for the molecular analysis of
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Participant 29 - Frédéric Allaina
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protein and instead possesses the d
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+ overhead 4.730= total eligible co
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Claudia Tamaro (PhD) has begun work
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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Direct eligible costs 53.240,48 0,0
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Direct eligible costs 18.720,07 0,0
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13 REPORT ON THE DISTRIBUTION OF TH
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Report on the Distribution of the C
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For most work packages here follows
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pathways (eg, Reactome ).While PAND
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The possible dependence of the effe
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In some treatments or mutants, simi
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Work Package 12: Mis-splicing and D
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acid. Furthermore, using antibodies
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At the 2007 annual meeting in Ile d
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Partner 13 has extensively studied
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inhibitors/modulators of RNA splici
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18 MONTH JPA: WORKPACKAGE TIMECOURS
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15.3 GRAPHICAL PRESENTATION OF WORK
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15.4 TABLE OF MILESTONES (MONTH 37-
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156 The EURASNET memberStamm publis
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194 Bertrand will analyze indetail
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216 Aubeouf and Neugebauer willcoll
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238 Establishing joint PhDcommittee
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283 A unified browser for allknown
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296 Group 12a (Branlant) willuse th
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315 Lamond will use a FLIM-FRET bas
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329 GROUP 7 (F. BARALLE)will contin
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333 GROUP 27 (GABELLINI)will:1) foc
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345 Schümperli’s group isplannin
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366 Quarterly network e-mail atmont
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2. Sharing Resources, Technology an
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5. Ensuring DurabilityWorkpackage d
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7. Molecular Characterization of Sp
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8. Genome-wide Analyses of Splicing
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9. Complexity of Spliceosomal Prote
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202 Srebrow will investigate the ro
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12. Mis-splicing and DiseaseWorkpac
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13. Co-transcriptional Mechanisms o
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14. Chemical Biology and Therapeuti
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15. Development of Enabling Technol
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269 IFMs in 20091. “Alternative a
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18. Career DevelopmentWorkpackage d
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20. SMEs and Technology TransferWor
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21. Reachout to the Broader RNA Com
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15.7 WORK PACKAGE LIST (MONTHS 37-5
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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AMU 5 29 8 42UAAR 5 145 16 1665 29
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Joint Programme of Activities RESEA
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60 month period 18 month periodRequ
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Integration1. Young Investigator Pr
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UCAM-DBIOC 2350,000x1/3 € 50,000x
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the management team. Audit costs ar
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