Final Program
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TUESDAY • MAY 17 253<br />
1009 Intravascular Delivery of Purified Focal Adhesion Kinase<br />
Protects Against Acute Lung Injury/S.K. Quadri, S. Das, M. Wei,<br />
J. Bhattacharya, New York, NY, p.A4780<br />
1010 Cell-Free Hemoglobin Causes Acute Lung Injury and Increases<br />
Mortality in a Mouse Model of Polymicrobial Sepsis/J.A.<br />
Bastarache, C.M. Shaver, N.D. Putz, J.L. Kuck, M.G. Paul, J.L.<br />
Wynn, L.B. Ware, Nashville, TN, p.A4781<br />
1011 Role of TRPM2 in Sphingolipid-Mediated Radiation-Induced<br />
Lung Injury/Y. Epshtein, H. Wang, A.B. Malik, J. Jacobson,<br />
Chicago, IL, p.A4782<br />
1012 The Importance of Ext1 to Lung Recovery After Pulmonary<br />
Endothelial Glycocalyx Degradation/Y. Yang, S.M. Haeger, J.A.<br />
Ford, J.F. Colbert, K.L. Dailey, R.S. Stearman, F. Zhang, R.J.<br />
Linhardt, E.P. Schmidt, Aurora, CO, p.A4783<br />
1013 Impaired Hypoxic Pulmonary Vasoconstriction After Acute<br />
Lung Injury Is Mediated Through Activation Nuclear Factor of<br />
Activated T-Cells and Epigenetic Mechanisms in Pulmonary<br />
Artery Smooth Muscle Cells/D.R. Fraidenburg, J. Yuan, R.F.<br />
Machado, S.M. Dudek, Chicago, IL, p.A4784<br />
1014 Soluble Epoxide Hydrolase Deficiency or Inhibition Enhances<br />
Murine Hypoxic Pulmonary Vasoconstriction After<br />
Lipopolysaccharide Challenge/M. Wepler, A. Beloiartsev, D.<br />
Panigrahy, D.B. Bloch, F. Ichinose, W.M. Zapol, Boston, MA,<br />
p.A4785<br />
1015 Trefoil Factor 2 Is a Novel Regulator of Vascular Barrier<br />
Dysfunction in Lung Injury/X. Wu, S. Sammani, G.A. Infusino,<br />
S.M. Dudek, J.G.N. Garcia, T. Wang, Tucson, AZ, p.A4786<br />
1016 Inhibition of Murine Pulmonary Microvascular Endothelial Cell<br />
Apoptosis Promotes Repair and Rescues Barrier Function<br />
Under Septic Conditions/S.E. Gill, L. Wang, S. Mehta, London,<br />
Canada, p.A4787<br />
1017 Role of Syndecan-1 in Mechanical Stress-Induced Lung<br />
Endothelial Cell Inflammatory Responses Mediated by Integrin<br />
ß4/W. Chen, R.O. Dull, J.R. Jacobson, Chicago, IL, p.A4788<br />
C29<br />
POSTER DISCUSSION SESSION<br />
PROTECTORS OF THE LUNG: INNATE IMMUNE<br />
RESPONSES IN ACUTE LUNG INJURY<br />
9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />
Room 2014 (West Building, Level 2)<br />
Poster Viewing 9:00-9:45<br />
Discussion 9:45-11:00<br />
Chairing: C.M. Waters, PhD, Memphis, TN<br />
E. Herzog, MD, PhD, New Haven, CT<br />
J.A. Bastarache, MD, Nashville, TN<br />
H. Garn, PhD, Marburg, Germany<br />
R. Paine, MD, Salt Lake City, UT<br />
J. Liu, PhD, Chicago, IL<br />
N.V. Kolliputi, PhD, Tampa, FL<br />
501 IL-36R Blockade Attenuates Lung Injury and Mortality After<br />
H1N1 Influenza Virus Infection in Mice/T. Aoyagi, M.W. Newstead,<br />
X. Zeng, M. Kaku, T.J. Standiford, Ann Arbor, MI, p.A4789<br />
502 Dnase2a Deficiency Suppresses NLRP3 Inflammasome<br />
Activation and Improves the Survival of Mice Subjected to<br />
Cecal Ligation and Puncture Induced Sepsis/K. Nakahira, K.T.<br />
Rooney, S. Hisata, A.M.K. Choi, New York, NY, p.A4790<br />
503 The Two-Pore Potassium Channel TREK-1 Alters<br />
Inflammasome Activation in Alveolar Macrophages/C.N.<br />
Immanuel, J.A. Kennedy, B. Teng, C. Luellen, S.A. Cormier, E.A.<br />
Fitzpatrick, A. Schwingshackl, C.M. Waters, Memphis, TN, p.A4791<br />
504 IL-22 / IL-22 Binding Protein (IL-22ra2) Balance Is Critical for<br />
the Resolution of Influenza Induced Lung Pathology/D.<br />
Pociask, J. Kolls, New Orleans, LA, p.A4792<br />
505 SPLUNC1 Regulates LPS-Induced Innate Immune Activation<br />
and Lung Neutrophilic Inflammation/C.J. Britto, N. Niu, L.E.<br />
Cohn, New Haven, CT, p.A4793<br />
506 The Assembly of NLRP3 Inflammasome Is via PI3K-d Signaling<br />
Pathway in Bronchial Epithelium of HDM-Induced Allergic<br />
Asthma/S.R. Kim, Y.C. Lee, K.B. Lee, H.J. Kim, D.I. Kim, Y.H.<br />
Choe, Jeonju, Korea, Republic of, p.A4794<br />
507 HO-1 Mediates the Cytoprotective Effects of NLRP3 Deficiency<br />
Via Autophagy/Y. Zhang, P.J. Lee, New Haven, CT, p.A4795<br />
508 Toll-Like Receptor 4 Mediates the Protective Effects of VEGF<br />
in Lung Endothelium/Y. Zhang, S. Takyar, P. Shan, P.J. Lee,<br />
New Haven, CT, p.A4796<br />
509 Distinct Effects of Cell-Free Hemoglobin and Heme on Lung<br />
Permeability and Inflammation During Acute Lung Injury/<br />
C.M. Shaver, C.P. Upchurch, D. Janz, B.S. Grove, N.D. Putz, N.<br />
Wickersham, S.I. Dikalov, L. Ware, J.A. Bastarache, Nashville, TN,<br />
p.A4797<br />
510 Midkine Deficiency Attenuates Lipopolysaccharide-Induced<br />
Lung Inflammation in Mice/Y. Tanino, X. Wang, T. Nikaido, M.<br />
Kikuchi, Y. Sato, K. Misa, R. Togawa, Y. Suzuki, M. Uematsu, A.<br />
Fukuhara, S. Sato, J. Saito, H. Yokouchi, M. Munakata, Fukushima,<br />
Japan, p.A4798<br />
511 Lipoteichoic Acid Upregulates Plasminogen Activator<br />
Inhibitor-1 Expression in Human Pleural Mesothelial Cells Via<br />
TLR2/JNK/AP-1 Pathway/K.L. Lee, W.L. Chen, K.S. Lai, C.L.<br />
Chung, Taipei City, Taiwan, p.A4799<br />
512 Effects of Ethanol’s on Pulmonary Expression of Inflammatory<br />
Cytokines and Activation of Anti-Microbial Peptides Via<br />
Vitamin D Pathway/O. Ogunsakin, New Orleans, LA, p.A4800<br />
513 Innate Memory of Airway Epithelial Cells Augments<br />
LPS-Induced Mucous Secretory Response/H.S. Chand, Y.<br />
Mebratu, Y. Tesfaigzi, Albuquerque, NM, p.A4801<br />
514 Aberrant TLR9 Responses in Scleroderma Fibrocytes and<br />
Bleomycin Induced Lung Fibrosis/H. Sun, H. Pan, H. Ding, M.<br />
Gulati, W.H. Fares, P. Adonteng-Boateng, D.A. Carrano, C. Ryu, X.<br />
Peng, C. Dela Cruz, H. Bai, E. Herzog, New Haven, CT, p.A4802<br />
TUESDAY MORNING<br />
ATS 2016 • San Francisco
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