Final Program

8 FRIDAY • MAY 13
Chairing: H.B. Panitch, MD, Philadelphia, PA
J.L. Allen, MD, Philadelphia, PA
8:00 Lung Development and Neonatal Predisposition to Respiratory
Failure
M.J. Wallace, PhD, Melbourne, Australia
8:35 Acute and Chronic Neonatal Respiratory Failure
L.D. Nelin, MD, Columbus, OH
9:10 The Physiology of Pediatric Ventilator-Induced Lung Injury
M.C.J. Kneyber, MD, PhD, Groningen, Netherlands
9:45 Break
9:55 High Frequency Oscillatory Ventilation
J.L. Allen, MD, Philadelphia, PA
10:30 Lung Mechanics and Respiratory Failure
J.P. Needleman, MD, Brooklyn, NY
11:05 Ventilator Graphics
H.B. Panitch, MD, Philadelphia, PA
11:40 LUNCH
12:20 Cardiopulmonary Interactions
S. Lakshminrusimha, MD, Buffalo, NY
12:55 Positive and Negative Pressure Ventilation
G. Kurland, MD, Pittsburgh, PA
1:30 Respiratory Muscles, Failure and Ventilator-Induced
Diaphragm Injury
G.J. Redding, MD, Seattle, WA
2:05 Break
2:15 Weaning in Pediatric Acute Respiratory Failure
S. Venkataraman, MD, Pittsburgh, PA
2:50 Weaning and Chronic Respiratory Failure
T.G. Keens, MD, Los Angeles, CA
3:25 Respiratory Muscle Weakness, Posture and Pulmonary
Rehabilitation
M. Massery, PT, DPT, DSc, Glenview, IL
PG10
BASIC • CLINICAL • TRANSLATIONAL
POSTGRADUATE COURSE
CME Credits Available: 7.25
AIRWAY REMODELING IN HUMAN LUNG DISEASE:
A BIG LAB MEETING 2016
Pre-registration and additional fees required. Continental breakfast and
box lunch included. Attendance is limited.
Member: $350 In-Training Member: $200
Non-Member: $425 In-Training Non-Member: $300
Registrants must bring a laptop to the
course to view the course material.
Assemblies on Respiratory Cell and Molecular Biology; Allergy,
Immunology and Inflammation; Clinical Problems; Critical Care;
Environmental, Occupational and Population Health; Microbiology,
Tuberculosis and Pulmonary Infections; Pediatrics; Pulmonary
Circulation; Pulmonary Rehabilitation; Respiratory Structure and
Function; Sleep and Respiratory Neurobiology; Thoracic Oncology
8:00 a.m. - 4:00 p.m. MOSCONE CENTER
Room 2022 (West Building, Level 2)
Target Audience
Lung health care providers, clinical and research fellow, investigators interested
or involved in basic, translational and clinical research related to airway biology
and pathogenesis of chronic lung diseases, research and care providers
engaged in pulmonary and critical care medicine.
Objectives
At the conclusion of this session, the participant will be able to:
• understand fundamental principles, heterogeneous phenotypes and specific
mechanisms of airway remodeling in chronic human lung diseases; and
how different cell types in the human airways interact with each other during
the development of disease-associated remodeling phenotypes.
• learn about advanced state of art methods and technologies to model and
study human airway remodeling using patient derived samples.
• implement current knowledge about airway remodeling in everyday
research and understand how to translate the novel knowledge about
complex mechanisms and phenotypes of airway remodeling into clinically
relevant precision medicine approaches to better prevent, diagnose and
treat human lung disease in a personalized manner.
This course will have an innovative, “lab meeting” format, first successfully
introduced at the ATS International Conference in 2015 by Dr. Shaykhiev and
colleagues. As compared to the prior “big lab meeting” postgraduate course
(PG25), which was focused on airway epithelium, the specific theme of the
current session - airway remodeling - is broader and more multidisciplinary and
translational in nature. The course will provide discussion of recent
advancements in understanding of the contributions of and interactions among
various tissue components (epithelium, fibroblasts, extracellular matrix, smooth
muscle cells, vasculature, and innate immune cells) to airway remodeling in
human chronic lung diseases. Special emphasis will be made on personalized
approaches to study human airway remodeling and novel precision medicine
approaches to prevent and treat lung diseases characterized by airway
remodeling.
Chairing: R. Shaykhiev, MD, PhD, New York, NY
M. Konigshoff, MD, PhD, Munich, Germany
R. Freishtat, MD, MPH, Washington, DC
8:00 Airway Remodeling: Introduction to a Big Lab Meeting 2016
M. Konigshoff, MD, PhD, Munich, Germany
8:10 Keynote Lecture: The Many Faces of Airway Remodeling in
Lung Disease
J.C. Hogg, MD, PhD, Vancouver, Canada
8:40 Basal Stem Cells and Airway Remodeling in COPD
R. Shaykhiev, MD, PhD, New York, NY
9:00 Cellular Origins of Airway Remodeling in Asthma
T. Hackett, PhD, Vancouver, Canada
9:20 Airway Regeneration and Remodeling in Cystic Fibrosis
C. Coraux, PhD, Reims, France
9:40 Patient-Derived Models of Airway Remodeling
S.H. Randell, PhD, Chapel Hill, NC
10:00 Break
ATS 2016 • San Francisco