Final Program
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MONDAY • MAY 16 155<br />
321 Folylpoly-g-Glutamate Synthase (FPGS) Single Nucleotide<br />
Polymorphism (SNP) Is Associated with Response to Pemetrexed<br />
Treatment for Non-Small Cell Lung Cancer/S. Fukuda, T. Oguri, T.<br />
Uemura, Y. Kanemitsu, O. Takakuwa, H. Ohkubo, M. Takemura, K.<br />
Maeno, A. Niimi, Nagoya City, Japan, p.A3133<br />
322 Arsenic Trioxide Inhibits Cancer Stem Cells Via<br />
Down-Regulation of Hedgehog Pathway in Lung Cancer/B. Li,<br />
M.-H. Yang, K.-J. Chang, Shanghai, China, p.A3134<br />
323 Synergy Between Anti-MARCKS Peptides and<br />
Chemotherapeutic Agents in Attenuation of NSCLC Metastasis<br />
and Tumor Growth Could Be Based on MARCKS Cell Cycle<br />
Regulation/S. Fang, Q. Yin, J. Park, A. Crews, B. Dickson, K.<br />
Adler, Raleigh, NC, p.A3135<br />
324 p16 Controls Lung Epithelial Cell Growth and Suppresses<br />
Transformation Through Mechanisms that Do Not Require<br />
Retinoblastoma (Rb) Function/M. Sen, N. Akeno, A. Reece, D.S.<br />
Simpson, K.A. Wikenheiser-Brokamp, Cincinnati, OH, p.A3136<br />
325 Cigarette Smoke Extract Exposure Induces EGFR-TKI<br />
Resistance in EGFR-Mutated NSCLC Via Mediating Src<br />
Activation and EMT/H. Chen, D. Li, L. Zhang, J. Zhou, Chongqing,<br />
China, p.A3137<br />
P139<br />
P140<br />
P141<br />
P142<br />
Cela1 Promotes Postnatal Alveolar Enlargement and Its<br />
Expression and Binding to Elastin Is Regulated by Stretch/B.<br />
Varisco, S. Liu, R. Joshi, Cincinnati, OH, p.A3142<br />
Overview of Multicenter Genomic Research in Alpha-1<br />
Antitrypsin Deficiency and Sarcoidosis (GRADS) and<br />
Biorepository/T. Adams, T. Woolard, G. DeIuliis, M. Vukmirovic,<br />
X. Yan, N. Aurelien, H. Buqu, H. Lynn, S. O'Neal, M. Becich, H.<br />
Hochheiser, D.R. Moller, K. Gibson, C.B. Strange, R.A. Sandhaus,<br />
R.M. Senior, E.S. Chen, A. Wyllie, A.M. Morris, B. Methe, E.<br />
Ghedin, J.K. Leader, N. Petro, Y. Zhang, L. Silfies, D. Protivnak, M.<br />
Martinez, S.R. Wisniewski, N. Kaminski, New Haven, CT, p.A3143<br />
The Role of Glycosylation of Alpha-1 Antitrypsin in<br />
Inflammation Resolution/D.M. Dunlea, O.J. McElvaney, N. Lacey,<br />
M. White, C. McCarthy, P. Hawkins, E. Reeves, N.G. McElvaney,<br />
Dublin, Ireland, p.A3144<br />
Characterization of the Lung Microbiota of Alpha-1 Antitrypsin<br />
Deficient Individuals/M.E. Kirst, J. Nolte, J. Lascano, F. Rouhani,<br />
M.L. Brantly, Gainesville, FL, p.A3145<br />
THEMATIC POSTER SESSION<br />
B31<br />
THEMATIC POSTER SESSION<br />
ALPHA-1 ANTITRYPSIN DEFICIENCY<br />
9:00 a.m. - 4:15 p.m. MOSCONE CENTER<br />
Viewing: Posters will be on display for entire session.<br />
Area B, Hall D (North Building, Lower Level)<br />
Discussion: 11:00-11:45: authors will be present for individual discussion<br />
11:45-12:45: authors will be present for discussion with assigned facilitators<br />
Facilitator:<br />
P135<br />
P136<br />
P137<br />
P138<br />
C.E. Cross, MD, Sacramento, CA<br />
The Clinical Associations of Aa-Val360 in Alpha 1-Antitrypsin<br />
Deficiency/E.V. Low, P.R. Newby, R.G. Edgar, R.A. Stockley, A.M.<br />
Turner, Birmingham, United Kingdom, p.A3138<br />
A Comparison of the Inflammatory Immune Cell Infiltration<br />
Associated with Lung Tissue Destruction in Panlobular<br />
Emphysema in Alpha-1 Antitrypsin Deficiency and<br />
Centrilobular Emphysema Associated with Smoking/D. Kinose,<br />
D.M. Vasilescu, T.-L. Hackett, W.M. Elliott, F. Chu, S. Verleden,<br />
B.M. Vanaudenaerde, J.D. Cooper, J.C. Hogg, Vancouver, Canada,<br />
p.A3139<br />
PRMT6 Mediates Inflammation, Apoptosis and Oxidative<br />
Stress in a Cigarette Smoke Extract-Induced Mouse<br />
Emphysema Model/X. He, Y. Chen, N. Kang, T. Li, H. Zeng, Z.<br />
Chen, Changsha, Hunan, China, p.A3140<br />
Longitudinal Three-Year Decline in Alpha-1 Antitrypsin<br />
Deficiency: Regional Worsening in Emphysema and<br />
Ventilation/E. Lessard, A. Ouriadov, D. Pike, D.G. McCormack, G.<br />
Parraga, London, Canada, p.A3141<br />
B32<br />
ALVEOLAR MACROPHAGE BIOLOGY<br />
9:00 a.m. - 4:15 p.m. MOSCONE CENTER<br />
Viewing: Posters will be on display for entire session.<br />
Area B, Hall D (North Building, Lower Level)<br />
Discussion: 11:00-11:45: authors will be present for individual discussion<br />
11:45-12:45: authors will be present for discussion with assigned facilitators<br />
Facilitator:<br />
P146<br />
P147<br />
P148<br />
P149<br />
P150<br />
P151<br />
R. Vlahos, PhD, Bundoora, Australia<br />
cFLIP Is Required for the Maintenance of Embryonic-Derived<br />
Alveolar Macrophages/A.L. McCubbrey, L. Barthel, W. Janssen,<br />
Denver, CO, p.A3146<br />
Autoantibody Against GM-CSF Presented by MHC Class II in<br />
Autoimmune Pulmonary Alveolar Proteinosis/Y. Hamano, H.<br />
Kida, M. Hirose, A. Matsumuro, T. Suenaga, H. Sarashina, T.<br />
Hamasaki, Y. Inoue, H. Arase, A. Kumanogoh, Suita, Japan, p.A3147<br />
Recruitment and Proliferation of Macrophage Polarization<br />
States During Allergic Lung Inflammation/C. Draijer, C.E.<br />
Boorsma, E. Post, F. Van Dijk, B.N. Melgert, Groningen,<br />
Netherlands, p.A3148<br />
Rac2 Promotes Alternative Macrophage Activation in Bleomycin<br />
Induced Pulmonary Fibrosis/S. Joshi, A. Singh, S. Wong, M.<br />
Zulcic, V. Craig, J. Hagood, D. Durden, San Diego, CA, p.A3149<br />
FoxO1 Mediates Asthmatic Lung Inflammation by Promoting<br />
Alternative Activation of Pulmonary Macrophages/S. Chung, B.<br />
Reader, J.Y. Kim, Y.G. Lee, M. Karpurapu, M.N. Ballinger, G.Y.<br />
Park, J. Christman, Columbus, OH, p.A3150<br />
Effect of Nintedanib on Pro-Fibrotic and Anti-Fibrotic Cytokine<br />
Release from Alveolar Macrophages in Interstitial Lung<br />
Diseases/F. Bonella, X. Long, X. He, D. Theegarten, T.E.<br />
Wessendorf, J. Guzman, U. Costabel, Essen, Germany, p.A3151<br />
MONDAY MORNING<br />
ATS 2016 • San Francisco
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