Final Program
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SUNDAY • MAY 15 33<br />
A13<br />
MINI SYMPOSIUM<br />
NOVEL INNATE IMMUNE PATHWAYS IN SEVERE<br />
ASTHMA<br />
9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />
Room 2005/2007 (West Building, Level 2)<br />
Chairing: K.F. Chung, MD, PhD, London, United Kingdom<br />
M. Idzko, MD, Freiburg, Germany<br />
R.W. Harper, MD, Sacramento, CA<br />
Oral Presentations<br />
9:00 Macrophage Inflammasome Activation in Sputum from Severe<br />
Asthmatics/S. Pavlidis, C. Rossios, M. Loza, F. Baribaud, A.<br />
Rowe, C.H.S. Kuo, R. Lutter, U. Hoda, I. Pandis, Y.-K. Guo, A.R.<br />
Sousa, J. Corfield, P.J. Sterk, R. Djukanovic, I. Adcock, K.F.<br />
Chung, High Wycombe, United Kingdom, p.A1001<br />
9:15 NLRP3 Inflammasome-Mediated, IL-1b-Dependent<br />
Inflammatory Responses Drive Severe, Steroid-Insensitive<br />
Asthma/R.Y. Kim, J.W. Pinkerton, A.-T. Essilfie, A.A. Robertson,<br />
K.J. Baines, J.R. Mayall, M.R. Starkey, P.A. Wark, P.G. Gibson,<br />
L.A. O’Neill, J.C. Horvat, M.A. Cooper, P.M. Hansbro, New<br />
Lambton Heights, Australia, p.A1002<br />
9:30 Overexpression of Gasdermin B, a Gene Target of the 17q12<br />
Asthma-Susceptibility Regulatory Haplotype, Accentuates<br />
Allergic Airway Inflammation/N. Krishnamoorthy, X. Zhou, M.A.<br />
Perrella, B.D. Levy, B.A. Raby, Boston, MA, p.A1003<br />
9:45 Airway Epithelial DUOX1 Mediates EGFR Activation, Mucus<br />
Metaplasia, and Remodeling During Allergic Asthma/A. Van Der<br />
Vliet, M. Hristova, A. Habibovic, D. Heppner, Y. Janssen-Heininger,<br />
C.G. Irvin, M.E. Poynter, L.K.A. Lundblad, A.E. Dixon, M. Geiszt,<br />
Burlington, VT, p.A1004<br />
10:00 Role of Interferon Regulatory Factor-1 (IRF-1) in Modulating<br />
Steroid Insensitive Pathways in Severe Asthma/A. Gavrila, L.<br />
Chachi, O. Tliba, C.E. Brightling, Y. Amrani, Leicester, United<br />
Kingdom, p.A1005<br />
10:15 P2Y6R Signaling: A Double-Edged Sword in Allergen-Induced<br />
Airway Inflammation/A. Zech, A. Meyer, M. Idzko, Freiburg,<br />
Germany, p.A1006<br />
10:30 1,25D3 Prevents CD8+Tc2 Skewing and Asthma Development<br />
Through VDR Binding Changes to the Cyp11a1 Promoter/M.<br />
Schedel, Y. Jia, S. Michel, K. Takeda, J. Domenico, A. Joetham, M.<br />
Strand, J. Han, M. Wang, J.L. Lucas, C. Vogelberg, E.W. Gelfand,<br />
M. Kabesch, B.P. O’Connor, Denver, CO, p.A1007<br />
10:45 TSLP in Patients with Asthma, COPD and ACOS/P. Korosec, S.<br />
Korn, S. Skrgat, R. Marcun, R. Buhl, M. Flezar, Golnik, Slovenia,<br />
p.A1008<br />
A14<br />
MINI SYMPOSIUM<br />
ADVANCE CARE PLANNING AND PALLIATIVE<br />
CARE: PATIENTS TO POLICY<br />
9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />
Chairing: R.D. Stapleton, MD, PhD, Burlington, VT<br />
E.K. Kross, MD, Seattle, WA<br />
Oral Presentations<br />
Room 307 (South Building, Esplanade Level)<br />
9:00 Validation of a Prognostic Model to Predict 6-Month Mortality<br />
in Medical Intensive Care Unit (MICU) Patients/R.G. Sangani, K.<br />
Chapman, S. Hadique, S. Culp, S. Khan, J.E. Parker, A. Moss,<br />
Morgantown, WV, p.A1009<br />
9:15 Principles of End-of-Life Care for the Critically Ill: Sources of<br />
Variability in Opinions About Autonomy, Advance Directives,<br />
and Intensive Care Unit Interventions/A.C. Long, L. Downey,<br />
E.K. Kross, R.A. Engelberg, M. Baras, J.R. Curtis, C.L. Sprung,<br />
Seattle, WA, p.A1010<br />
9:30 What Is Palliative Care’s Secret Ingredient? How Intensivists<br />
and Palliative Care Physicians Navigate Communication with<br />
Surrogates About a Patient’s Values and Preferences in<br />
High-Fidelity Simulation/L.P. Scheunemann, P.S. Rajagopal,<br />
R.M. Arnold, D.B. White, Pittsburgh, PA, p.A1011<br />
9:45 Using the Early Warning System (EWS) to Identify and<br />
Establish Goals of Care/Advanced Directives in a High Risk<br />
Patient Population: A Randomized, Prospective Trial/D. Picker,<br />
M. Dans, T. Bailey, K. Heard, M.H. Kollef, St. Louis, MO, p.A1012<br />
10:00 Attitudes of Critical Care Clinicians Toward the Use of Triggers<br />
for Intensive Care Unit-Based Palliative Care Consultation/<br />
N.G. Wysham, D.M. Jones, W. Reagan, H. Goucher, S. Gundel,<br />
C.T.L. Hough, J. Mcfarlin, M. Hua, C.E. Cox, Durham, NC, p.A1013<br />
10:15 Advance Directives and Their Impact on Real-World Stability of<br />
End-of-Life Preferences in Hospitalized Patients/Y.S. Kim, V.<br />
Liu, P. Scheirer, J.D. Greene, G.J. Escobar, Oakland, CA, p.A1014<br />
10:30 The Association Between Hospice Utilization and Performance<br />
on Publicly Reported Outcome Measures/S. Lah, E. Wilson,<br />
S.M. Brown, Murray, UT, p.A1015<br />
10:45 Do Not Resuscitate Orders with Unplanned Hospital Readmission<br />
Quality Measures in Pneumonia/A.B. Mehta, C.R. Cooke, I.S. Douglas,<br />
P.K. Lindenauer, R.S. Wiener, A.J. Walkey, Boston, MA, p.A1016<br />
A15<br />
MINI SYMPOSIUM<br />
EMERGING DATA ON COPD EXACERBATIONS<br />
9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />
Room 130-132 (North Building, Lower Level)<br />
Chairing: J.A. Wedzicha, MD, PhD, London, United Kingdom<br />
E.C. Oelsner, MD, MPH, New York, NY<br />
S. Sethi, MD, Buffalo, NY<br />
SUNDAY MORNING<br />
ATS 2016 • San Francisco