PDF file: EURASNET Annual Report 2008

Participant 19 – Jørgen Kjemsa) Work performed during the period• WP2UAAR has provided lab protocols• WP7UAAR has identified hnRNP H as a regulator of alternative splicing of HIV-1 and MCAD• WP8UAAR has characterized some binding sites for HIV-1 Rev in cellular mRNA that were isolated bygenomic SELEX in terms Rev affinity and potential co-regulation during HIV-1 infection• WP9UAAR has validated some of the proteins characterized by mass spec analysis to bind differentially towild type and mutated MCAD.• WP12UAAR has tried to optimize the design of chemically modified oligonucleotides for more efficientexon 5 inclusion in MCAD missplicing.• WP13UAAR has found the splicing factor SF2 stimulates transcription of the HIV-1 genome througha mechanism that involves U1 recruitment to the proximal splice site.• WP17UAAR has not had any student exchanges in this period.• WP18UAAR has arranged and activity taken part in a workshop on career development, round tablediscussions, job interviews and mentor lunch at the Krakow meeting Career development. UAAR hasalso organized text and material for URASNET career web site.b) Major cost items with justificationParticipant 1A Type of expenditure Budget total costspersonnel EUR 35.999,21consumables EUR 4.274,46trainingequipmenttravel EUR 3.032,23= total direct costs EUR 43.305,90+ overhead EUR 8.661,18= total eligible costs EUR 51.967,08174