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MONDAY • MAY 16 231<br />
404 Metformin Suppresses Myofibroblast Differentiation by<br />
Inhibition of NOX4-Mediated SMAD Signaling/N. Sato, N.<br />
Takasaka, M. Yoshida, S. Minagawa, J. Araya, N. Saito, K.<br />
Tsubouchi, Y. Kurita, K. Kobayashi, H. Hara, J. Kojima, T. Numata,<br />
Y. Kaneko, K. Nakayama, T. Morikawa, K. Kuwano, Tokyo, Japan,<br />
p.A4534<br />
405 The Proteome Signature of Disease Progression in Idiopathic<br />
Pulmonary Fibrosis/D.N. O’Dwyer, S. Ashley, M. Xia, S. Murray,<br />
E. Grant, E.S. White, K.R. Flaherty, F.J. Martinez, B.B. Moore, Ann<br />
Arbor, MI, p.A4535<br />
406 Alveolar Type II Cell Transplantation Improves Alveolar<br />
Dynamics and Structure in Bleomycin Induced Lung<br />
Fibrosis/G. Gay-Jordi, E. Lopez-Rodriguez, M. Ochs, A.<br />
Serrano-Mollar, Barcelona, Spain, p.A4536<br />
407 Thyroid Hormone as a Novel Therapeutic Agent in Lung<br />
Fibrosis Through Restoration of AECs Mitochondrial<br />
Homeostasis/G. Yu, A. Tzouvelekis, R. Wang, J. Herazo-Maya,<br />
J.P. Castro, G. DeIuliis, T. Woolard, R. Drigo, R. Homer, A.<br />
Srivastava, Y. Gan, M. Graham, X. Liu, P. Mannam, E. Herzog, A.<br />
Antonio C. Bianco, N. Kaminski, New Haven, CT, p.A4537<br />
408 Disease Progression in Idiopathic Pulmonary Fibrosis Is<br />
Associated with an Increased Subpopulation of Resident<br />
Pulmonary Monocyte Like Cells in Bronchoalveolar<br />
Lavage/L.M. Nicol, M. Brittan, J.A. Marwick, A.C. MacKinnon, R.<br />
Mills, P.A. McFarlane, W.A. Wallace, G. Stewart, J. Simpson, A.<br />
Rossi, S.E. Howie, J.T. Murchison, N. Hirani, Edinburgh, United<br />
Kingdom, p.A4538<br />
409 Azithromycin Suppresses TGF-ß-Induced Myofibroblast<br />
Differentiation by Promoting Proteasomal Degradation of NOX4/K.<br />
Tsubouchi, J. Araya, H. Hara, S. Minagawa, N. Saito, N. Sato, M.<br />
Yoshida, Y. Kurita, K. Kobayashi, J. Kojima, T. Numata, Y. Kaneko, K.<br />
Nakayama, T. Morikawa, K. Kuwano, Tokyo, Japan, p.A4539<br />
410 miR338-3p, a Target of Lactate Dehydrogenase, Is Differentially<br />
Regulated in Pulmonary Fibrosis/J.L. Judge, C.F. Woeller, T.H.<br />
Thatcher, R.P. Phipps, P.J. Sime, R.M. Kottmann, Rochester, NY,<br />
p.A4540<br />
411 Self-Assembled Micelle RNAi for Effective and Safe Targeting<br />
of Dysregulated Genes in Pulmonary Fibrosis/P.O. Yoon, J.W.<br />
Park, C.-M. Lee, S.H. Kim, J.-S. Yang, H.-O. Park, K. Lee, Q. Lu,<br />
J.A. Elias, C.G. Lee, Daejeon, Korea, Republic of, p.A4541<br />
412 The Effect of Inhaled Low Dose Carbon Monoxide on<br />
Cytokine/Chemokine Production in Idiopathic Pulmonary<br />
Fibrosis/K.T. Rooney, H.J. Goldberg, G.M. Hunninghake, K. Nakahira, I.I.<br />
Siempos, K.R. Flaherty, F.J. Martinez, J.G.N. Garcia, D.J. Lederer, J.C.<br />
Osorio, G. Raghu, J.A. Villalba, J. Lasky, H.R. Collard, I. Noth, R.F.<br />
Machado, C. Steele, I.O. Rosas, A.M.K. Choi, New York City, NY, p.A4542<br />
413 Pathogenesis of Pulmonary Fibrosis - The Role of Extracellular<br />
Heat Shock Protein-90 (HSP90) in Myofibroblast Differentiation<br />
and Persistence/P.-S. Bellaye, N. Wheildon, C. Shimbori, M.R.J.<br />
Kolb, Hamilton, Canada, p.A4543<br />
414 De Novo Analysis of Human Idiopathic Pulmonary Fibrosis<br />
Lungs Reveals Dysregulated Canonical A-to-G Editing Events<br />
at 3’ UTRs and microRNA Target Sites/R. Soundararajan, T.M.<br />
Stearns, A.L. Griswold, A. Mehta, A. Czachor, J. Fukumoto, R.F.<br />
Lockey, B.L. King, N. Kolliputi, Tampa, FL, p.A4544<br />
415 Effects of Nintedanib and Pirfenidone on Expression and<br />
Maturation of Collagen -a Comprehensive Analysis/L. Knuppel,<br />
Y. Ishikawa, K. Heinzelmann, R. Hatz, J. Behr, H.P. Bachinger, O.<br />
Eickelberg, C.A. Staab-Weijnitz, Munchen, Germany, p.A4545<br />
416 Critical Importance of the ROCK Isoforms ROCK1 and ROCK2<br />
for Vascular Leak and Dendritic Cell Recruitment in Pulmonary<br />
Fibrosis/R.S. Knipe, C.K. Probst, J.W. Griffith, B.S. Shea, J.K.<br />
Liao, A.M. Tager, Boston, MA, p.A4546<br />
417 MUC5B And TOLLIP Variants: Association with Disease<br />
Progression And Survival in an IPF Cohort/C. Stock, M. Bonini,<br />
S. Kingston, G.E. Lindahl, A.-M. Russell, P.L. Molyneaux, P.<br />
Saunders, M.A. Kokosi, P. Sestini, A.U. Wells, T.M. Maher, E.A.<br />
Renzoni, London, United Kingdom, p.A4547<br />
418 Oral Treatment with PBI-4050 Reduces Serum and Lung<br />
Anti-Inflammatory/Fibrotic Biomarkers/L. Gagnon, B. Grouix, M.<br />
Tremblay, A. Laverdure, L. Gervais, F. Sarra-Bournet, L. Geerts, K.<br />
Hince, M.-P. Cloutier, M. Leduc, S. Abbott, J.-S. Duceppe, B.<br />
Zacharie, P. Laurin, Laval, Canada, p.A4548<br />
419 Amelioration of Pulmonary Fibrosis by Targeting the Unfolded<br />
Protein Response/M. Thamsen, B.J. Backes, F.R. Papa, San<br />
Francisco, CA, p.A4549<br />
420 MUC5B Promoter Polymorphism rs35705950 Enhances the<br />
Risk of Asymptomatic Fibrotic Interstitial Lung Disease/S.K.<br />
Mathai, A.D. Walts, J. Powers, D.A. Lynch, J.H. Chung, K. Smith,<br />
J. Woodward, J. Loyd, K.K. Brown, M.P. Steele, M.I. Schwarz, T.<br />
Fingerlin, I.V. Yang, D.A. Schwartz, Aurora, CO, p.A4550<br />
421 Treatment with a Selective KCa3.1 Ion Channel-Inhibitor<br />
Attenuates Established Pulmonary Fibrosis in a Segmental<br />
Bleomycin Challenge Model in Sheep/L. Organ, E.<br />
Koumoundouros, B. Bacci, C. Samuel, W. Kimpton, K. Snibson,<br />
Parkville, Australia, p.A4551<br />
422 Administration of Sphingosine Kinase 1 Inhibitor<br />
Post-Bleomycin Challenge Attenuates Bleomycin-Induced<br />
Pulmonary Fibrosis in Mice: Role of YAP1/L.S. Huang, V.<br />
Natarajan, Chicago, IL, p.A4552<br />
423 Non Circulating Pulmonary Resident Memory T Cells Can Be<br />
Identified And Demonstrate Activated Phenotypes in Idiopathic<br />
Pulmonary Fibrosis/C. Bonham, C.L. Hrusch, M. Jaffery, A.<br />
Adegunsoye, K. Blaine, M.E. Strek, I. Noth, A.I. Sperling, Chicago,<br />
IL, p.A4553<br />
424 XBP1 Deficiency in Type II Alveolar Epithelial Cells Protects<br />
Against Lung Fibrosis/J. Brands, M. Bueno, M. Rojas, A.L. Mora,<br />
Pittsburgh, PA, p.A4554<br />
425 Targeting Fibroblastoid-Like Cells by Drug Loaded Engineered<br />
Gold Nanoparticles as Novel Approach for ILD-SSc<br />
Treatment/F. Meloni, E. Cova, S. Inghilleri, V. Codullo, L. Pandolfi,<br />
D. Piloni, M. Colombo, M. Morosini, V. Barzon, S. Magni, D.<br />
Prosperi, C. Montecucco, Pavia, Italy, p.A4555<br />
MONDAY AFTERNOON<br />
ATS 2016 • San Francisco