PDF file: EURASNET Annual Report 2008

Isolation of an active step I spliceosome and composition of its RNP core. Nature, 452, 846-850.Biamonti,G. and Cáceres,J.F. (2009) Cellular stress and RNA splicing. Trends Biochem..Sci., in press.Ellis,J.D., Lleres,D., Denegri,M., Lamond,A.I. and Cáceres,J.F. (2008) Spatial mapping of splicing factor complexesinvolved in exon and intron definition. J.Cell. Biol., 181, 921-934Comment/ Reviews on this paperRobinson,R. (2008) A better way to see splicing partners. J. Cell Biol., 181, 875.Grosso,A.R., Martins,S. and Carmo-Fonseca,M. (2008) The emerging role of splicing factors in cancer. EMBO Rep., 9,1087-1093.Herold,N., Will,C.L., Wolf,E., Kastner,B., Urlaub,H. and Lührmann,R. (2009) Conservation of the protein compositionand electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol Cell Biol., 29,281-301.Kuhn,A.N., van Santen,M.A., Schwienhorst,A., Urlaub,H. and Lührmann,R. (2009) Stalling of spliceosome assembly atdistinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA, 15, 153-175.Mathew,R., Hartmuth,K., Mohlmann,S., Urlaub,H., Ficner,R. and Lührmann,R. (2008) Phosphorylation of human PRP28by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. Nat. Struct. Mol. Biol., 15, 435-43.Comment/ Reviews on this paperMaeder,C. and Guthrie,C. (2008) Modifications target spliceosome dynamics. Nat. Struct. Mol. Biol., 15, 426-428.Michlewski,G., Sanford,J.R. and Cáceres,J.F. (2008) The splicing factor SF2/ASF regulates translation initiation byenhancing phosphorylation of 4E-BP1. Mol Cell., 30, 179-189.Comment/ Reviews on this paperBushell,M., Stoneley,M., Spriggs,K.A. and Willis,A.E. (2008) SF2/ASF TORCs Up Translation. Mol Cell, 30, 262-263Rino,J., Desterro, J.M., Pacheco,T.R., Gadella,T.W. and Carmo-Fonseca,M.A. (2008) Splicing factors SF1 and U2AFassociate in extra-spliceosomal complexes. Mol.Cell.Biol., 28, 3045-57.Sanford,J.R., Coutinho,P., Hacket, J.A., Wang,X., Ranahan,W. and Cáceres,J.F. (2008) Identification of nuclear andcytoplasmic mRNA targets for the shuttling protein SF2/ASF. PLoS ONE, 3(10): e3369.Stamm,S. (2008) Regulation of alternative splicing by reversible phosphorylation. J.Biol. Chem., 283, 1223-1227.Sumanasekera, C., Watt,D.S. and Stamm,S. (2008) Substances that can changealternative splice-site selection. Biochem. Soc. Trans., 36, 483-490.Tazi,J., Bakkour,N. and Stamm,S. (2009) Alternative splicing and disease. Biochim Biophys Acta. 1792, 14-26.Valgardsdottir,R., Chiodi,I., Giordano,M., Rossi,A., Bazzini,S., Ghigna,C., Riva,S. and Biamonti,G. (2008) Transcription ofSatellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res., 36, 423-434.Yu,Y., Maroney,P.A., Denker,J.A., Zhang,X.H., Dybkov,O., Lührmann,R., Jankowsky,E., Chasin,L.A. and Nilsen,T.W.(2008) Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition. Cell, 135, 1224-1236.MANUSCRIPTSBackstrom,E., Kaufmann,K. and Akusjarvi,G. The adenovirus L4-22K protein is a keyviral transcriptional regulator. Manuscript in preparation.Juge,F., Fic,W, Fernando,C. and Tazi,J. Coordinated action of the splicing factor B52 and DNA topoisomerase I inDrosophila development. submitted for publication.Tuduri.S, Crabbe,L., Tourriere,H., Conti,C., Jauch,A., Pantesco,V., de Vos,J., Theillet,C., Pommier,Y., Tazi,J., Coquelle,A.and Pasero,P. Topoisomerase I suppresses genomic instability by preventing interference between transcription and DNAreplication. Nat. Cell Biol., under revision.50