PDF file: EURASNET Annual Report 2008

283 A unified browser for allknown splicing regulatorysequences in exons and theirflanking introns.284 Group 12c (Branlant) willcomplete the analysis oflamin A pre-mRNAsecondary structure, andstudy in collaboration withGroup 12a (Tazi) andGroup 25 (Stévenin) theinfluence of this structure onpatterns of alternative splicingand binding of regulatorysplicing factors. Theimportance for splicingregulations of the 2Dstructures established for theSC35 terminal exon and thehcTNT exon 5 and itsbordering intronic sequenceswill be investigated(collaboration with group 25).For a better understanding ofTau pre-mRNA deregulationslinked to DM1 and DM2, thesecondary structure of theTau pre-mRNA regioncontaining the alternativeexons 2 and 3 will beestablished.285 Group 7 ( F Baralle) willcontinue to study of theinfluence of the 2D structureof regulatory elements infibronection EDA gene onalternative splicing, and thepossible effects of alterationsof pre-mRNA HEXB 2Dstructure in link with theSandhoff disease.286 Group12c (Branlant) incollaboration with Group 10a(G Biamonti) will determinethe 2D structure of Sat IIIrepeated RNAs which areexpressed in several stressconditions, and areresponsible for nuclear stressbody formation, where someof the splicing regulatoryproteins (SR and hnRNPs,especially ASF/SF2) areconcentrated.287 Group 7 (F Baralle) willcontinue in collaboration withGroup 32 (D Baralle) toidentify transacting factors forexon 37 inclusion in NF1mRNA.6 Ast O CO 547 Branlant O CO 547 Branlant O CO 547 Branlant O CO 547 Branlant O CO 54239