PDF file: EURASNET Annual Report 2008

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Major decisions executed in swift time related to meetings, workshops and fundingfor high-throughput enabling technologies.• Attendance of board meetingsSix of seven board members attended Annual meeting in Krakow.• Smooth and timely flow of resources according to budgetEC payment for 2007 was received 2008 and was immediately distributed. 2008payment was received Dec 31, 2008 and could be distributed only in January 2009.• Steering committee meeting minuteson file• Timely reporting to the ECAnnual Report 2008 submission was delayed, primarily due to slow processing offinancial report forms within members' financial departments.23
5.1 WORK PACKAGE REPORTSWork Package 1 The EURASNET Web siteLead Participant: John Brownmonthplanned achieveddeliverables: 146 Reorganization and re-siting of website (month 36) 36 30147 Design of new website with new functionality and transferof information (month 36)36 36148 Database of substances that change alternative splicing(month 36)36 36149 Liaise with targeted audiences and prepare appropriatecontent (month 42)42 Ongoing150 Tools and resources repository updated (month 42). 42 OngoingObjectives of the work package• To establish, curate and maintain a EURASNET website as a tool to promote European research on alternative splicing byconcentrating all available information, facilitating the exchange of information between NoE members and bydisseminating the activities of the NoE to the wider scientific community and public interest groupsShort description of activities146 Reorganization and re-siting of website.Hosting of website moved to SCRI; new website designed and launched; initial problems addressed. Web team recruited andstrong links with WP19 established.147 Design of new website with new functionality and transfer of information.The new website was designed to allow targeting of specific audiences (scientists, general public, clinicians and educational)and content prepared appropriately for these groups. The web team is in regular contact with EURASNET scientists forinformation gathering allowing efficient posting of news, highlights, meetings etc. Transfer of selected information from theoriginal website has been accomplished. The web team are very active in posting information on EURASNET meetings andworkshops rapidly on the website, preparing regular news items and requesting information from members.148 Database of substances that change alternative splicing.A list of chemicals which alter alternative splice site selection has been posted with relevant publications.149 Liaise with targeted audiences and prepare appropriate content.The web team continue to liaise with appropriate EURASNET members (e.g those involved in studying particular diseases,clinicians and those involved in gene therapy) to design content for specific groups. A great deal of new content (e.g.alternative splicing and disease; gene therapy approaches) has been prepared.150 Tools and resources repository updated.The members-only area is being overhauled and the content in terms of tools and resources is being revamped.ReportIn the 2007 Review Report, Philip Avner pointed out the need for the EURASNET website to better reflect the“dynamicism and quality of the NoE”. In months 25-36, the website has been significantly improved.Towards the end of 2007 the management, hosting and running of the EURASNET website (WP1) moved toGroup 14 (Brown) following the move of the Stamm Group to the USA. At the same time, the strategic decisionwas made to forge much closer interactions between WP1 and the other Dissemination WPs (WP19 “PublicUnderstanding of Science” and WP21 “Reachout to the Broader RNA Community”) as the website is the centralplatform for dissemination of information about EURASNET and alternative splicing. The three WPs weretherefore managed by Group 14 (Brown) and Group 11 (Barta) and implemented more efficiently through24
Page 3 and 4: TABLE OF CONTENTSA. PERIODIC ACTIVI
Page 5 and 6: 1 PUBLISHABLE EXECUTIVE SUMMARY EUR
Page 7 and 8: Dr. Davide Gabellini(28) Swiss Inst
Page 9 and 10: WP7 Molecular characterization of s
Page 11 and 12: To identify protein-protein interac
Page 13 and 14: expressed in a particular tissue. T
Page 15 and 16: Duchenne muscular dystrophy (DMD).
Page 17 and 18: WP21 Reachout to the broader RNA co
Page 19 and 20: 4.1 TABLE OF MILESTONES JPA MONTH 2
Page 21 and 22: Numerous plasmids, constructs, extr
Page 23: collaboration between EURASNET and
Page 27 and 28: • Ongoing regular addition of new
Page 29 and 30: Work Package 4 The Alternative Spli
Page 31 and 32: Work Package 6 In silico approaches
Page 33 and 34: alternative splicing.162 Compare sp
Page 35 and 36: 33 Agreement on pre-mRNA substrates
Page 37 and 38: its numerous binding sites on both
Page 39 and 40: Work Package 8 Genome-wide Analyses
Page 41 and 42: 173 Further development of data ana
Page 43 and 44: Problems and explanations for delay
Page 45 and 46: eveal that there is a dramatic chan
Page 47 and 48: Work Package 10 Post-translational
Page 49 and 50: mutational analysis that led to the
Page 51 and 52: Isolation of an active step I splic
Page 53 and 54: FBP11 and 21 with these sequences.
Page 55 and 56: Similarly to what observed for SF2/
Page 57 and 58: prp45-113 mutant, which is compatib
Page 59 and 60: cell lines. In contrast in the pres
Page 61 and 62: genes with roles in the development
Page 63 and 64: Structural analyses of several RRMs
Page 65: Work Package 17 Staff Exchange and
Page 69 and 70: Barralle's lab, Krämer is acting a
Page 71 and 72: alternative splicing) and higher ed
Page 73 and 74: Student Symposium “Decision Makin
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variation and suitability for use w
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Following feedback from members we
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Invited seminars: In addition to me
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Publications 2008Author Title Publi
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Author Title Publication EURASNET P
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Page 89 and 90:
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Minutes of the General Assembly dec
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241 Evaluate available careerdevelo
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156 The EURASNET memberStamm publis
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y coarse-grained foldingsimulation.
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overexpressor and mutant lines(mont
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machinery with particularrespect to
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alternative splicing, using theEDI
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contemporary findings withinthe EUR
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Licht K, Medenbach J, Lührmann R,K
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9 TABULAR OVERVIEW OF MAJOR COST IT
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total costs * 18.891,12 52778.60 41
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other (the rest) 48,57 0 56.539,43t
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travel 6.964,91overhead 3.081,07oth
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Participant 1A Type of expenditure
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Participant 1B - Karla Neugebauera)
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Participant 2 - Juan Valcarcela) Wo
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Participant 3 - Stefan Stamma) Work
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Participant 4 - Göran Akusjärvia)
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Participant 5A/B - Peer Bork/Rolf A
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Major cost items• ResearchPersonn
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Participant 7 - Francisco Barallea)
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Francisco Baralle gave a talk to a
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alternative splicing on human disea
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J. Beggs has had frequent contact w
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Page 154 and 155:
Page 156 and 157:
Participant 12A - Jamal Tazia) Work
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Participant 12B - Bertrand Séraphi
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Participant 12C - Christiane Branla
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Participant 12D - Edouard Bertranda
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Participant 13 - Daniel Schümperli
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Participant 14 - John W. S. Browna)
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Participant 15 - Javier F. Cáceres
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• ResearchPersonnelName WP Person
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MiscellaneousOligonucleotidesUse of
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Major cost items• ResearchConsuma
Page 176 and 177:
Page 178 and 179:
Participant 21 - Angela Krämera) W
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Participant 22 - Angus Lamonda) Wor
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Participant 23 - Chris Smitha) Work
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ChemicalsEnzymesLaboratory supplies
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Participant 26 - Didier Auboeufa) W
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tool for the molecular analysis of
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Participant 29 - Frédéric Allaina
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protein and instead possesses the d
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+ overhead 4.730= total eligible co
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Claudia Tamaro (PhD) has begun work
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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Direct eligible costs 53.240,48 0,0
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Direct eligible costs 18.720,07 0,0
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13 REPORT ON THE DISTRIBUTION OF TH
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Report on the Distribution of the C
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For most work packages here follows
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pathways (eg, Reactome ).While PAND
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The possible dependence of the effe
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In some treatments or mutants, simi
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Work Package 12: Mis-splicing and D
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acid. Furthermore, using antibodies
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At the 2007 annual meeting in Ile d
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Partner 13 has extensively studied
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inhibitors/modulators of RNA splici
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18 MONTH JPA: WORKPACKAGE TIMECOURS
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15.3 GRAPHICAL PRESENTATION OF WORK
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15.4 TABLE OF MILESTONES (MONTH 37-
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156 The EURASNET memberStamm publis
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194 Bertrand will analyze indetail
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216 Aubeouf and Neugebauer willcoll
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238 Establishing joint PhDcommittee
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283 A unified browser for allknown
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296 Group 12a (Branlant) willuse th
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315 Lamond will use a FLIM-FRET bas
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329 GROUP 7 (F. BARALLE)will contin
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333 GROUP 27 (GABELLINI)will:1) foc
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345 Schümperli’s group isplannin
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366 Quarterly network e-mail atmont
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2. Sharing Resources, Technology an
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5. Ensuring DurabilityWorkpackage d
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7. Molecular Characterization of Sp
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8. Genome-wide Analyses of Splicing
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9. Complexity of Spliceosomal Prote
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202 Srebrow will investigate the ro
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12. Mis-splicing and DiseaseWorkpac
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13. Co-transcriptional Mechanisms o
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14. Chemical Biology and Therapeuti
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15. Development of Enabling Technol
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269 IFMs in 20091. “Alternative a
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18. Career DevelopmentWorkpackage d
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20. SMEs and Technology TransferWor
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21. Reachout to the Broader RNA Com
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15.7 WORK PACKAGE LIST (MONTHS 37-5
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 286 and 287:
AMU 5 29 8 42UAAR 5 145 16 1665 29
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Joint Programme of Activities RESEA
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60 month period 18 month periodRequ
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Integration1. Young Investigator Pr
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UCAM-DBIOC 2350,000x1/3 € 50,000x
Page 296:
the management team. Audit costs ar
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