Final Program

128 SUNDAY • MAY 15
611 Plasma MicroRNAs Expression Associated with Acute
Exacerbation in Idiopathic Pulmonary Fibrosis/D. Jinghong, C.
Hourong, G. Qian, Nanjing, China, p.A2813
612 VEGF Induces Lung Angiogenesis Through “Tailing and
Trimming” of MicroRNAs and Production of 3’-Modified
IsomiRs/A. Korde, L. Dela-Moss, M. Haslip, S. Takyar, New
Haven, CT, p.A2814
613 HIV-1 Nef Downregulates miRNA Expression in Lung Cells/W.
Chatila, M. Santerre, G. Criner, B. Sawaya, Philadelphia, PA, p.A2815
614 Identification of MiR-124 as a Major Regulator of Enhanced
Endothelial Cell Glycolysis in Pulmonary Arterial
Hypertension/P. Caruso, B.J. Dunmore, K. Schlosser, S. Schoors,
C. Dos Santos, C. Perez-Iratxeta, J. Lavoie, L. Long, L. Hurst, M.L.
Ormiston, A. Hata, P. Carmeliet, D.J. Stewart, N.W. Morrell,
Cambridge, United Kingdom, p.A2816
615 Influence of Sex on the miRNA Profile in the Right Ventricle
from Mouse Models of Pulmonary Arterial Hypertension/D.
Morales-Cano, K.M. Mair, N.W. Morrell, F. Perez Vizcaino, M.
MacLean, Madrid, Spain, p.A2817
616 Bi-phasic Expression of MiR-17~92 in PASMC During Hypoxia
Induced by HIF and p53/T. Chen, S. Gonzales, J.B. Huang, Q.
Zhou, H. Yan, S.-H. Sun, G. Zhou, J.U. Raj, Chicago, IL, p.A2818
617 MicroRNA-26b Attenuates Monocrotaline-Induced Pulmonary
Vascular Remodeling Via Targeting Connective Tissue Growth
Factor (CTGF) and Cyclin D1 (CCND1)/R. Wang, G. Sun, Anhui,
China, p.A2819
618 Non-Invasive Sampling of the Airspace Proteome Using HME
Filter Condensate in Mechanically Ventilated Patients with
ARDS/J.B. McNeil, W.H. McDonald, C.M. Shaver, M.A. Warren,
D.W. Russell, L. Ware, J.A. Bastarache, Nashville, TN, p.A2820
619 MicroRNA-185 Mediates Lung Epithelial Cell Death After
Oxidative Stress/D. Zhang, H. Lee, Y. Cao, H.-G. Moon, J.-H.
Hwang, Y. Jin, Boston, MA, p.A2821
620 The Distribution and Efficacy of MiR-29 Mimicry as a Therapy for
Pulmonary Fibrosis Induced by Bleomycin in Mice/G. Yu, R. Wang,
R. Rusty Montgomery, C. Gallant-Behm, A. Gigliotti, T. Woolard, A.
Tzouvelekis, J. Herazo-Maya, K. Sakamoto, Q. Li, G. Deluliis, F.
Ahangari, M. Vukmirovic, N. Aurelien, T. Adams, A. Munivar, L.
Pestano, J. McDonald, N. Kaminski, New Haven, p.A2822
621 The Long Non-Coding RNA FALCOR Directs Lung Epithelial
Development and Repair After Injury by Regulating the
Expression of Foxa2/D.T. Swarr, M. Morley, K. Rathi, S. Zhou, M.
Herriges, E.E. Morrisey, Philadelphia, PA, p.A2823
A109
POSTER DISCUSSION SESSION
REMODELING AND THE MATRIX
2:15 p.m. - 4:15 p.m. MOSCONE CENTER
Room 2014 (West Building, Level 2)
Poster Viewing 2:15-3:00
Discussion 3:00-4:15
Chairing: A.R. West, PhD, Winnipeg, Canada
S.S. An, PhD, Baltimore, MD
A.G. Stewart, PhD, Melbourne, Australia
501 A Lumped Parameter Model of Fiber Recruitment in the
Extracellular Matrix: Implications for the Aging Lung/S. Bou
Jawde, A. Takahashi, B. Suki, Boston, MA, p.A2824
502 Dynamic Changes in Extracellular Matrix Elastin, Laminin, and
Fibronectin During Mouse Lung Development/N. Li, D.
Warburton, W. Shi, Los Angeles, CA, p.A2825
503 Early Impairment of Lung Mechanics in a Murine Model of
Marfan Syndrome/J.J. Uriarte, T. Meirelles, D. Gorbenko Del
Blanco, P.N. Nonaka, N. Campillo, E. Sarri, D. Navajas, G. Egea,
R. Farre, Barcelona, Spain, p.A2826
504 The Integrin Receptor Beta7 Subunit Mediates Lung Fibroblast
Activation: Implications for Airway Remodeling and
Hyperresponsivenss in a Murine Model of Chronic
Allergen-Induced “Asthma”/N. Berkman, T. Obedeyah, M.
Assayag, Jerusalem, Israel, p.A2827
505 Bone Marrow, Adipose and Lung Tissue-Derived Mesenchymal
Stromal Cells Yield Distinct Effects on Lung inflammation and
Remodeling in Experimental Allergic Asthma/S.C. Abreu, M.A.
Antunes, V.C. Branco, F.F. Cruz, B.L. Diaz, M.M. Morales, D.G.
Xisto, P.R.M. Rocco, Rio de Janeiro, Brazil, p.A2828
506 Mechanical Stress-Induced Mast Cell Degranulation Activates
TGFb-1 Signalling Pathway in Pulmonary Fibrosis/C. Shimbori,
P.-S. Bellaye, J. Gauldie, M.R.J. Kolb, Hamilton, Canada, p.A2829
507 Desmoplakin (DSP), a GWAS-Identified Genetic Risk Allele of
IPF, Is a Matrix Stiffness-Regulated Mechanosensitive Gene/J.
Qu, H. Chen, A.V. Estrada, L. Zhu, V.J. Thannickal, Y. Zhou,
Birmingham, AL, p.A2830
508 High Substrate Stiffness Enhances Transforming Growth
Factor Beta Induced Internalization of E-Cadherin in Airway
Epithelial Cells/N. Roy, E. Turner-Brannen, A.R. West, Winnipeg,
Canada, p.A2831
509 Characterization of Extracellular Matrix Remodeling in Stable
COPD Using Serological Biomarkers/J.M.B. Sand, D.J. Leeming,
G. Martinez, A.-K. Midjord, M.A. Karsdal, P. Lange, Herlev,
Denmark, p.A2832
510 Defective Collagen I Remodeling and Contraction Is a Feature
of Asthmatic Airway Fibroblasts/E.T. Osei, L. Mostaco-Guidolin,
S. Hajimohammadi, J. Ullah, F. Shaheen, T.-L. Hackett, Vancouver,
Canada, p.A2833
511 A Digestion-Repair Model of Collagen Fiber Homeostasis and
Its Application to Aging of Lung Tissue/C. Alves, A.D. Araujo, B.
Suki, Boston, MA, p.A2834
512 Human Chymase and the Identification of Integrin a5Ib as
Novel Target for Bronchoconstriction in Asthma/A. Sundaram,
A. Atakilit, C. Chen, A. Khalifeh-Soltani, K. Atabai, D. Sheppard,
San Francisco, CA, p.A2835
513 In vivo Effectiveness of Bitter Taste Receptor Agonists in
Mouse Models of Allergic Asthma/P. Sharma, R. Yi, N. Wang,
D.A. Deshpande, Philadelphia, PA, p.A2836
ATS 2016 • San Francisco