344 WEDNESDAY • MAY 18 10:15 Plasma Metabolomics Analysis Identifies Candidate Biomarkers of Flavoring-Induced Bronchiolitis Obliterans/M.W. Foster, J.W. Thompson, D.M. Brass, M.A. Moseley, D.L. Morgan, S.M. Palmer, Durham, NC, p.A6452 10:30 Metabolomic Profiling of Childhood Asthma Severity in a Costa-Rican Population: Insights into Disease Pathogenesis/R.S. Kelly, A. Dahlin, A.C. Wu, M. McGeachie, D.C. Croteau-Chonka, S.T. Weiss, J. Lasky-Su, Boston, MA, p.A6453 10:45 Varying Effects of PM2.5, Genetic and Epigenetic Variations in iNOS Promoter on FeNO in Children/Y. Zhang, M. Salam, K. Berhane, S. Eckel, E. Rappaport, W. Linn, R. Habre, T. Bastain, F. Gilliland, Salt Lake City, UT, p.A6454 D18 MINI SYMPOSIUM CYSTIC FIBROSIS AND PRIMARY CILIARY DYSKINESIA: TWO SIDES OF THE SAME COIN? 9:00 a.m. - 11:00 a.m. MOSCONE CENTER Chairing: A.J. Shapiro, MD, Montreal, Canada D. Hayes, MD, Columbus, OH Oral Presentations Room 3007/3009 (West Building, Level 3) 9:00 Respiratory Microbiology in Primary Ciliary Dyskinesia: Comparisons to a Pediatric Cystic Fibrosis Cohort/M.C. Tracy, J.M. Zirbes, C. Hernandez, D.N. Cornfield, C.E. Milla, Palo Alto, CA, p.A6455 9:15 Comparison of the Microbiota of the Airway in Children with Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis/R.J. Green, S. Vosloo, R. Masekela, S. De Beer, F. Venter, Pretoria, South Africa, p.A6456 9:30 A Comparison of Anaerobic to Aerobic Power Ratio in Children with Primary Ciliary Dyskinesia and Healthy Controls/S. Simsek, D. Inal-Ince, A. Cakmak, E. Calik-Kutukcu, M. Saglam, N. Vardar-Yagli, N. Emiralioglu, H.U. Ozcelik, H. Sonbahar-Ulu, C. Bozdemir-Ozel, H. Arikan, N. Kiper, Ankara, Turkey, p.A6457 9:45 In Vivo Cystic Fibrosis (CF) Nasal Epithelial Transcriptomic Studies Reveal non-CFTR Differential Gene Expression Associated with CF Lung Disease Severity/D. Polineni, H. Dang, R.G. Pace, J.R. Stonebraker, X.G. Guo, L.C. Jones, C.R. Esther, M.P. Boyle, J.F. Chmiel, P.R. Durie, P.J. Gallins, F.A. Wright, W.K. O’Neal, M. Knowles, Kansas City, KS, p.A6458 10:00 The Influence of Secondhand Smoke Exposure on Arachidonic Acid Metabolism and Outcomes in Infants and Young Children with Cystic Fibrosis/B.T. Kopp, L.K. Rogers, A. Mejias, D. Hayes, Jr., D. Tumin, F. Woodley, R. Thompson, J. Groner, Columbus, OH, p.A6459 10:15 Minorities with Cystic Fibrosis Are Underrepresented in Pharmacology Clinical Trials/M.E. McGarry, S.A. McColley, San Francisco, CA, p.A6460 10:30 Age-Related Survival Disparity Associated with Lung Transplantation in Cystic Fibrosis: An International Study/ D. Hayes, Jr., A.R. Glanville, D. McGiffin, J.D. Tobias, D. Tumin, Columbus, OH, p.A6461 Featured Speaker 10:45 Contrasting the CF and PCD Phenotypes/S.D. Davis, MD, Indianapolis, IN, D19 MINI SYMPOSIUM CLINICAL STUDIES IN PH 9:00 a.m. - 11:00 a.m. MOSCONE CENTER Chairing: R.T. Zamanian, MD, Stanford, CA R. Souza, MD, PhD, Sao Paulo, Brazil I. Lang, MD, Vienna, Austria Oral Presentations Room 3010/3012 (West Building, Level 3) 9:00 Comprehensive Characterization of Insulin Resistance and Its Association with Ventricular Function in Pulmonary Arterial Hypertension/R.E. Wells, M. Cuttica, R. Dash, F. Abbasi, M. Van De Veerdonk, I.R. Preston, A.R. Hemnes, A.J. Sweatt, M. Gomberg-Maitland, R.T. Zamanian, Stanford, CA, p.A6462 9:15 Sarcoidosis-Associated Pulmonary Hypertension in the Modern PAH-Targeted Therapy Era: Experience from the French Registry/A. Boucly, H. Nunes, X. Jais, V. Cottin, A. Tazi, O. Sanchez, G. Prevot, M. Reynaud Gaubert, C. Dromer, C. Viacroze, D. Horeau Langlard, C. Pison, E. Bergot, D. Montani, G. Simonneau, M. Humbert, O. Sitbon, L. Savale, Le Kremlin Bicêtre, France, p.A6463 9:30 Serial Vasoreactivity Reassessment Is a Prognostic Tool in Pulmonary Arterial Hypertension/A.J. Sweatt, E.F. Spiekerkoetter, A. Hsi, Y. Sung, V. De Jesus Perez, K. Kudelko, R.T. Zamanian, Stanford, CA, p.A6464 9:45 Extended Evaluation of emPHasis-10 Quality of Life Questionnaire in PH/I. Smith, C. Billings, D. Kiely, J. Yorke, I. Armstrong, Sheffield, United Kingdom, p.A6465 10:00 Targeting the Prostacyclin Pathway in the Treatment of Connective Tissue Disease Associated Pulmonary Arterial Hypertension (PAH): Insights from the Randomized Controlled GRIPHON Trial with Selexipag/S.P. Gaine, R.N. Channick, L. Di Scala, N. Galie, H.-A. Ghofrani, M.M. Hoeper, I. Lang, V. McLaughlin, R. Preiss, L.J. Rubin, G. Simonneau, O. Sitbon, V. Tapson, K.M. Chin, Dublin, Ireland, p.A6466 10:15 Comparative Effectiveness of Pharmacological Interventions for Pulmonary Arterial Hypertension: A Systematic Review and Network Meta-Analysis/S. Jain, R. Khera, Z. Wang, M.H. Murad, A. Blevins, G.A. Schmidt, S. Singh, A.K. Gerke, Iowa City, IA, p.A6467 10:30 A Randomized Open Label Study Comparing First-Line Treatment with Bosentan or Sildenafil in Chronic Thromboembolic Pulmonary Hypertension/E. Gotti, M. Palazzini, A. Manes, C. Bachetti, G. Mazzanti, A. Rinaldi, F. Dardi, A. Albini, E. Monti, S. Fukui, D. Guarino, N. Galie, Bologna, Italy, p.A6468 ATS 2016 • San Francisco
WEDNESDAY • MAY 18 345 10:45 Comparing Patient-Reported Outcomes to Functional, Hemodynamic, Echocardiographic, and Cardiac MRI Parameters in Scleroderma-Associated Pulmonary Arterial Hypertension/R. Khair, T. Kolb, R.L. Damico, P.M. Hassoun, R.T. Zamanian, R. Tedford, T. Housten Harris, T. Sato, E. Pullins, C. Corona-Villalobos, S.L. Zimmerman, O. Minai, F. Torres, R.E. Girgis, K.M. Chin, S.C. Mathai, Baltimore, MD, p.A6469 D21 POSTER DISCUSSION SESSION ASTHMA TREATMENT: GLUCOCORTICOIDS, BIOLOGICALS AND BEYOND 9:00 a.m. - 11:00 a.m. MOSCONE CENTER Room 2010/2012 (West Building, Level 2) Poster Viewing 9:00-9:45 Discussion 9:45-11:00 Chairing: S.E. Wenzel, MD, Pittsburgh, PA L.E. Cohn, MD, New Haven, CT N.J. Kenyon, MD, Sacramento, CA 401 Effect of Mepolizumab in Severe Eosinophilic Asthma Patients Eligible for Omalizumab Treatment/F.C. Albers, R. Price, S. Yancey, E. Bradford, Research Triangle Park, NC, p.A6470 402 Burden of Disease in Severe Asthma Mepolizumab Population Stratified by Blood Eosinophil Count/E. Bradford, R. Follows, R. Price, S. Yancey, Research Triangle Park, NC, p.A6471 403 Utility of Serum Periostin and Free IgE Levels in Evaluating Responsiveness to Omalizumab in Patients with Severe Asthma/T. Tajiri, H. Matsumoto, Y. Gon, R. Ito, S. Hashimoto, K. Izuhara, M. Suzukawa, K. Ohta, J. Ono, S. Ohta, I. Ito, T. Oguma, H. Inoue, T. Iwata, T. Nagasaki, Y. Kanemitsu, A. Niimi, M. Mishima, Kyoto, Japan, p.A6472 404 Baseline IgE Levels as a Marker of Type 2 Asthma Among Patients Enrolled in the Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab (PROSPERO)/B.E. Chipps, W.W. Busse, A.T. Luskin, R.S. Zeiger, B. Trzaskoma, N.M. Griffin, T.A. Omachi, T.B. Casale, Sacramento, CA, p.A6473 405 Omalizumab - Response in Patients with Severe Allergic Asthma in a Real Life Setting/L. Zierau, E.S. Walsted, V. Backer, Copenhagen, Denmark, p.A6474 406 Regulating Goblet Cell Formation and Mucus Production with Inhaled Sam Pointed Domain Containing ETS Transcription Factor (SPDEF) Antisense Oligonucleotides/J. Crosby, C. Zhao, D. Bai, M. McCaleb, S. Guo, B.P. Monia, Carlsbad, CA, p.A6475 407 A Randomized, Double-Blinded, Placebo-Controlled, Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of XmAbr7195/A. Gershman, R. Goldwater, P. Foster, San Diego, CA, p.A6476 408 L-Arginine and Glucagon-Like Peptide 1, a Novel Pathway to Asthma Control/D.-V. Nguyen, A.L. Linderholm, L. Franzi, N.J. Kenyon, Sacramento, CA, p.A6477 409 The Effect of the 15-Lipoxygenase 1 (15LO1) Inhibitor BLX2477 on IL-13-Induced Periostin mRNA Expression in Human Airway Epithelial Cells (HAECs)/Y. Minami, E.B. Etling, V.B. O’Donnell, E.B. Yecies, J.B. Trudeau, H.E. Claesson, J. Zhao, S.E. Wenzel, Pittsburgh, PA, p.A6478 410 Inhibition of Asthma Phenotype Through Aerobic Exercise: Involvement of P2X7 Receptor and CD73 Signaling in Airway Epithelium and in Peribronchial Leukocytes/R.P. Vieira, M.C. De Oliveira Junior, A.R. Almeida-Oliveira, J.C.J. Aquino-Junior, A.S. Andrade-Sousa, E. Assumpcao-Neto, A. Aparecida-Brito, N.C. Rigonato-Oliveira, A.S. Renno, M.A.R. Brandao-Rangel, A.P.L. Oliveira, Sao Paulo, Brazil, p.A6479 411 Aerobic Exercise Reduces Asthma Phenotype Through Modulation of SOCS-JAK-STAT Signaling/R.P. Vieira, A.R. Almeida-Oliveira, J.C.J. Aquino-Junior, M.C. Oliveira-Junior, A.S. Andrade-Sousa, E. Assumpcao-Neto, A. Aparecida-Brito, N.C. Rigonato-Oliveira, A. Silva-Renno, M.A.R. Brandao-Rangel, A.P.L. Oliveira, Sao Paulo, Brazil, p.A6480 412 Anti-Inflammatory Effect of an Eicosapentaenoic Acid Metabolite on Airway Inflammation in a Murine Model of Ovalbumin-Induced Asthma/T. Mochimaru, K. Fukunaga, J. Miyata, M. Matsusaka, K. Masaki, H. Kabata, Y. Suzuki, Y. Isobe, M. Arita, T. Betsuyaku, Tokyo, Japan, p.A6481 413 Selective Targeting of STAT6 at Antigen Priming Reduces OX40L and TH2-Biased Airway Inflammatory Responses/S. Lee, J. Shan, B.T. Srinivasa, M. Jin, E.D. Fixman, Montrea, Canada, p.A6482 414 Pre-Clinical Evaluation of a Potent Janus Kinase (JAK) Inhibitor Designed for Topical Delivery in Severe Asthma/H.-H. Lee, M.A. Gil, J. Woodhouse, M. Caniga, A. Byford, R. McLeod, Y. Jia, R. Fernandes, J. Naber, D. Witter, M. Cicmil, M. Salmon, Boston, MA, p.A6483 415 Developing FOXM1 Inhibitors to Suppress Goblet Cell Metaplasia and Airways Hyperresponsiveness/V. Kalinichenko, L. Sun, X. Ren, I.-C. Wang, A. Pradhan, Y. Zhang, B. Han, J.A. Whitsett, T.V. Kalin, Cincinnati, OH, p.A6484 416 A Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Oral Azithromycin (500 Mg OD) as a Supplement to Standard Care for Adult Patients with Acute Exacerbations of Asthma (the AZALEA Trial)/S.L. Johnston, M. Szigeti, M. Cross, C.E. Brightling, R. Chaudhuri, T. Harrison, A.H. Mansur, L. Robinson, Z. Sattar, D.J. Jackson, P. Mallia, E.H.C. Wong, C. Corrigan, B. Higgins, P. Ind, D. Singh, N.C. Thomson, D. Ashby, A. Chauhan, London, United Kingdom, p.A6485 417 Effect of Dupilumab on FEV1 and Severe Exacerbations in Patients with Uncontrolled Persistent Asthma: A Subgroup Analysis Defined According to Early-Onset and Late-Onset Asthma/S.F. Weinstein, L.B. Ford, B. Zhang, G. Pirozzi, H. Staudinger, R.R. Evans, N.M.H. Graham, M. Louis-Tisserand, A. Teper, Huntington Beach, CA, p.A6486 418 Roflumilast Ameliorates Airway Hyper-Responsiveness Caused by Diet-Induced Obesity in a Murine Model/H.J. Park, J.-H. Lee, Y.H. Park, H. Han, D.W. Sim, K.H. Park, J.-W. Park, Seoul, Korea, Republic of, p.A6487 WEDNESDAY MORNING ATS 2016 • San Francisco
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American Thoracic Society Internati
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TABLE OF CONTENTS ATS 2016 INTERNAT
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2 FRIDAY • MAY 13 PG2A CLINICAL P
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4 FRIDAY • MAY 13 Target Audience
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6 FRIDAY • MAY 13 11:15 Case Disc
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8 FRIDAY • MAY 13 Chairing: H.B.
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10 FRIDAY • MAY 13 10:25 Advanced
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14 SATURDAY • MAY 14 Abdominal Ul
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16 SATURDAY • MAY 14 PG17 BASIC
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18 SATURDAY • MAY 14 1:05 In What
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20 SATURDAY • MAY 14 10:30 Practi
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26 SUNDAY • MAY 15 Chairing: D.M.
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28 SUNDAY • MAY 15 Chronic Cough:
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30 SUNDAY • MAY 15 • understand
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32 SUNDAY • MAY 15 Target Audienc
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34 SUNDAY • MAY 15 Oral Presentat
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36 SUNDAY • MAY 15 9:15 Hyperpola
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38 SUNDAY • MAY 15 310 A Smartpho
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40 SUNDAY • MAY 15 103 Immunosupp
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42 SUNDAY • MAY 15 A26 POSTER DIS
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44 SUNDAY • MAY 15 822 Incidence
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46 SUNDAY • MAY 15 519 Maternal H
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106 SUNDAY • MAY 15 L1 U.S. FOOD
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110 SUNDAY • MAY 15 MP406 MP407 M
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116 SUNDAY • MAY 15 Chairing: M.J
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118 SUNDAY • MAY 15 3:30 High Pre
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120 SUNDAY • MAY 15 102 Toll-Like
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122 SUNDAY • MAY 15 A103 POSTER D
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124 SUNDAY • MAY 15 719 Lactate R
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126 SUNDAY • MAY 15 1014 Determin
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128 SUNDAY • MAY 15 611 Plasma Mi
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130 SUNDAY • MAY 15 412 Daytime S
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132 SUNDAY • MAY 15 6:30 p.m. - 8
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134 MONDAY • MAY 16 SS111 SS112 S
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140 MONDAY • MAY 16 9:28 Endotoxi
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142 MONDAY • MAY 16 10:15 Adaptiv
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144 MONDAY • MAY 16 Oral Presenta
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146 MONDAY • MAY 16 624 Neonatal
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148 MONDAY • MAY 16 118 Compariso
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150 MONDAY • MAY 16 912 Should Pa
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152 MONDAY • MAY 16 1015 Resverat
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154 MONDAY • MAY 16 718 Health Re
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228 MONDAY • MAY 16 1004 Health C
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230 MONDAY • MAY 16 609 Skeletal
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232 MONDAY • MAY 16 5:00 p.m. - 7
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234 TUESDAY • MAY 17 Chairing: D.
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236 TUESDAY • MAY 17 CLINICAL YEA
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238 TUESDAY • MAY 17 This session
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240 TUESDAY • MAY 17 bronchiectas
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242 TUESDAY • MAY 17 Target Audie
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244 TUESDAY • MAY 17 C18 MINI SYM
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246 TUESDAY • MAY 17 415 Investig
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248 TUESDAY • MAY 17 207 Survival
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