PDF file: EURASNET Annual Report 2008

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15.7 WORK PACKAGE LIST (MONTHS 37-54)WPNoWorkpackage titleLeadParticipantPersonmonthsStartmonthEndmonthDeliverableNo1 The <strong>EURASNET</strong> Web site 14 8.5 37 54 149-150,273-2762 Sharing resources, technology andreliable protocols14 60 37 54 2634 The Alternative Splicing Database 5b 21 37 54 155-156,2775 Ensuring durability 16 14 37 54 278-2796 In silico approaches to alternativesplicing7 Molecular characterization of splicingsubstrates6 80 37 54 160,162-163,280-28312c 100 37 54 284-2998 Genome-wide analyses of splicingregulation23 180 37 54 176,180,184-185,262,264-266,271,300-304,9 Complexity of spliceosomal proteomes 1a 98 37 54 190-191,305-31210 Post-translational modification andintracellular dynamics of splicingfactors15 120 37 54 90,194,198-200,202,313-32111 Function of splicing factor isoforms 2 100 37 54 204-206,208,322-32812 Mis-splicing and disease 7 126 37 54 211,267,329-33313 Co-transcriptional mechanisms ofalternative splicing1b 125 37 54 215-216,219,334-34114 Chemical biology and therapeutics 12a 128 37 54 220-225,342-34815 Development of enabling technologies 12b 92 37 54 229-232,349-35016 Conferences and meetings 9 11 37 54 235,268-269,27217 Staff exchange and training 21 28.5 37 54 35118 Career development 19 27 37 54 242,238,352-35419 Public understanding of RNA biology 8 5.5 37 54 243,245-246,355-35820 SMEs and technology transfer 22 9.5 37 54 249-251,359-36221 Reachout to the broader RNAcommunity14 30.5 37 54 252-253,256,363-36422 Management 1a 74.5 37 54 258,261,270, 365-366281
15.8 PMs FOR THE 4th 18 MONTH PERIOD (MONTH 37 to 54)MPG1aMPG1bMPG1cCRGUUEMBL5aEMBL5bTAUICGEBMUWUEDINCNR 10aCNR 10bLUGCNRS 12aCNRS 12bCNRS 12cCNRS 12dUNIBESCRIMRCIMMUnileicAMUUAARFCEN-UBA20aFCEN-UBA20bUNIGEUNIVDUNUCAM-DBIOCHUJICERBM-GIEINSERMFCSRISB-SIBJoint Programme of ActivitiesIntegrating activities 1WP1 8.5WP2 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5WP4 1.5 2 8 3 1.5 1.5 1.5 1.5WP5 1.5 1.5 1.5 9.5Jointly executed research activities 3WP6 8 44 8WP7 8 10 8 8 42 8 8WP8 10 8 12 9 8 8 8 8 9 8 8 8 8 45 8 6 9WP9 39 8 8 9 8 10 8 8WP10 12 8 8 10 6 44 8 10 8 6WP11 10 42 8 8 8 8 8 8WP12 8 42 8 8 8 6 8 8 8 8 6WP13 42 8 10 9 8 10 8 8 8 8 6WP14 10 8 45 8 19 16 10 8WP15 12 6 11 8 45 10Spreading of Excellence activities 3WP16 1.5 1 0.5 0.5 0.5 4.5 0.5 0.5 0.5 0.5WP17 1.5 1.5 0.5 1 1 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 1 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 5.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5WP18 1.5 1.5 1 1 1 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 5.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 1 1 0.5WP19 0.5 4 0.5 0.5WP20 1.5 1 0.5 0.5 0.5 0.5 0.5 4 0.5WP21 1.5 1.5 1 1 1 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 1 0.5 5.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 1 1 0.5TOTALJPA96 59.5 63 44.5 13.5 19 68.5 57.5 16.5 37 43 35.5 19.5 77.5 65 27.5 19.5 22.5 62.5 37 62 11.5 46.5 11 11 24.5 32.5 63 19.5 19Consortium Management ActivitiesWP22Management45 13.5 0.5 13.5 0.5 0.5 0.5 0.5TOTALperparticipant145 59.5 10 77.5 44.5 13.5 19 74 57.5 16.5 38 43 35.5 19.5 82.5 68 27.5 10 22.5 47.5 66 39 62 11.5 48 11 13 26.5 37 66 19.5 19 22 10 21.5Overalltotalefforts(all numbers refer to person months)2821 except management of the consortium activities
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TABLE OF CONTENTSA. PERIODIC ACTIVI
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1 PUBLISHABLE EXECUTIVE SUMMARY EUR
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Dr. Davide Gabellini(28) Swiss Inst
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WP7 Molecular characterization of s
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To identify protein-protein interac
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expressed in a particular tissue. T
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Duchenne muscular dystrophy (DMD).
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WP21 Reachout to the broader RNA co
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4.1 TABLE OF MILESTONES JPA MONTH 2
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Numerous plasmids, constructs, extr
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collaboration between EURASNET and
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5.1 WORK PACKAGE REPORTSWork Packag
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• Ongoing regular addition of new
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Work Package 4 The Alternative Spli
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Work Package 6 In silico approaches
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alternative splicing.162 Compare sp
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33 Agreement on pre-mRNA substrates
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its numerous binding sites on both
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Work Package 8 Genome-wide Analyses
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173 Further development of data ana
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Problems and explanations for delay
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eveal that there is a dramatic chan
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Work Package 10 Post-translational
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mutational analysis that led to the
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Isolation of an active step I splic
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FBP11 and 21 with these sequences.
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Similarly to what observed for SF2/
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prp45-113 mutant, which is compatib
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cell lines. In contrast in the pres
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genes with roles in the development
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Structural analyses of several RRMs
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Work Package 17 Staff Exchange and
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Barralle's lab, Krämer is acting a
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alternative splicing) and higher ed
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Student Symposium “Decision Makin
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variation and suitability for use w
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Following feedback from members we
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Invited seminars: In addition to me
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Publications 2008Author Title Publi
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Author Title Publication EURASNET P
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Minutes of the General Assembly dec
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241 Evaluate available careerdevelo
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156 The EURASNET memberStamm publis
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y coarse-grained foldingsimulation.
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overexpressor and mutant lines(mont
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machinery with particularrespect to
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alternative splicing, using theEDI
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contemporary findings withinthe EUR
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Licht K, Medenbach J, Lührmann R,K
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9 TABULAR OVERVIEW OF MAJOR COST IT
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total costs * 18.891,12 52778.60 41
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other (the rest) 48,57 0 56.539,43t
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travel 6.964,91overhead 3.081,07oth
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Participant 1A Type of expenditure
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Participant 1B - Karla Neugebauera)
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Participant 2 - Juan Valcarcela) Wo
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Participant 3 - Stefan Stamma) Work
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Participant 4 - Göran Akusjärvia)
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Participant 5A/B - Peer Bork/Rolf A
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Major cost items• ResearchPersonn
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Participant 7 - Francisco Barallea)
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Francisco Baralle gave a talk to a
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alternative splicing on human disea
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J. Beggs has had frequent contact w
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Participant 12A - Jamal Tazia) Work
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Participant 12B - Bertrand Séraphi
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Participant 12C - Christiane Branla
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Participant 12D - Edouard Bertranda
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Participant 13 - Daniel Schümperli
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Participant 14 - John W. S. Browna)
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Participant 15 - Javier F. Cáceres
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• ResearchPersonnelName WP Person
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MiscellaneousOligonucleotidesUse of
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Major cost items• ResearchConsuma
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Participant 21 - Angela Krämera) W
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Participant 22 - Angus Lamonda) Wor
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Participant 23 - Chris Smitha) Work
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ChemicalsEnzymesLaboratory supplies
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Participant 26 - Didier Auboeufa) W
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tool for the molecular analysis of
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Participant 29 - Frédéric Allaina
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protein and instead possesses the d
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+ overhead 4.730= total eligible co
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Claudia Tamaro (PhD) has begun work
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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Direct eligible costs 53.240,48 0,0
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Direct eligible costs 18.720,07 0,0
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13 REPORT ON THE DISTRIBUTION OF TH
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Report on the Distribution of the C
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For most work packages here follows
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pathways (eg, Reactome ).While PAND
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The possible dependence of the effe
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In some treatments or mutants, simi
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Work Package 12: Mis-splicing and D
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acid. Furthermore, using antibodies
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At the 2007 annual meeting in Ile d
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Partner 13 has extensively studied
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inhibitors/modulators of RNA splici
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18 MONTH JPA: WORKPACKAGE TIMECOURS
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15.3 GRAPHICAL PRESENTATION OF WORK
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15.4 TABLE OF MILESTONES (MONTH 37-
Page 232 and 233: 156 The EURASNET memberStamm publis
Page 234 and 235: 194 Bertrand will analyze indetail
Page 236 and 237: 216 Aubeouf and Neugebauer willcoll
Page 238 and 239: 238 Establishing joint PhDcommittee
Page 240 and 241: 283 A unified browser for allknown
Page 242 and 243: 296 Group 12a (Branlant) willuse th
Page 244 and 245: 315 Lamond will use a FLIM-FRET bas
Page 246 and 247: 329 GROUP 7 (F. BARALLE)will contin
Page 248 and 249: 333 GROUP 27 (GABELLINI)will:1) foc
Page 250 and 251: 345 Schümperli’s group isplannin
Page 252 and 253: 366 Quarterly network e-mail atmont
Page 254 and 255: 2. Sharing Resources, Technology an
Page 256 and 257: 5. Ensuring DurabilityWorkpackage d
Page 258 and 259: 7. Molecular Characterization of Sp
Page 260 and 261: 8. Genome-wide Analyses of Splicing
Page 262 and 263: 9. Complexity of Spliceosomal Prote
Page 264 and 265: 202 Srebrow will investigate the ro
Page 266 and 267: 12. Mis-splicing and DiseaseWorkpac
Page 268 and 269: 13. Co-transcriptional Mechanisms o
Page 270 and 271: 14. Chemical Biology and Therapeuti
Page 272 and 273: 15. Development of Enabling Technol
Page 274 and 275: 269 IFMs in 20091. “Alternative a
Page 276 and 277: 18. Career DevelopmentWorkpackage d
Page 278 and 279: 20. SMEs and Technology TransferWor
Page 280 and 281: 21. Reachout to the Broader RNA Com
Page 284 and 285: ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 286 and 287: AMU 5 29 8 42UAAR 5 145 16 1665 29
Page 288 and 289: Joint Programme of Activities RESEA
Page 290 and 291: 60 month period 18 month periodRequ
Page 292 and 293: Integration1. Young Investigator Pr
Page 294 and 295: UCAM-DBIOC 2350,000x1/3 € 50,000x
Page 296: the management team. Audit costs ar
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