Final Program

SUNDAY • MAY 15 87
P1399
P1400
P1401
P1402
Facilitator:
P1403
P1404
P1405
P1406
P1407
P1408
P1409
P1410
Autocrine and Paracrine Nicotinamide
Phosphoribosyltransferase (NAMPT) Activity Promote
Proliferation of Human Pulmonary Artery Smooth Muscle
Cells/J. Chen, S. Singla, J.R. Sysol, S. Comhair, S. Ye, S.C.
Erzurum, R.F. Machado, Chicago, IL, p.A2213
Contribution of Vascular Smooth Muscle ROCK1 to
SUGEN5416/Hypoxia-Induced Pulmonary Hypertension in
Mice/D. Toksoz, R. Warburton, S. Abualkhair, K.C. Penumatsa, I.R.
Preston, U. Kayyali, N.S. Hill, B.L. Fanburg, Boston, MA, p.A2214
Interplay Between IL-13 and Energy Metabolism in Pulmonary
Hypertension/W.-K. Cho, M.O. Kim, C.-M. Lee, J.A. Elias, C.G.
Lee, S.I.S. Rounds, Providence, RI, p.A2215
Osteopontin, a Key Mediator Expressed by Senescent
Pulmonary Vascular Cells and Involved in Pulmonary
Hypertension/E. Marcos, M. Saker, L. Lipskaia, S. Abid, A.
Parpaleix, A. Houssaini, P. Validire, H. Noureddine, L. Boyer, N.
Vienney, C.J. Lesaux, B. Maitre, M. Delcroix, R. Quarck, S. Adnot,
Creteil, France, p.A2216
R.L. Damico, MD, PhD, Baltimore, MD
Abnormal Platelet Phenotype and Function in Pulmonary
Arterial Hypertension/D. Taboada, K. Downes, H. McKinney, J.A.
Guerrero, M.W. Besser, W.N. Erber, K. Freson, N.W. Morrell, W.H.
Ouwehand, J. Pepke-Zaba, Cambridge, United Kingdom, p.A2217
Calpain-Mediated Increase in Sodium-Hydrogen Exchanger
Activity Is Necessary for Pathologic Smooth Muscle
Proliferation in Pulmonary Arterial Hypertension/J. Huetsch, C.
Larrain, L. Shimoda, Baltimore, MD, p.A2218
Genome-Wide Association Study with Interactome-Based
Scoring Identifies Dok4 and Ppp2ca as Novel Candidate Genes
in High-Fat Diet-Induced Pulmonary Hypertension/N. Kelly, J.
Radder, J. Baust, C. Burton, B. Agostini, J. Wood, A. Gregory, A.
Leme, S.D. Shapiro, Pittsburgh, PA, p.A2219
A Novel, Inhaled Prostacyclin Receptor Agonist for the
Treatment of Pulmonary Arterial Hypertension/D.J. Rowlands,
K. Coote, O. Bonneau, K. Choy, N. Duggan, M. Thomas, C.
LeBlanc, S. Charlton, M. Healy, S. Grant, R. Strieter, Cambridge,
MA, p.A2220
Pulmonary Plexiform Arteriopathy in a Murine Model of
Pulmonary Arterial Hypertension: Incidence and Histology/C.
Bardita, M. Patel, M. Pritchard, N. Jeganathan, D. Predescu, S.A.
Predescu, Chicago, IL, p.A2221
Krüppel-Like Factor 4 in Pulmonary Arterial Endothelial Cells
Modulates Smooth Muscle Cell Phenotype/M.A. Shatat, J.
Peachey, A. Hamik, Cleveland, OH, p.A2222
IL-18 Induces p38 MAP Kinase Activation and Adhesion
Capacities in BMPR-II Impaired Pulmonary Microvascular
Endothelial Cells/L. Vengethasamy, R. Gijsbers, A. Michiels, B.
Tielemans, A. Wagenaar, R. Farre Marti, C. Belge, M. Delcroix, R.
Quarck, Leuven, Belgium, p.A2223
A High Throughput Screening Platform Targeting PDLIM5 for
Pulmonary Hypertension/G. Zhou, H. Cheng, T. Chen, M. Tor, D.
Park, J. Huang, N. Khati, Q. Zhou, L. Rong, Chicago, IL, p.A2224
P1411
Facilitator:
P1412
P1413
P1414
P1415
P1416
P1417
P1418
P1419
P1420
Facilitator:
P1421
P1422
Altered Sugar Nucleotide Levels Facilitate Changes in
Glycosylation in IPAH/L. Tian, J.W. Barnes, J. Loftis, J.M. Hiznay,
S.A.A. Comhair, M.E. Lauer, R. Dweik, Cleveland, OH, p.A2225
M.R. Nicolls, MD, Palo Alto, CA
Alpha Globin Expressed by Pulmonary Artery Endothelial Cells
Inhibits NO/sGC/cGMP Signaling in Response to Hypoxia/R.A.
Alvarez, M.P. Miller, S. Hahn, D.A. Goncharov, E.A. Goncharova,
M.T. Gladwin, A. Straub, Pittsburgh, PA, p.A2226
Mechanical Stretch Combines with Adventitial
Fibroblast-Derived Signals to Promote Macrophage Activation
Through Metabolic Reprogramming in Vascular Remodeling/K.
EL Kasmi, C. Myers, A. Flockton, S. Riddle, B.A. McKeon, M. Frid,
K. Brodsky, H. Eltzschig, K.R. Stenmark, Aurora, CO, p.A2227
Administration of Exosomes from Cardiosphere-Derived Cells
in an Animal Model of Pulmonary Arterial Hypertension/R.C.
Middleton, M. Fournier, E. Marban, M.I. Lewis, Los Angeles, CA,
p.A2228
Identification of Candidate GPCRs in Pulmonary Arterial
Hypertension: Role of Purinoceptor 2 (P2Y2) in Pulmonary
Vascular Remodeling/G. Viswanathan, X. Tian, S. Tunaru, P.
Singh, W. Seeger, S. Offermanns, R.T. Schermuly, Giessen,
Germany, p.A2229
Oral CAR Peptide Adjuvant Enhances Sildenafil Therapy for
Pulmonary Arterial Hypertension/D. Mann, X. Yue, J. Sawada,
M. Komatsu, Goleta, CA, p.A2230
CAR Peptide Adjuvant Enables Effective Pulmonary
Hypertension Treatment with Imatinib at Reduced Doses/D.
Mann, X. Yue, J. Sawada, N. Ambalavanan, M. Komatsu, Goleta,
CA, p.A2231
Composition and Structure of the Vascular Basement
Membrane in Pulmonary Hypertension/J. Hoffmann, B. Ghanim,
W. Klepetko, G. Kovacs, H. Olschewski, A. Olschewski, G.
Kwapiszewska, Graz, Austria, p.A2232
Inhibition of L-Type Amino Acid Transporter 1 (LAT-1) Export
of S-Nitrosothiols (SNO) Promotes Red Blood Cell Adhesion to
Endothelial Cells/L.B.M. Dosier, H. Zhu, T.J. McMahon, Durham,
NC, p.A2233
Mas Receptor Activation Increases SOD2 Expression in
Pulmonary Vessels and Decreases Endothelial
Dysfunction/E.J. Carrier, A. Rathinasabapathy, S. Menon, M.R.
Kaplowitz, C.D. Fike, J.D. West, Nashville, TN, p.A2234
S. Bonnet, PhD, Quebec City, Canada
Serotonin Augments Proliferation of Neonatal Calf Pulmonary
Artery Fibroblasts/C.A. Delaney, A. Flockton, E. Nozik-Grayck,
K.R. Stenmark, Aurora, CO, p.A2235
Comparative Analysis of Global Gene Expression Profile in
Mouse Strains After Hypoxic Challenge Either Susceptible to
or Resistant to Chronic Hypoxia-Induced Pulmonary
Hypertension/W. Nichols, N. Dasgupta, P. Hale, T. Le Cras, P.
Pastura, M. Pauciulo, Cincinnati, OH, p.A2236
SUNDAY MORNING
ATS 2016 • San Francisco