Final Program

SATURDAY • MAY 14 15
PG16
BASIC • CLINICAL • TRANSLATIONAL
POSTGRADUATE COURSE
CME Credits Available: 7.5
HETEROGENEITY AND PLASTICITY OF LUNG
MACROPHAGES: TOWARDS PRECISION MEDICINE
Pre-registration and additional fees required. Continental breakfast and
box lunch included. Attendance is limited.
Member: $350 In-Training Member: $200
Non-Member: $425 In-Training Non-Member: $300
Registrants must bring a laptop to the
course to view the course material.
Assemblies on Allergy, Immunology and Inflammation; Clinical
Problems; Critical Care; Environmental, Occupational and Population
Health; Microbiology, Tuberculosis and Pulmonary Infections;
Pediatrics; Pulmonary Circulation; Respiratory Cell and Molecular
Biology; Respiratory Structure and Function; Thoracic Oncology
8:00 a.m. - 4:00 p.m. MOSCONE CENTER
Room 2022 (West Building, Level 2)
Target Audience
Lung health care providers, scientists and investigators interested or involved in
basic and/or translational research related to lung biology, immunology, pathology,
physiology, mechanisms and biologic phenotypes of human lung disease;
research and care providers engaged in pulmonary and critical care medicine.
Objectives
At the conclusion of this session, the participant will be able to:
• understand fundamental principles of macrophage origins, nomenclature,
markers/phenotypes, functions in lung immunity and tissue homeostasis;
• learn about novel state of art technologies that can be utilized to study human
lung macrophages at the molecular (genome, transcriptome, epigenetics,
bioinformatics, single cell analysis), and cellular (advanced imaging and
molecular phenotyping methods, single cell analysis) levels and how information
obtained using these methods can be used to better understand the role of
macrophages in the pathogenesis of human lung diseases;
• understand how to translate the novel knowledge about lung macrophage
heterogeneity, plasticity, and polarization into clinically relevant precision
medicine approaches to better prevent, diagnose and treat human lung
diseases in a personalized manner.
This postgraduate course is focused on:(1)recent advances in understanding of the
origin, phenotypic and functional diversity, plasticity, polarization programs and local
homeostasis of lung macrophages;(2)pathologic programming of macrophages in
human lung disease;(3)the role of macrophages in lung host defense, inflammation
and regeneration;(4)state of art personalized analysis of human lung macrophage
biology; and(5)macrophage-based precision medicines for human lung disease.
Chairing: R. Shaykhiev, MD, PhD, New York, NY
A. Haczku, MD, PhD, Davis, CA
D. Singh, MD, Manchester, United Kingdom
8:00 Introduction
A. Haczku, MD, PhD, Davis, CA
8:10 Keynote Lecture: Identity and Self-Renewal of Tissue
Macrophages
M.H. Sieweke, PhD,Marseille, France
8:40 Unique Origins and Differentiation Pathways of Lung
Macrophages
M. Kopf, PhD, Zurich, Switzerland
9:10 Macrophage Heterogeneity in the Human Lung
C. Jakubzick, PhD, Denver, CO
9:35 Live Imaging of Macrophage - Epithelium Interactions in the
Lung
J. Bhattacharya, MD, DPhil, New York, NY
10:00 Break
10:15 Transcriptional Programming of Human Macrophages
J. Schultze, MD, Bonn, Germany
10:40 Human Alveolar Macrophage Polarization: M1, M2 and Beyond
R. Shaykhiev, MD, PhD, New York, NY
11:00 Personalized Macrophage Responses to Disease-Modifying
Therapies in Asthma and COPD
D. Singh, MD, Manchester, United Kingdom
11:20 Defective Macrophage Phagocytosis of Bacteria in Chronic
Lung Disease
L. Donnelly, PhD, London, United Kingdom
11:45 Luncheon Sessions: Alveolar Macrophages in Host-Microbe
Interactions and Lung Homeostasis
2:00 Break
Alveolar Macrophage as a Niche for Mycobacteria and HIV
D. Russell, PhD, Ithaca, NY
How Respiratory Viruses Drive Alternative Macrophage
Polarization in Lung Disease
M.J. Holtzman, MD, St. Louis, MO
Lung Macrophages, Th2 Inflammation and Pulmonary Fibrosis
T. Wynn, PhD, Bethesda, MD
The Role of Polarized Macrophages in Lung Regeneration
J.R. Rock, PhD, San Francisco, CA
Alveolar Macrophage-Based Precision Therapy for Human
Lung Disease
B.C. Trapnell, MD, Cincinnati, OH
2:15 “Lab Meeting”
R. Shaykhiev, MD, PhD, New York, NY
A. Haczku, MD, PhD, Davis, CA
D. Singh, MD, Manchester, United Kingdom
M. Kopf, PhD, Zurich, Switzerland
C. Jakubzick, PhD, Denver, CO
J. Bhattacharya, MD, DPhil, New York, NY
J. Schultze, MD, Bonn Germany
L. Donnelly, PhD, London, United Kingdom
D. Russell, PhD, Ithaca, NY
M.J. Holtzman, St. Louis, MO
T. Wynn, PhD, Bethesda, MD
J.R. Rock, PhD, San Francisco, CA
B.C. Trapnell, MD, Cincinnati, OH
This session and the International Conference are supported by an educational grant from
AstraZeneca LP.
All CME sessions have been planned and implemented in accordance with the Essential
Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME)
and are free of the control of commercial interests.
SATURDAY
ATS 2016 • San Francisco