PDF file: EURASNET Annual Report 2008

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Report on the Distribution of the Community's contributionType of Instrument NoE Project Title (or Acronym) EURASNET Contract N° 518238Part II Distribution of the Community's prefinancing (or payment) between contractors according to the consortium decision(s) (4)Reporting Period 1 Reporting Period 2 Reporting Period 3 Reporting Period 4 Reporting Period 5 Reporting Period 6 Reporting Period 7 Final paymentContractorn°Total (Y)Organisation ShortNameCountryCode23 UCAM-DBIOC UK24 HUJI IL25 IGMBC-GIE FR26 INSERM FR27 FCSR IT28 ISB-SIB CH29 ETHZ CH30 IIMCB PL31 UPF ES32 SOTON-HGD UKDate(s) (5)Amount(s)(A') (5)Date(s) (5)Amount(s)(B') (5)Date(s) (5)Amount(s)(C') (5)Date(s) (5)Amount(s)(D') (5)Date(s) (5)27.01.2006 51.000,00 21.04.2008 40.000,00 91.000,0028.11.2006 16.000,00 16.000,008.12.2006 4.500,00 4.500,000,00Total 71.500,00 Total 0,00 Total 40.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 111.500,0027.01.2006 51.000,00 21.04.2008 40.000,00 91.000,000,000,000,00Total 51.000,00 Total 0,00 Total 40.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 91.000,0027.01.2006 51.000,00 21.04.2008 40.000,00 91.000,000,000,000,00Total 51.000,00 Total 0,00 Total 40.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 91.000,0021.07.2006 34.000,00 21.04.2008 40.000,00 74.000,0022.12.2008 27.728,18 27.728,180,000,00Total 34.000,00 Total 0,00 Total 67.728,18 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 101.728,1828.08.2006 34.000,00 21.04.2008 40.000,00 74.000,000,000,000,00Total 34.000,00 Total 0,00 Total 40.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 74.000,0021.07.2006 34.000,00 21.04.2008 40.000,00 74.000,000,000,000,00Total 34.000,00 Total 0,00 Total 40.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 74.000,0021.04.2008 17.000,00 17.000,000,000,000,00Total 0,00 Total 0,00 Total 17.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 17.000,0021.04.2008 17.000,00 17.000,000,000,000,00Total 0,00 Total 0,00 Total 17.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 17.000,0021.04.2008 17.000,00 17.000,000,000,000,00Total 0,00 Total 0,00 Total 17.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 17.000,0021.04.2008 17.000,00 17.000,000,000,000,00Total 0,00 Total 0,00 Total 17.000,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 17.000,00Total 2.318.742,69 Total 165.788,50 Total 2.033.188,90 Total 0,00 Total 0,00 Total 0,00 Total 0,00 Total 0,00 4.517.720,09Amount(s)(E') (5)Date(s) (5)Amount(s)(F') (5)Date(s) (5)Amount(s)(G') (5)Date(s) (5)Amount(s)(H') (5)Total Amount(I') (6)Part IIIDifference between Community's prefinancing (or payment) sent to the coordinator and Total Distribution of the Community's prefinancing (or payment) between contractors according to the consortiumdecision(s) (4)Reporting Period 1 Reporting Period 2 Reporting Period 3 Reporting Period 4 Reporting Period 5 Reporting Period 6 Reporting Period 7 Final paymentTotal AmountCommunity's prefinancing (or payment) not yetdistributed between contractors (Z) (7)231257,31 -165788,50 1956874,180,00 0,00 0,00 0,000,002022342,99I certify that the information set out in this(these) form(s) is accurate and correct and agreed by all contractors.Name (8) Surname (8)Date(dd/mm/yyyy)Signature of the administrative official authorised to commit the organisation of the coordinator (8)MANFREDMESSERSCHMIDT205Explanatory notes Page n° / 3(1): To be filled in only by the coordinator. (2): Established in conformity with articles 4.2 and 6 of the contract.(3): (I) = (A) + (B) + (C) + (D) + (E) + (F) + (G) + (H) (4): To be filled in only by the coordinator.(5): Insert the dates (dd/mm/yyyy) and the amounts (x,xxx.xx !) transferred to a contractor (including the coordinator) for a reporting period. If there are more than one transfer to a contractor during a reporting period, identify each date and each relating transferred amount.(6): (I') = (A') + (B') + (C') + (D') + (E') + (F') + (G') + (H') (7): (Z) = (X) - (Y)(8): One the following persons : authorised contact person or first or second administrative official authorised to sign the contract, as mentioned in your Contract Preparation Form (Form A2b)3
14 SUMMARY EXPLANATION OF THE IMPACT OF MAJOR DEVIATIONSFROM COST AND PERSON MONTH BUDGETThe EC payment for 2007 was received in April 2008 only and was immediately distributed to members. The ECpayment for 2008 has been received December 31, 2008. It could therefore be distributed only in January 2009.The REPORT ON THE DISTRIBUTION OF THE COMMUNITY'S CONTRIBUTION (Section 13) thereforeshows a non-distributed amount of 1.956.874,18 Euro. This does therefore not constitute underspending.Transfers from the Coordinator's escrow account made in 2008 are listed in the justification of major cost itemsfor participant 1a (coordinator). Eurasnet partner Stefan Stamm (#3) receives money until the end of February2008 (the termination of his status as Eurasnet member). Stefan Stamm continued to work on EURASNETdeliverables during all of 2008 and will continue to work on the completion of his deliverables of the JPA month25-42. Future PMs originally assigned to him will be shouldered by other network members. We thereforeinclude in this Report 2008 an updated table PM Efforts for the full duration of the project (Section 15.9) whichshows how the PM have been redistributed. Due to the unclear situation of his status he did not receive fundsduring 2007/2008 and his final payment will be made in 2009 only (that is balancing and closing his Erlangenaccount with the date Feb 29, 2008). The research funds assigned to University Erlangen (Stefan Stamm) inAnnex I remain under the control of the coordinator and will be distributed for tasks previously assigned to St.Stamm following case by case decisions. As already mentioned in our 2007 Annual Report, the website-relatedtasks and connected funds were switched to Eurasnet member John Brown (#14) effective July 1, 2007. Thishappened also in anticipation of a possible move of Stefan Stamm. An amendment request addressing theleaving of Stefan Stamm is submitted with this Annual Report 2008.Steering Committee and Coordinator hold the firm opinion that the contact to clinical practitioners is of highestimportance to establish the awareness of the connections of alternative splicing and disease processes in themedical community. In this view we are supported by our Scientific Advisory Board. As already pointed out inour reply letter to the 2007 Reviewer's Report, EURASNET is striving to give this connection to practitioner anddiagnosis a stronger standing within the framework of EURASNET. EURASNET therefore decided inNovember 2008 to support a proposal brought forth by Eurasnet partner 32 Diana Baralle, University ofSouthampton. In a flagship study in cooperation with the National Genetics Reference Laboratory, UK Eurasnetwill explore the needs, technical aspects and quality assurance of RNA analysis as a means of interpretingsequence variants. Principal investigator for this study is Diana Baralle. Eurasnet supports this study with 60.000Euros for a one year scientist position. These funds originate from money saved during the cost-efficientorganisation of workshops and meetings and in particular the cost-efficient operation of the EURASNETwebsite.Partner 32 does not claim eligible costs for 2008. The explanation is given in the justification section 10.32.15 JOINT PROGRAM OF ACTIVITIES (MONTH 25-42, JAN 2008-JUNE 2009)15.1 THE FUTURE OF EURASNET RESEARCH: GOALS AND OBJECTIVESAFTER TWO YEARSTwo years into the network, EURASNET thought it appropriate to reconsider its goals and perspectives, itsapproaches and structures. To this purpose the coordinator convened a PI-only session during the IFM onBiophysical Methods, Berlin January 2008. Taking into consideration achievements and deficits of the last twoyears, surveying the rapidly evolving field of alternative splicing with many new technologies and researchoptions emerging, network members discussed where new avenues of research should be ventured and whereoutdated goals should be abandoned.206
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TABLE OF CONTENTSA. PERIODIC ACTIVI
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1 PUBLISHABLE EXECUTIVE SUMMARY EUR
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Dr. Davide Gabellini(28) Swiss Inst
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WP7 Molecular characterization of s
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To identify protein-protein interac
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expressed in a particular tissue. T
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Duchenne muscular dystrophy (DMD).
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WP21 Reachout to the broader RNA co
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4.1 TABLE OF MILESTONES JPA MONTH 2
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Numerous plasmids, constructs, extr
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collaboration between EURASNET and
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5.1 WORK PACKAGE REPORTSWork Packag
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• Ongoing regular addition of new
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Work Package 4 The Alternative Spli
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Work Package 6 In silico approaches
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alternative splicing.162 Compare sp
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33 Agreement on pre-mRNA substrates
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its numerous binding sites on both
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Work Package 8 Genome-wide Analyses
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173 Further development of data ana
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Problems and explanations for delay
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eveal that there is a dramatic chan
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Work Package 10 Post-translational
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mutational analysis that led to the
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Isolation of an active step I splic
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FBP11 and 21 with these sequences.
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Similarly to what observed for SF2/
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prp45-113 mutant, which is compatib
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cell lines. In contrast in the pres
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genes with roles in the development
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Structural analyses of several RRMs
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Work Package 17 Staff Exchange and
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Barralle's lab, Krämer is acting a
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alternative splicing) and higher ed
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Student Symposium “Decision Makin
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variation and suitability for use w
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Following feedback from members we
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Invited seminars: In addition to me
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Publications 2008Author Title Publi
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Author Title Publication EURASNET P
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Minutes of the General Assembly dec
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241 Evaluate available careerdevelo
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156 The EURASNET memberStamm publis
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y coarse-grained foldingsimulation.
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overexpressor and mutant lines(mont
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machinery with particularrespect to
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alternative splicing, using theEDI
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contemporary findings withinthe EUR
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Licht K, Medenbach J, Lührmann R,K
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9 TABULAR OVERVIEW OF MAJOR COST IT
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total costs * 18.891,12 52778.60 41
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other (the rest) 48,57 0 56.539,43t
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travel 6.964,91overhead 3.081,07oth
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Participant 1A Type of expenditure
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Participant 1B - Karla Neugebauera)
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Participant 2 - Juan Valcarcela) Wo
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Participant 3 - Stefan Stamma) Work
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Participant 4 - Göran Akusjärvia)
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Participant 5A/B - Peer Bork/Rolf A
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Major cost items• ResearchPersonn
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Participant 7 - Francisco Barallea)
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Francisco Baralle gave a talk to a
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alternative splicing on human disea
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J. Beggs has had frequent contact w
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Page 156 and 157: Participant 12A - Jamal Tazia) Work
Page 158 and 159: Participant 12B - Bertrand Séraphi
Page 160 and 161: Participant 12C - Christiane Branla
Page 162 and 163: Participant 12D - Edouard Bertranda
Page 164 and 165: Participant 13 - Daniel Schümperli
Page 166 and 167: Participant 14 - John W. S. Browna)
Page 168 and 169: Participant 15 - Javier F. Cáceres
Page 170 and 171: • ResearchPersonnelName WP Person
Page 172 and 173: MiscellaneousOligonucleotidesUse of
Page 174 and 175: Major cost items• ResearchConsuma
Page 176 and 177: Major cost items• ResearchPersonn
Page 178 and 179: Participant 21 - Angela Krämera) W
Page 180 and 181: Participant 22 - Angus Lamonda) Wor
Page 182 and 183: Participant 23 - Chris Smitha) Work
Page 184 and 185: ChemicalsEnzymesLaboratory supplies
Page 186 and 187: Participant 26 - Didier Auboeufa) W
Page 188 and 189: tool for the molecular analysis of
Page 190 and 191: Participant 29 - Frédéric Allaina
Page 192 and 193: protein and instead possesses the d
Page 194 and 195: + overhead 4.730= total eligible co
Page 196 and 197: Claudia Tamaro (PhD) has begun work
Page 198 and 199: ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
Page 200 and 201: Direct eligible costs 53.240,48 0,0
Page 202 and 203: Direct eligible costs 18.720,07 0,0
Page 204 and 205: 13 REPORT ON THE DISTRIBUTION OF TH
Page 208 and 209: For most work packages here follows
Page 210 and 211: pathways (eg, Reactome ).While PAND
Page 212 and 213: The possible dependence of the effe
Page 214 and 215: In some treatments or mutants, simi
Page 216 and 217: Work Package 12: Mis-splicing and D
Page 218 and 219: acid. Furthermore, using antibodies
Page 220 and 221: At the 2007 annual meeting in Ile d
Page 222 and 223: Partner 13 has extensively studied
Page 224 and 225: inhibitors/modulators of RNA splici
Page 226 and 227: 18 MONTH JPA: WORKPACKAGE TIMECOURS
Page 228 and 229: 15.3 GRAPHICAL PRESENTATION OF WORK
Page 230 and 231: 15.4 TABLE OF MILESTONES (MONTH 37-
Page 232 and 233: 156 The EURASNET memberStamm publis
Page 234 and 235: 194 Bertrand will analyze indetail
Page 236 and 237: 216 Aubeouf and Neugebauer willcoll
Page 238 and 239: 238 Establishing joint PhDcommittee
Page 240 and 241: 283 A unified browser for allknown
Page 242 and 243: 296 Group 12a (Branlant) willuse th
Page 244 and 245: 315 Lamond will use a FLIM-FRET bas
Page 246 and 247: 329 GROUP 7 (F. BARALLE)will contin
Page 248 and 249: 333 GROUP 27 (GABELLINI)will:1) foc
Page 250 and 251: 345 Schümperli’s group isplannin
Page 252 and 253: 366 Quarterly network e-mail atmont
Page 254 and 255: 2. Sharing Resources, Technology an
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5. Ensuring DurabilityWorkpackage d
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7. Molecular Characterization of Sp
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8. Genome-wide Analyses of Splicing
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9. Complexity of Spliceosomal Prote
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202 Srebrow will investigate the ro
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12. Mis-splicing and DiseaseWorkpac
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13. Co-transcriptional Mechanisms o
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14. Chemical Biology and Therapeuti
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15. Development of Enabling Technol
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269 IFMs in 20091. “Alternative a
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18. Career DevelopmentWorkpackage d
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20. SMEs and Technology TransferWor
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21. Reachout to the Broader RNA Com
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15.7 WORK PACKAGE LIST (MONTHS 37-5
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ETHZIIMCBUPFSOTON-HGDTOTALJoint Pro
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AMU 5 29 8 42UAAR 5 145 16 1665 29
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Joint Programme of Activities RESEA
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60 month period 18 month periodRequ
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Integration1. Young Investigator Pr
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UCAM-DBIOC 2350,000x1/3 € 50,000x
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the management team. Audit costs ar
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