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348 WEDNESDAY • MAY 18<br />

216 Simplifying the Cardiopulmonary Exercise Test Enables<br />

Pattern Recognition and Differentiation Between Diseases<br />

Causing Exertional Dyspnea/K.H. Melamed, B. Dolezal, X. Wang,<br />

C.B. Cooper, Los Angeles, CA, p.A6531<br />

217 Absolute Lung Volume and Breathlessness in Men and Women<br />

in the General Population/M. Ekstrom, L. Schioler, R. Gronseth,<br />

A. Johannessen, C. Janson, C. Svanes, B. Leynaert, D. Jarvis, K.<br />

Toren, Lund, Sweden, p.A6532<br />

218 Validation of the Objective Simplified Wells Score and<br />

Comparison with Clinical Judgement/J. Seashore, M. Farokhi,<br />

J.P. Wisnivesky, O. Epelbaum, Queens, NY, p.A6533<br />

219 Patient Reported Dyspnea on Standardized Questionnaires<br />

Does Not Correlate with Measurement Of maxVO2 During<br />

Cardio-Pulmonary Exercise Testing/D. Gaspard, S. Akers, J.<br />

Kass, M. Pratter, Camden, NJ, p.A6534<br />

220 Correlation of Self Reported Breathlessness with Post<br />

Exercise Dyspnea in Obesity/M. Agustin, H. Chang, J. Unterborn,<br />

A. Andoh-Duku, Boston, MA, p.A6535<br />

221 Interstitial Lung Disease Patient Diagnostic Journey<br />

(INTENSITY) Survey/P. Bianchi, D.J. Lederer, S. Danese, J.<br />

Loboda, G. Cosgrove, South San Francisco, CA, p.A7894<br />

D24<br />

POSTER DISCUSSION SESSION<br />

GRAM NEGATIVE PNEUMONIAS: FROM BENCH TO<br />

BEDSIDE<br />

9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />

Room 3014 (West Building, Level 3)<br />

Poster Viewing 9:00-9:45<br />

Discussion 9:45-11:00<br />

Chairing: J.E. Chastre, MD, Paris, France<br />

C.S. Dela Cruz, MD, PhD, New Haven, CT<br />

M.S. Niederman, MD, New York, NY<br />

901 Alterations in Pseudomonas Aeruginosa Pathogenicity in<br />

Response to Cigarette Smoke Exposure/M. Ahn, J.H. Hwang, E.<br />

McEachern, L.E. Crotty Alexander, San Diego, CA, p.A6536<br />

902 The Fermentation Product 2,3-butanediol Alters P. aeruginosa<br />

Virulence and the Lung Microbiome/A. Sharma, M. Nguyen, W.<br />

Wu, R. Gomi, L. Angenent, S. Worgall, New York, NY, p.A6537<br />

903 Chitinase 3-Like 1 (Chil1) Regulates Pseudomonas-Induced<br />

Inflammasome Activation Independent of the Inflammasome<br />

Nlrc4 Highlights Importance of Nlrp3 Mediated Lung<br />

Pathology/C.R. Marion, W. Liu, L. Sharma, R. Singh, J. Wang,<br />

C.G. Lee, J.A. Elias, B. Kazmierczak, C. Dela Cruz, New Haven,<br />

CT, p.A6538<br />

904 The Signaling Pathway Involved in MUC1 Mucin Upregulation<br />

in Macrophages During Pseudomonas Aeruginosa Infection/K.<br />

Kato, A. Hanss, N. Morgan, K.S. Knox, E.P. Lillehoj, K.C. Kim,<br />

Tucson, AZ, p.A6539<br />

905 Thrombocytopenia Impairs Host Defence in a Murine Model of<br />

Pulmonary Infection with Psuedomonas Aeruginosa/R.T.<br />

Amison, A. Rossi, S. Ranucci, S. Arnold, S.C. Pitchford, A.<br />

Bragonzi, C.P. Page, London, United Kingdom, p.A6540<br />

906 Interleukin 7 Immunotherapy Improves Survival in Sepsis<br />

Followed by Secondary Pseudomonas Aeruginosa<br />

Pneumonia/Y. Shindo, A.G. Fuchs, C.G. Davis, J. Unsinger, T.<br />

Eitas, C.-A. Burnham, J.M. Green, G.V. Bochicchio, R.S.<br />

Hotchkiss, St. Louis, MO, p.A6541<br />

907 Severity-of-Illness Scores Predict Failure of Antibiotic Therapy<br />

in Pseudomonas Aeruginosa Pneumonia/R.D. Shah, R.G.<br />

Wunderink, Chicago, IL, p.A6542<br />

908 Molecular Characteristics and Epidemiology of Clinically<br />

Tested Non-Extended-Spectrum b-Lactamase<br />

(ESBL)-Producing Klebsiella Pneumoniae Isolates in China/Z.<br />

Zhang, Y. Zhai, Y. Guo, D. Li, Z. Wang, Y. Chen, J. Wang, Q.<br />

Wang, Z. Gao, Beijing, China, p.A6543<br />

909 Promoter-Associated blaSHV Extended-Spectrum<br />

Beta-Lactamases (ESBLs) Phenotypic Silencing in Klebsiella<br />

Pneumoniae/Y. Zhai, Z. Zhang, Y. Guo, Y. Lv, Z. Wang, L. Liu, L.<br />

Xu, D. Yang, R. Li, Y. Xu, J. Yang, Y. Chen, Q. Wang, Z. Gao,<br />

Beijing, China, p.A6544<br />

910 Interleukin (IL)-1a and IL-1b Contribute to Host Defense<br />

Against Pulmonary Klebsiella Infection Via Different<br />

Mechanisms/S. Cai, P. Baral, L. Jin, S. Jeyaseelan, Baton Rouge,<br />

LA, p.A6545<br />

911 Diet-Induced Obesity Impairs Pulmonary Bacterial Clearance<br />

in Klebsiella Pneumonia/P. Mancuso, J.B. Weinberg, K. Singer,<br />

Ann Arbor, MI, p.A6546<br />

912 Epithelial IL-17R Is Required for Pulmonary Host Defense<br />

Against K. Pneumonaie/K. Chen, G. Trevejo-Nunez, E.E. Way,<br />

W. Elsegeiny, D.M. Ricks, A.V. Garg, S.L. Gaffen, J.K. Kolls,<br />

Pittsburgh, PA, p.A6547<br />

913 Effects of Carbapenemase-Producing K. Pneumoniae ST258<br />

on the Components of the Airway Epithelial Barrier/M.<br />

Wickersham, A.S. Prince, D. Ahn, New York, NY, p.A6548<br />

914 ST191 Belonging to CC92 Became Dominate<br />

Carbapenem-Resistant Acinetobacter Baumannii that Cause<br />

Nosocomial Pneumonia in Intensive Care Units in a Teaching<br />

Hospital in Central China/P. Pan, H. Tan, M. Li, X. Su, C. Hu,<br />

ChangSha, China, p.A6549<br />

915 Outcome and Prognostic Factors of Pneumonia Patients with<br />

Acinetobacter Baumannii Bacteremia/W.-C. Liao, C.-H. Chen,<br />

W.-C. Chen, B.-R. Wu, C.-Y. Chen, W.-C. Cheng, T.-C. Hsia, C.-Y.<br />

Tu, Taichung, Taiwan, p.A6550<br />

916 Multidrug Resistance in Acinetobacter Baumannii Pneumonia<br />

and Sepsis Increases the Risk of Receiving Inappropriate<br />

Empiric Treatment/M. Zilberberg, B.H. Nathanson, K. Sulham, W.<br />

Fan, A.F. Shorr, Goshen, MA, p.A6551<br />

917 Effectiveness of High Dose Sulbactam for the Treatment of<br />

Ventilator Associated Pneumonia Caused by Carbapenem<br />

Resistant Acinetobacter Baumanii/I. Jeong, J.W. Son, M.J. Na,<br />

S.J. Kwon, Daejeon, Korea, Republic of, p.A6552<br />

ATS 2016 • San Francisco

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