Final Program

96 SUNDAY • MAY 15
P450
P451
A74
Cleavage Factor Im 25 (CFIM25) Regulates Pulmonary Fibrosis
Through Alternative Polyadenylation/T.W. Mills, N.-Y. Chen, J.
Molina, H. Karmouty-Quintana, K.M. Philip, F. Luo, J. Davies, E.J.
Wagner, M.R. Blackburn, Houston, TX, p.A2423
Activated Primary Human Lung Fibroblasts Produce
Anti-Inflammatory and Anti-Fibrotic Peroxisome
Proliferator-Activated Receptor Gamma (PPARg) Ligands/
S.H. Lacy, C.F. Woeller, T.H. Thatcher, P.J. Sime, R.P. Phipps,
Rochester, NY, p.A2424
THEMATIC POSTER SESSION
MATRIX: DRIVERS AND TARGETS
9:00 a.m. - 4:15 p.m. MOSCONE CENTER
Viewing: Posters will be on display for entire session.
Area D, Hall D (North Building, Lower Level)
Discussion: 11:00-11:45: authors will be present for individual discussion
11:45-12:45: authors will be present for discussion with assigned facilitators
P453
P454
P455
P456
P457
P458
P459
P460
Sirtuin 7 Is Associated with Pulmonary Fibrosis and
Attenuates Collagen Expression in Lung Fibroblasts/A.E.
Wyman, Z. Noor, N.W. Todd, I.G. Luzina, S.P. Atamas, Baltimore,
MD, p.A2425
Regulation of Non-Muscle Myosin Light Chain Kinase
Alternative Splicing by Mechanical Stress and Genetic
Influences/J.B. Mascarenhas, G.T. Kelly, A.Y. Tchourbanov, T.
Zhou, S.M. Danillov, T. Wang, J.G.N. Garcia, Tucson, AZ, p.A2426
Post-Transcriptional Regulation of NOX4 by the
Mechanosensing ROCK/mTOR Pathway/A. Venado, H. Chen, J.
Qu, N.J. Logsdon, Y. Zhou, V.J. Thannickal, Birmingham, AL,
p.A2427
Patterns of Elastic Fiber Breakdown in Bleomycin-Induced
Fibrosis and Elastase-Induced Emphysema May Reflect
Pulmonary Microarchitectural Changes/X. Liu, S. Ma, G. Turino,
J. Cantor, Queens, NY, p.A2428
XPLN Negatively Regulates SPARC Expression by Targeting
mTORC2 in Human Lung Fibroblasts/K. Kamio, A. Azuma, J.
Usuki, K. Matsuda, M. Inomata, N. Nishijima, S. Itakura, N. Kokuho,
H. Hayashi, T. Yamaguchi, K. Fujita, Y. Saito, S. Abe, K. Kubota, A.
Gemma, Tokyo, Japan, p.A2429
Expression of Extracellular Matrix Constituents by Fibroblasts
Conditioned by Bronchial Epithelial Cells (BECs) from
Asthmatic and Healthy Children Is Correlated with Lung
Function Measures of BEC Donors/S.R. Reeves, T.K. Kolstad, A.
Arrigoni, K. Barrow, J.S. Debley, Seattle, WA, p.A2430
Loss of Fatty Acid Synthase Increases the Severity of Lung
Fibrosis by Preventing Collagen Resorption/D. McCarthy, A.K.
Soltani, A. Ha, K. Atabai, San Francisco, CA, p.A2431
Type I Collagen Signaling Regulates Fibroblast Activation,
Proliferation, and Apoptosis/S. Jia, J.C. Horowitz, T. Loo, M.
Agarwal, K.K. Kim, Ann Arbor, MI, p.A2432
P461
P462
P463
P464
P465
P466
P467
P468
P469
P470
P471
P472
Expression of Heparan Sulfate and Heparan Sulfate
Proteoglycans in Idiopathic Pulmonary Fibrosis/X. Yue, M.A.
Jessee, New Orleans, LA, p.A2433
Serum Matrix Metalloproteinase-7 Is a Potential Marker of
Active Disease in Patients with Idiopathic Pulmonary Fibrosis/
J. Jaffar, K. Symons, N. Goh, R. O’Hehir, M. Schuliga, A.G.
Stewart, G. Westall, I. Glaspole, Melbourne, Australia, p.A2434
Inhibition of Lysyl Oxidase Enzyme Activity In Vitro Inhibits
TGF-b Induced Collagen Remodeling in 3D Collagen Models/
G. Tjin, E.S. White, E.P.W. Kable, J.K. Burgess, Sydney, Australia,
p.A2435
Tissue Turnover of Collagen Type I, III and Elastin Are
Elevated in the Rat Precision-Cut Lung Slice Model of IPF and
Can Be Restored Back to Vehicle Levels Using a PDE
Inhibitor/N.U.B. Hansen, M.A. Karsdal, S. Brockbank, S. Cruwys,
A. Young, P. Nath, D.J. Leeming, Herlev, Denmark, p.A2436
Assessment of Clinically Relevant Extracellular Matrix Markers
in a Bleomycin-Induced Model of Lung Fibrosis in the
Mouse/A. Young, S. Brockbank, N.U.B. Hansen, M.A. Karsdal, D.J.
Leeming, P. Nath, V. Russell, E. Sadler, S. Cruwys, Harlow, United
Kingdom, p.A2437
Serum Syndecan-1 in Patients with Acute Exacerbation of
Idiopathic Interstitial Pneumonia/R. Togawa, Y. Tanino, T.
Nikaido, K. Misa, Y. Sato, Y. Suzuki, M. Uematsu, A. Fukuhara, S.
Sato, J. Saito, X. Wang, M. Munakata, Fukushima, Japan, p.A2438
Inhibition of Extracellular Matrix Cross-Linking Affects
Proliferation, Adhesion and Proteolysis of Extracellular Matrix
Derived from IPF Fibroblasts and Aids Resolution in the
Murine Bleomycin Model/C.J. Philp, I. Siebeke, D. Clements, A.E.
John, A. Habgood, R.G. Jenkins, S.R. Johnson, Nottingham, United
Kingdom, p.A2439
Extracellular Matrix Changes After Repetitive Instillations of
Whole Gastric Contents in the Rat Lung/P. Ayala, M. Meneses,
J. Torres, J. Araos, G.R. Borzone, Santiago, Chile, p.A2440
Lysyl Oxidase Induces Fibrosis Via Upregulation of IL-6 and
Serves as a Biomarker to Monitor Response to Therapy/T.
Nishimoto, T. Takihara, L. Mlakar, J. Heywood, A. Bradshaw, C.
Feghali-Bostwick, Charleston, SC, p.A2441
Senescent Stroma-Induced Oncogenesis in Idiopathic
Pulmonary Fibrosis/D.M. Habiel, N. Krepostman, M. Lilly, T.
Shibata, K. Cavassani, A.L. Coelho, A. Kurkciyan, V. Funari, C.A.
Henke, B. Stripp, W. Parks, P. Chen, D. Jiang, P.W. Noble, K.
Elenitoba-Johnson, C. Hogaboam, Los Angeles, CA, p.A2442
Clinically Validated Serum Extracellular Matrix Turnover
Markers of IPF in Combination with a Bleomycin In-Vivo and an
Ex-Vivo Model May Be Used as an Intelligent Drug Screening
Tool/D.J. Leeming, S. Brockbank, N.U.B. Hansen, M.A. Karsdal, P.
Nath, D. Rider, V.P. Russel, E. Sadler, A. Young, S. Cruwys,
Herlev, Denmark, p.A2443
Differential Responses to the Protein Components of the
SSc-ILD lung Extra-Cellular Matrix by Control and SSc-ILD
Fibrocytes/H. Sun, H. Pan, H. Ding, Y. Cheng, M. Gulati, W.H.
Fares, P. Adonteng-Boateng, D.A. Carrano, D.E. Antin-Ozerkis, C.
Ryu, X. Peng, E. Herzog, New Haven, CT, p.A2444
ATS 2016 • San Francisco