PDF file: EURASNET Annual Report 2008

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AMU 5 29 8 42UAAR 5 145 16 1665 29 6 403 16 3 22UNIGE 11 58 18 2 89UNIVDUN 11 92 16 2 12111 203 44 258HUJI 5 58 8 715 58 6 69INSERM 3 52 10 65FCSR 3 17 10 30ISB-SIB 7 35 10 52ETHZ 3 16 3 22IIMCB 3 16 3 22UPF 3 16 5 24FCEN-UBA 20aFCEN-UBA 20bUCAM-DBIOCCERBM-GIESOTON-HGD4 24 5 33Total peractivitytype397 3807 361 250Overalltotal effort4831(all numbers refer to person months; full duration for YIP contractors is 3year)285
16 Project management level description of resources and grant grant [month 37-54; Jan 2009-June 2010]The EURASNET consortium has been granted a maximum of 10 million Euros from the EU. This isestimated to be not more than 30% of expected expenditure required to carry out the activities specified inthe JPA of this proposal. We have included a headcount of 147 researchers, which is in excess of 100researchers required for a requested grant of 10 million euros. We also have 80 doctoral students, all ofwhich justifies a contribution from the EU of the amount granted.The content and scope of the EURASNET JPA represent a very substantial effort that will requireconsiderable human, material and financial resources. The network consortium since 2008 implicates 40laboratories and over 150 investigators. This equates to an equivalent of more than 10,000 person monthsmanpower capacity. At current rates, the estimated manpower cost for this effort represents over 25 MEUR in stipends alone. We estimate that the actual cost of the research itself in terms of reagents, etc. willbe in the range of 25-40 M EUR for the five years period again, at current prices. The EU funds granted tosupport JPA research are therefore considerably lower than the actual costs of the planned research.Importantly, these estimates do not consider equipment acquisition or maintenance, a particularly relevantconsideration taking into account the heavy component of development and use of new technologiesoutlined in the application. It is also important to point out that the JPA-related research is just part of theactivities –in fact largely a newly conceived activity- of the research being carried out by the Network,whose overall budget would easily triplicate these figures.The EURASNET NoE uses 10 M€ to support the Joint Programmes of Activities of the consortium inresearch, integration and dissemination, as well as the overall network management (see Fig. 7). 6.05 M€are assigned to research activities. This includes the annual allocation for each participant as well as theHigh-Throughput-Enabling Fund. The Integration Programme, supported with 2 M€, comprises the YIPProgramme, the interdisciplinary meetings and the web-services. The Dissemination Programme includesthe meetings and workshops and public science activities and receives 1.25 M€. Management is supportedwith 0.7 M€.Below, we give a detailed account of NoE-dedicated resources which the participants have available inorder to execute the Joint Program of Activities.Joint Research1. Annual AllocationIt is partly because the requested budget represents only a fraction of the real research costs, that theNetwork members decided to have a flat distribution of the research budget among the individuallaboratories, which corresponds to 40,000 EUR per laboratory per year during the first three years and30,000 EUR/year during the fourth and fifth year. This amount will cover a larger fraction of the costs forsmaller groups, whose workload will also be generally less extensive. This arrangement has been deemedfair by Network even though smaller research groups will benefit relatively more from the amountreceived.The cost to employ a postdoc vary considerably among European countries. If we assume an averageannual cost of 50,000 € and if we assume that each network partner will have at least two personsdedicated full time to Network research efforts (24 person months), then it becomes very clear that theallocated research funds alone are insufficient to support the research goals of the Network. The estimatedcosts will be three to four times higher than the requested funds. It will be left to the team leadersdiscretion on what the annual research fund would best be spend in his or her group. No additional fundsbeyond the 40,000 € (30,000 € in fourth and fifth year) will be available for consumables and equipment.286
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TABLE OF CONTENTSA. PERIODIC ACTIVI
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1 PUBLISHABLE EXECUTIVE SUMMARY EUR
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Dr. Davide Gabellini(28) Swiss Inst
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WP7 Molecular characterization of s
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To identify protein-protein interac
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expressed in a particular tissue. T
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Duchenne muscular dystrophy (DMD).
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WP21 Reachout to the broader RNA co
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4.1 TABLE OF MILESTONES JPA MONTH 2
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Numerous plasmids, constructs, extr
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collaboration between EURASNET and
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5.1 WORK PACKAGE REPORTSWork Packag
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• Ongoing regular addition of new
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Work Package 4 The Alternative Spli
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Work Package 6 In silico approaches
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alternative splicing.162 Compare sp
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33 Agreement on pre-mRNA substrates
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its numerous binding sites on both
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Work Package 8 Genome-wide Analyses
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173 Further development of data ana
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Problems and explanations for delay
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eveal that there is a dramatic chan
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Work Package 10 Post-translational
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mutational analysis that led to the
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Isolation of an active step I splic
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FBP11 and 21 with these sequences.
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Similarly to what observed for SF2/
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prp45-113 mutant, which is compatib
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cell lines. In contrast in the pres
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genes with roles in the development
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Structural analyses of several RRMs
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Work Package 17 Staff Exchange and
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Barralle's lab, Krämer is acting a
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alternative splicing) and higher ed
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Student Symposium “Decision Makin
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variation and suitability for use w
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Following feedback from members we
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Invited seminars: In addition to me
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Publications 2008Author Title Publi
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Author Title Publication EURASNET P
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Minutes of the General Assembly dec
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241 Evaluate available careerdevelo
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156 The EURASNET memberStamm publis
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y coarse-grained foldingsimulation.
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overexpressor and mutant lines(mont
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machinery with particularrespect to
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alternative splicing, using theEDI
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contemporary findings withinthe EUR
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Licht K, Medenbach J, Lührmann R,K
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9 TABULAR OVERVIEW OF MAJOR COST IT
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total costs * 18.891,12 52778.60 41
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other (the rest) 48,57 0 56.539,43t
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travel 6.964,91overhead 3.081,07oth
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Participant 1A Type of expenditure
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Participant 1B - Karla Neugebauera)
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Participant 2 - Juan Valcarcela) Wo
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Participant 3 - Stefan Stamma) Work
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Participant 4 - Göran Akusjärvia)
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Participant 5A/B - Peer Bork/Rolf A
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Major cost items• ResearchPersonn
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Participant 7 - Francisco Barallea)
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Francisco Baralle gave a talk to a
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alternative splicing on human disea
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J. Beggs has had frequent contact w
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Participant 12A - Jamal Tazia) Work
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Participant 12B - Bertrand Séraphi
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Participant 12C - Christiane Branla
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Participant 12D - Edouard Bertranda
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Participant 13 - Daniel Schümperli
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Participant 14 - John W. S. Browna)
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Participant 15 - Javier F. Cáceres
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• ResearchPersonnelName WP Person
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MiscellaneousOligonucleotidesUse of
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Major cost items• ResearchConsuma
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Participant 21 - Angela Krämera) W
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Participant 22 - Angus Lamonda) Wor
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Participant 23 - Chris Smitha) Work
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ChemicalsEnzymesLaboratory supplies
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Participant 26 - Didier Auboeufa) W
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tool for the molecular analysis of
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Participant 29 - Frédéric Allaina
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protein and instead possesses the d
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+ overhead 4.730= total eligible co
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Claudia Tamaro (PhD) has begun work
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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Direct eligible costs 53.240,48 0,0
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Direct eligible costs 18.720,07 0,0
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13 REPORT ON THE DISTRIBUTION OF TH
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Report on the Distribution of the C
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For most work packages here follows
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pathways (eg, Reactome ).While PAND
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The possible dependence of the effe
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In some treatments or mutants, simi
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Work Package 12: Mis-splicing and D
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acid. Furthermore, using antibodies
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At the 2007 annual meeting in Ile d
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Partner 13 has extensively studied
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inhibitors/modulators of RNA splici
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18 MONTH JPA: WORKPACKAGE TIMECOURS
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15.3 GRAPHICAL PRESENTATION OF WORK
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15.4 TABLE OF MILESTONES (MONTH 37-
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156 The EURASNET memberStamm publis
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194 Bertrand will analyze indetail
Page 236 and 237: 216 Aubeouf and Neugebauer willcoll
Page 238 and 239: 238 Establishing joint PhDcommittee
Page 240 and 241: 283 A unified browser for allknown
Page 242 and 243: 296 Group 12a (Branlant) willuse th
Page 244 and 245: 315 Lamond will use a FLIM-FRET bas
Page 246 and 247: 329 GROUP 7 (F. BARALLE)will contin
Page 248 and 249: 333 GROUP 27 (GABELLINI)will:1) foc
Page 250 and 251: 345 Schümperli’s group isplannin
Page 252 and 253: 366 Quarterly network e-mail atmont
Page 254 and 255: 2. Sharing Resources, Technology an
Page 256 and 257: 5. Ensuring DurabilityWorkpackage d
Page 258 and 259: 7. Molecular Characterization of Sp
Page 260 and 261: 8. Genome-wide Analyses of Splicing
Page 262 and 263: 9. Complexity of Spliceosomal Prote
Page 264 and 265: 202 Srebrow will investigate the ro
Page 266 and 267: 12. Mis-splicing and DiseaseWorkpac
Page 268 and 269: 13. Co-transcriptional Mechanisms o
Page 270 and 271: 14. Chemical Biology and Therapeuti
Page 272 and 273: 15. Development of Enabling Technol
Page 274 and 275: 269 IFMs in 20091. “Alternative a
Page 276 and 277: 18. Career DevelopmentWorkpackage d
Page 278 and 279: 20. SMEs and Technology TransferWor
Page 280 and 281: 21. Reachout to the Broader RNA Com
Page 282 and 283: 15.7 WORK PACKAGE LIST (MONTHS 37-5
Page 284 and 285: ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 288 and 289: Joint Programme of Activities RESEA
Page 290 and 291: 60 month period 18 month periodRequ
Page 292 and 293: Integration1. Young Investigator Pr
Page 294 and 295: UCAM-DBIOC 2350,000x1/3 € 50,000x
Page 296: the management team. Audit costs ar
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