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WEDNESDAY • MAY 18 341<br />

10:20 TB Treatment Targets, Vaccines, and Host-Directed Therapies<br />

R. Wallis, MD, Johannesburg, South Africa<br />

10:40 Panel Discussion<br />

D11<br />

BASIC • TRANSLATIONAL<br />

SCIENTIFIC SYMPOSIUM<br />

CME Credits Available: 2.0<br />

ARDS AND INFLAMMATORY INJURY<br />

Assemblies on Allergy, Immunology and Inflammation; Critical Care;<br />

Respiratory Cell and Molecular Biology; Respiratory Structure and<br />

Function<br />

9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />

Room 3006/3008 (West Building, Level 3)<br />

Target Audience<br />

Clinical researchers, basic scientists and clinicians interested in understanding<br />

the inter-dependence between the innate immune response, excessive<br />

inflammation, and acute lung injury/ARDS.<br />

Objectives<br />

At the conclusion of this session, the participant will be able to:<br />

• understand the mechanisms which lead to differing outcomes in ARDS;<br />

• learn and understand the mechanisms contributing to inflammatory<br />

response following ALI.<br />

Acute respiratory distress syndrome (ARDS), the most severe form of ALI, has<br />

a mortality rate of approximately 40%, despite modern ICU care. The<br />

importance of inflammation in initiation and progression of acute lung injury has<br />

been previously established. Inflammasome signaling is critical in the host<br />

defense response to infectious and non-infectious agents known to contribute to<br />

lung pathology. Inflammatory responses are typically initiated by the innate<br />

immune system, leading to the production of IL-1ß and IL-18, which recruit<br />

neutrophils and monocytes to the site of infection. However, these same<br />

cytokines and cells can damage the alveolus and impair respiratory function.<br />

An important goal of this session is to illustrate how data derived from patient<br />

samples and clinically relevant animal models points to a common pathway(s)<br />

and helps to define the basic mechanisms which impacts disease outcomes in<br />

patients<br />

Chairing: C. Hardin, MD, PhD, Boston, MA<br />

T. Cohen, PhD, Gaithersburg, MD<br />

9:00 Bridging Human, Animal and In-Vitro Data<br />

M.A. Matthay, MD, San Francisco, CA<br />

9:20 Airway Responses to Bacterial Pathogens<br />

A.S. Prince, MD, New York, NY<br />

9:40 Regulation of Nod-Like Receptors in Acute Lung Injury<br />

K.M. Ridge, PhD, Chicago, IL<br />

10:00 RAGE and Acute Lung Injury<br />

J. Constantin, MD, PhD, Clermont-Ferrand, France<br />

10:20 Alveolar Epithelial Repair After Inflammatory Injury<br />

R.L. Zemans, MD, Denver, CO<br />

10:40 The Transcription Factor Miz1 in the Lung: Good or Bad?<br />

J. Liu, PhD, Chicago, IL<br />

D12<br />

CLINICAL<br />

SCIENTIFIC SYMPOSIUM<br />

CME Credits Available: 2.0<br />

ADVANCES IN TOBACCO DEPENDENCE<br />

TREATMENT FOR THE HOSPITALIZED PATIENT<br />

Tobacco Action Committee<br />

9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />

Room 130-132 (North Building, Lower Level)<br />

Target Audience<br />

Health care workers treating tobacco dependence and tobacco related disease.<br />

Objectives<br />

At the conclusion of this session, the participant will be able to:<br />

• gain new strategies to initiate a quit attempt for hospitalized smokers;<br />

• become familiar with the tools available to implement a hospital-based<br />

smoking cessation program that includes post-discharge follow up;<br />

• improve smoking cessation rates among hospitalized patients.<br />

Hospitalization marks a unique opportunity to impact the tobacco epidemic. The<br />

effective health care system must consider a number of variables in devising<br />

interventions for promoting abstinence and facilitating transition to outpatient care.<br />

In this session various aspects of tobacco dependence treatment in hospitalized<br />

smokers will be explored. Common obstacles including initial counseling of<br />

resistant patients, personalizing treatment plans, use of technology, and effective<br />

discharge planning will be reviewed.<br />

Chairing: F.T. Leone, MD, MS, Philadelphia, PA<br />

9:00 The Inpatient Tobacco Treatment Consultation<br />

F.T. Leone, MD, MS, Philadelphia, PA<br />

9:25 Implementing Hospital Cessation: The Ottawa Model<br />

S. Gilman, MD, Montreal, Canada<br />

9:50 Initiating NRT and Other Treatments<br />

D. Sachs, MD, Palo Alto, CA<br />

10:15 Transitioning into Post-Discharge Care<br />

S. Pakhale, MD, Ottowa, Canada<br />

10:35 Should We Allow E-Cigarette Use in Hospitals?<br />

D.J. Upson, MA, MD, Albuquerque, NM<br />

D13<br />

There will be a 5-minute discussion after each talk.<br />

MINI SYMPOSIUM<br />

VIRAL INFECTIONS AND ASTHMA: HOST DEFENSE<br />

AND SELF DEFEAT<br />

9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />

Chairing: J.E. Gern, MD, Madison, WI<br />

M.M. Wurfel, MD, PhD, Seattle, WA<br />

T.S. Hallstrand, MD, MPH, Seattle, WA<br />

Room 2005/2007 (West Building, Level 2)<br />

WEDNESDAY MORNING<br />

ATS 2016 • San Francisco

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