PDF file: EURASNET Annual Report 2008

320 Tazi has identified theDrosophila brain tumor (brat)gene among the proteins thatsuppress the deleteriousdevelopmental effect of B52overexpression. This geneencodes a member of theconserved NHL family ofproteins, which appears toregulate differentiation andgrowth in a variety oforganisms. Current studiesabout the mechanism bywhich Brat interfere with thefunction of B52, revealed thatBrat is required fortranslational repression of theproto-oncogene dmyc, whoseexpression is under thecontrol of B52. Ongoingexperiments are aimed atdeciphering the mechanismby which B52 modulate theexpression of dmyc.321 Srebrow will continue herreseach on the role of Akt as anovel SR protein kinase. Theywill also pursue the study ofthe connection betweenSUMOylation and splicingfactors, focusing on how SRprotein activity regulatesglobal protein SUMOylation.322 Functional analysis of brainamdmuscle-specific isoformsof the splicing regulator Fox-1(month 54)323 Selective targeting of CBP20isoforms to verify if theyprovide an essential function(month 54)324 Targeting of SR proteins totheir own genes (month 54)325 Determine the RNA isoformsgenerated from the snoRNAHBII-52 and determine theirinfluence on six target genes(month 54)326 Functions of adenovirus L4protein isoforms (month 54)327 HITS-CLIP of SF1 isoforms(month 54)328 Analysis of consequences ofalternative splicing upon theactivity of isoforms of ROD1and QKI (month 54)10 Caceres O CO 5410 Caceres O CO 5411 Valcarcel O CO 5411 Valcarcel O CO 5411 Valcarcel O CO 5411 Valcarcel O CO 5411 Valcarcel O CO 5411 Valcarcel O CO 5411 Valcarcel O CO 54244