400 WEDNESDAY • MAY 18 3:00 Accelerated Ticking of the Epigenetic Clock in Smokers with and Without COPD/D.L. DeMeo, J.D. Morrow, C.P. Hersh, V. Pinto-Plata, B. Celli, N. Marchetti, G.J. Criner, R. Bueno, G. Washko, E.K. Silverman, W. Qiu, Boston, MA, p.A7479 3:15 Clinical and Genetic Characteristics of Emphysema Distribution Subtypes Identified by Unsupervised Learning Analysis/A. El Boueiz, M.H. Cho, G. Washko, R. San Jose Estepar, D.A. Lynch, J.D. Crapo, E.K. Silverman, D.L. DeMeo, P.J. Castaldi, Boston, MA, p.A7480 D92 MINI SYMPOSIUM REFINING THE EVALUATION AND TREATMENT OF CYSTIC FIBROSIS 1:30 p.m. - 3:30 p.m. MOSCONE CENTER Chairing: M. Jain, MD, Chicago, IL J.L. Taylor-Cousar, MD, Denver, CO S.M. Rowe, MD, Birmingham, AL Featured Speaker Room 2020/2022 (West Building, Level 2) 1:30 The Future of Cystic Fibrosis Care/D.E. Tullis, MD, Toronto, Canada, Oral Presentations 1:45 Association of Sweat Chloride Level with Mortality Varies by Individual Cystic Fibrosis Transmembrane Receptor Genotype/J. Espel, H. Palac, J. Ciolino, J. Cullina, M. Jain, Chicago, IL, p.A7481 2:00 Genetic Variation in CFTR Allele Mutations and ADRB2 Polymorphisms Influence Cardiac Hemodynamic Responses to Albuterol in Individuals with Cystic Fibrosis/E.H. Van Iterson, S.E. Baker, C.M. Wheatley, W.J. Morgan, E.M. Snyder, Rochester, MN, p.A7482 2:15 High Sensitivity C-Reactive Protein in Adult Patients with Cystic Fibrosis Pulmonary Exacerbations/T. Kyaw, M. Callahan, R. Klingsberg, A.H. Alraiyes, F. Kheir, New Orleans, LA, p.A7483 2:30 Prognostic Value of Pulmonary Hypertension in Patients with Cystic Fibrosis/D. Li, F. Wen, L. Gao, Baltimore, MD, p.A7484 2:45 Cystic Fibrosis Related Diabetes: An Audit/O. O’Carroll, D. Hughes, C. McCarthy, D. Smith, C. Gunaratnam, N.G. McElvaney, Dublin, Ireland, p.A7485 3:00 Durable Improvement in Mucociliary Clearance Following a Single Dose of Hypertonic Saline in Cystic Fibrosis/A. Trimble, B. Laube, W. Brown, K.L. Zeman, N. Lechtzin, J. Wu, D. Waltz, W.D. Bennett, S. Donaldson, Chapel Hill, NC, p.A7486 3:15 Relationship Between Throat Culture, Sputum Culture, and Lower Respiratory Tract Culture in Adult Patients with Cystic Fibrosis/D. Seidler, M. Griffin, A.B. Nymon, J. Schwartzman, K. Koeppen, A. Ashare, Lebanon, NH, p.A7487 D93 MINI SYMPOSIUM RESPIRATORY FAILURE: ADVANCED MECHANISTIC INSIGHTS INFORMING TRANSLATION IN ACUTE LUNG INJURY/ARDS 1:30 p.m. - 3:30 p.m. MOSCONE CENTER Chairing: C.C. Dos Santos, MD, Toronto, Canada C. Mikacenic, MD, Seattle, WA J.R. Jacobson, MD, Chicago, IL Oral Presentations Room 3006/3008 (West Building, Level 3) 1:30 An Angiopoietin-2 Genetic Variant Associated with Plasma Angiopoietin-2 Is a Risk Factor for Sepsis-Associated ARDS/N.J. Meyer, J.P. Reilly, T.G. Dunn, J. Abbott, F. Wang, B. Lim, C.A.G. Ittner, B.J. Anderson, M.G.S. Shashaty, J.A. Palakshappa, M.A. Matthay, C.S. Calfee, R. Feng, J.D. Christie, Philadelphia, PA, p.A7488 1:45 A Functional Missense SNP in LRRC16A Contributes to an Improved Prognosis of ARDS Patients Mediated Through Attenuated Platelet Count Decline in ICU/Z. Wang, Y. Wei, P. Tejera, L. Su, E.K. Bajwa, D.C. Christiani, Boston, MA, p.A7489 2:00 ABO Genetic Variation and Acute Respiratory Distress Syndrome Risk in Sepsis/J.P. Reilly, N.J. Meyer, M.G.S. Shashaty, B.J. Anderson, J.A. Palakshappa, C.A.G. Ittner, C.S. Calfee, M. Matthay, Z. Wang, C. Mikacenic, X. Lin, I. Barnett, K. Walley, J.A. Russell, D.C. Christiani, M.M. Wurfel, J.D. Christie, Philadelphia, PA, p.A7490 2:15 Haptoglobin 2:2 Genotype Is Associated with Acute Respiratory Distress Syndrome in Patients with Severe Trauma/H. Nagata, J.B. McNeil, N. Wickersham, C.M. Shaver, N.D. Putz, J.L. Kuck, J.A. Bastarache, L. Ware, Nashville, TN, p.A7491 2:30 Critical Role of Phosphofructokinase-2/Fructose-2,6-Bisphosphatase (PFKFB) 3 in Acute Lung Injury/C. Vohwinkel, N. Burns, J. Kraynik, K.R. Stenmark, H. Eltzschig, Aurora, CO, p.A7492 2:45 RAGE Modulation Influences Lung Injury and AFC: In Vivo and Vitro Studies/R. Blondonnet, J. Audard, J. Lutz, G. Clairefond, C. Belville, D. Bouvier, L. Blanchon, J.-L. Couderc, C. Damon, V. Sapin, J.-M. Constantin, M. Jabaudon, Clermont-Ferrand, France, p.A7493 3:00 Human Mesenchymal Stem Cell Derived Microvesicles Attenuate Acute Lung Injury in Mice Partly Via Transferring Ang-1 mRNA/X.-D. Tang, L. Shi, A. Monsel, X.-Y. Li, H.-L. Zhu, Y.-G. Zhu, J.-M. Qu, Shanghai, China, p.A7494 3:15 Therapeutic Effects of Human Bone Marrow Derived Mesenchymal Stem Cell Microvesicles in an Ex Vivo Perfused Human Lung Injured with Severe E.coli Pneumonia/J. Park, H. Lim, S. Hu, Q. Hao, M.A. Matthay, J.W. Lee, San Francisco, CA, p.A7495 ATS 2016 • San Francisco
WEDNESDAY • MAY 18 401 D94 MINI SYMPOSIUM NON-TUBERCULOUS MYCOBACTERIA: ORGANISM AND HOST 1:30 p.m. - 3:30 p.m. MOSCONE CENTER Chairing: K.P. Fennelly, MD, MPH, Rockville, MD D.E. Griffith, MD, Tyler, TX C. Andrejak, MD, PhD, Amiens, France R. Thomson, MBBS, PhD, Brisbane, Australia Oral Presentations Room 3020/3022 (West Building, Level 3) 1:30 Establishment of the Novel Mouse Models of Human Lung Nontuberculous Mycobacterial Infections/T. Isobe, C. Sano, R. Tanino, Y. Tatano, Y. Mori, M. Nakao, Y. Amano, T. Hotta, M. Hamaguchi, T. Okimoto, Y. Tsubata, S. Hamaguchi, H. Takeyama, Izumo, Japan, p.A7496 1:45 Evaluation of the Airway Microbiome in Non-Tuberculous Mycobacteria/B.D. Scaglione, B.G. Wu, Y. Li, K. Alter, J. Gilani, A. Wang, D. Kamelhar, D. Addrizzo-Harris, L. Segal, New York, NY, p.A7497 2:00 Nitric Oxide Is a Potential Antimicrobial Against Slow- and Fast-Growing Mycobacteria/C. Miller, B. McMullin, C. Deppisch, J. Riethmuller, Vancouver, Canada, p.A7498 2:15 Interleukin 23 / Interleukin 17 Axis Activated by Mycobacterium Avium Complex (MAC) Is Attenuated in Patients with MAC-Lung Disease/C.-C. Shu, J.-Y. Wang, C.-J. Yu, Taipei, Taiwan, p.A7499 2:30 The Association of Peripheral Blood Mucosal-Associated Invariant T-Cell Cells in Patients with COPD and NTM/ R.J. Napier, E. Henkle, K.L. Winthrop, D.M. Lewinsohn, Portland, OR, p.A7500 2:45 Clinical and Environmental Nontuberculous Mycobacteria from Hawaii Demonstrate Varying Degrees of Virulence/J.R. Honda, N.A. Hasan, Y. Zhou, E.D. Chan, Aurora, CO, p.A7501 3:00 Risk of Nontuberculous Mycobacterial Lung Disease Associated with Obstructive Lung Disease in Ontario, Canada/T.K. Marras, M.A. Campitelli, J.C. Kwong, H. Lu, S.K. Brode, A. Marchand-Austin, A.S. Gershon, F.B. Jamieson, Toronto, Canada, p.A7502 3:15 The Risk Of Pulmonary Nontuberculous Mycobacterial Disease Associated with Inhaled Corticosteroid Use/S.K. Brode, M.A. Campitelli, J.C. Kwong, H. Lu, A. Marchand-Austin, A.S. Gershon, F.B. Jamieson, T.K. Marras, Toronto, Canada, p.A7503 D95 MINI SYMPOSIUM DARKNESS ON THE EDGE OF TOWN: NEW MOLECULAR PATHWAYS IN PULMONARY HYPERTENSION 1:30 p.m. - 3:30 p.m. MOSCONE CENTER Chairing: E.F. Spiekerkoetter, MD, Palo Alto, CA B.B. Graham, MD, Aurora, CO Oral Presentations Room 3010/3012 (West Building, Level 3) 1:30 Bone Marrow Endothelial Progenitor Cells Are the Cellular Mediators of Pulmonary Hypertension in the Murine Monocrotaline Injury Model/J. Aliotta, M. Pereira, S. Wen, M.S. Dooner, M. Del Tatto, E. Papa, Y. Cheng, L. Goldberg, P.J. Quesenberry, J. Klinger, Providence, RI, p.A7504 1:45 The Activation of Wnt5a-ROR2 Axis Enhances Endothelial-Pericyte Interaction During Pulmonary Angiogenesis/K. Yuan, M. Orcholski, M. Discipulo, D. Sriram, V. De Jesus Perez, Palo Alto, CA, p.A7505 2:00 HIPPO-Integrin Linked Kinase Crosstalk Regulates Pulmonary Vascular Smooth Muscle Cell Proliferation and Survival in Pulmonary Hypertension/T.V. Kudryashova, D.A. Goncharov, A. Pena, N. Kelly, R.R. Vanderpool, J. Jeff Baust, A. Kobir, W. Shufesky, A.E. Morelli, J. Zhao, K. Ihida-Stansbury, H. DeLisser, R. Tuder, S.M. Kawut, H.H.W. Sillje, S.D. Shapiro, Y. Zhao, E.A. Goncharova, Pittsburgh, PA, p.A7506 2:15 Estrogen Contributes to the Pathogenesis of Experimental Pulmonary Hypertension in Obese Male Mice/K.M. Mair, M. Nilsen, L. Loughlin, M. MacLean, Glasgow, United Kingdom, p.A7507 2:30 Platelet Bioenergetic Screen Reveals Increased Glycolytic Rate in Group 1 Pulmonary Hypertension and Increased Oxygen Consumption in Group 2 Pulmonary Hypertension/Q. Nguyen, C. Corey, M. Reynolds, P. White, R.R. Vanderpool, M.T. Gladwin, M.A. Simon, S. Shiva, Pittsburgh, PA, p.A7508 2:45 HIF2a Deletion in the Pulmonary Endothelial Prevents Hypoxia-Induced Pulmonary Hypertension/A.S. Cowburn, A. Crosby, D. Macias-Gutierrez, M. Southwood, L. Crotty-Alexander, N.W. Morrell, E.R. Chilvers, R.S. Johnson, Cambridge, United Kingdom, p.A7509 3:00 Thrombospondin-1 Deficient Bone Marrow and Pharmacological Inhibition of TGF-b1 Activation Protects Against Schistosomiasis Pulmonary Hypertension/R. Kumar, C. Mickael, B. Kassa, L. Gebreab, D. Koyanangi, L. Sanders, R. Tuder, B.B. Graham, Aurora, CO, p.A7510 3:15 Dasatinib Causes Pulmonary Endothelial Damage and Aggravates Pulmonary Hypertension/C. Phan, A. Huertas, A. Seferian, L. Tu, R. Thuillet, C. Sattler, E.-M. Jutant, M. Le Hiress, Y. Tamura, M.-C. Chaumais, S. Bouchet, B. Maneglier, M. Molimard, P. Rousselot, O. Sitbon, G. Simonneau, D. Montani, M. Humbert, C. Guignabert, Le Plessis-Robins, p.A7511 ATS 2016 • San Francisco WEDNESDAY AFTERNOON
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American Thoracic Society Internati
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TABLE OF CONTENTS ATS 2016 INTERNAT
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2 FRIDAY • MAY 13 PG2A CLINICAL P
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4 FRIDAY • MAY 13 Target Audience
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6 FRIDAY • MAY 13 11:15 Case Disc
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8 FRIDAY • MAY 13 Chairing: H.B.
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10 FRIDAY • MAY 13 10:25 Advanced
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12 FRIDAY • MAY 13 Objectives At
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14 SATURDAY • MAY 14 Abdominal Ul
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16 SATURDAY • MAY 14 PG17 BASIC
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18 SATURDAY • MAY 14 1:05 In What
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20 SATURDAY • MAY 14 10:30 Practi
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22 SATURDAY • MAY 14 Objectives A
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24 SATURDAY • MAY 14 10:10 Is My
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26 SUNDAY • MAY 15 Chairing: D.M.
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28 SUNDAY • MAY 15 Chronic Cough:
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30 SUNDAY • MAY 15 • understand
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32 SUNDAY • MAY 15 Target Audienc
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34 SUNDAY • MAY 15 Oral Presentat
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36 SUNDAY • MAY 15 9:15 Hyperpola
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38 SUNDAY • MAY 15 310 A Smartpho
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40 SUNDAY • MAY 15 103 Immunosupp
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42 SUNDAY • MAY 15 A26 POSTER DIS
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44 SUNDAY • MAY 15 822 Incidence
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46 SUNDAY • MAY 15 519 Maternal H
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48 SUNDAY • MAY 15 P14 P15 P16 P1
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50 SUNDAY • MAY 15 P1545 P1546 Fa
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52 SUNDAY • MAY 15 P60 P61 Facili
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100 SUNDAY • MAY 15 A80-A THEMATI
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102 SUNDAY • MAY 15 Facilitator:
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104 SUNDAY • MAY 15 11:00 a.m.-12
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106 SUNDAY • MAY 15 L1 U.S. FOOD
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108 SUNDAY • MAY 15 12:15 Post-Pr
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110 SUNDAY • MAY 15 MP406 MP407 M
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112 SUNDAY • MAY 15 clinician and
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114 SUNDAY • MAY 15 A86 BASIC •
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116 SUNDAY • MAY 15 Chairing: M.J
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118 SUNDAY • MAY 15 3:30 High Pre
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120 SUNDAY • MAY 15 102 Toll-Like
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122 SUNDAY • MAY 15 A103 POSTER D
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124 SUNDAY • MAY 15 719 Lactate R
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126 SUNDAY • MAY 15 1014 Determin
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128 SUNDAY • MAY 15 611 Plasma Mi
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130 SUNDAY • MAY 15 412 Daytime S
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132 SUNDAY • MAY 15 6:30 p.m. - 8
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134 MONDAY • MAY 16 SS111 SS112 S
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136 MONDAY • MAY 16 Target Audien
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138 MONDAY • MAY 16 9:40 Empoweri
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140 MONDAY • MAY 16 9:28 Endotoxi
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142 MONDAY • MAY 16 10:15 Adaptiv
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144 MONDAY • MAY 16 Oral Presenta
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146 MONDAY • MAY 16 624 Neonatal
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148 MONDAY • MAY 16 118 Compariso
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150 MONDAY • MAY 16 912 Should Pa
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152 MONDAY • MAY 16 1015 Resverat
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154 MONDAY • MAY 16 718 Health Re
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156 MONDAY • MAY 16 P152 Facilita
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158 MONDAY • MAY 16 B35 THEMATIC
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160 MONDAY • MAY 16 P252 P253 P25
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162 MONDAY • MAY 16 P406 P407 P40
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164 MONDAY • MAY 16 P320 Bilatera
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166 MONDAY • MAY 16 B40 THEMATIC
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168 MONDAY • MAY 16 P528 P529 Fac
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170 MONDAY • MAY 16 Facilitator:
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172 MONDAY • MAY 16 B44 THEMATIC
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174 MONDAY • MAY 16 P484 P485 P48
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176 MONDAY • MAY 16 P1161 P1162 P
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178 MONDAY • MAY 16 B48 THEMATIC
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184 MONDAY • MAY 16 Facilitator:
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186 MONDAY • MAY 16 P15 P16 P17 P
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188 MONDAY • MAY 16 Facilitator:
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202 MONDAY • MAY 16 P559 P560 P56
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204 MONDAY • MAY 16 WS3 CLINICAL
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206 MONDAY • MAY 16 Satellite ear
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208 MONDAY • MAY 16 Objectives At
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210 MONDAY • MAY 16 encourage tra
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212 MONDAY • MAY 16 B82 BEHAVIORA
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214 MONDAY • MAY 16 B86 BASIC •
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216 MONDAY • MAY 16 and a number
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218 MONDAY • MAY 16 2:30 Mortalit
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220 MONDAY • MAY 16 3:00 Simultan
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222 MONDAY • MAY 16 525 Clinical
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224 MONDAY • MAY 16 320 Sensitivi
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226 MONDAY • MAY 16 113 COPD Subt
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228 MONDAY • MAY 16 1004 Health C
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230 MONDAY • MAY 16 609 Skeletal
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232 MONDAY • MAY 16 5:00 p.m. - 7
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234 TUESDAY • MAY 17 Chairing: D.
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236 TUESDAY • MAY 17 CLINICAL YEA
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238 TUESDAY • MAY 17 This session
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240 TUESDAY • MAY 17 bronchiectas
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242 TUESDAY • MAY 17 Target Audie
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244 TUESDAY • MAY 17 C18 MINI SYM
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246 TUESDAY • MAY 17 415 Investig
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248 TUESDAY • MAY 17 207 Survival
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250 TUESDAY • MAY 17 906 Phenotyp
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252 TUESDAY • MAY 17 807 The Vali
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254 TUESDAY • MAY 17 515 Roles of
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256 TUESDAY • MAY 17 P383 P384 P3
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258 TUESDAY • MAY 17 Facilitator:
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260 TUESDAY • MAY 17 P199 P200 P2
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262 TUESDAY • MAY 17 P620 Facilit
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274 TUESDAY • MAY 17 P727 P728 P7
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278 TUESDAY • MAY 17 C53 THEMATIC
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298 TUESDAY • MAY 17 C70 THEMATIC
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304 TUESDAY • MAY 17 P973 P974 Fa
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306 TUESDAY • MAY 17 Facilitator:
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308 TUESDAY • MAY 17 C80 THEMATIC
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310 TUESDAY • MAY 17 P98 P99 P100
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312 TUESDAY • MAY 17 • become a
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314 TUESDAY • MAY 17 The topics a
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316 TUESDAY • MAY 17 C85 BASIC
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318 TUESDAY • MAY 17 C89 BASIC
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320 TUESDAY • MAY 17 3:20 Pediatr
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322 TUESDAY • MAY 17 2:45 Long-Te
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324 TUESDAY • MAY 17 918 Sarcoido
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326 TUESDAY • MAY 17 410 Effectiv
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328 TUESDAY • MAY 17 710 Follista
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330 TUESDAY • MAY 17 509 A Mechan
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332 TUESDAY • MAY 17 806 Upper Ai
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334 WEDNESDAY • MAY 18 6:45 Acute
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336 WEDNESDAY • MAY 18 CLINICAL Y
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338 WEDNESDAY • MAY 18 Objectives
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340 WEDNESDAY • MAY 18 D9 BASIC
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342 WEDNESDAY • MAY 18 Oral Prese
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344 WEDNESDAY • MAY 18 10:15 Plas
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346 WEDNESDAY • MAY 18 419 A Nove
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348 WEDNESDAY • MAY 18 216 Simpli
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