Medycyna Wieku Rozwojowego

Nowotwory z∏oÊliwe zlokalizowane w obr´bie jajników
U wszystkich chorych z powik∏aniami, po okresie kilkudniowej terapii polegajàcej,
w zale˝noÊci od potrzeb, na substytucji preparatów krwiopochodnych, poda˝y czynników
wzrostu granulocytów lub antybiotyków, objawy uboczne chemioterapii ustàpi∏y
bez istotnych nast´pstw.
WNIOSKI
Programu TGM 95 okaza∏ si´ bardzo skuteczny w leczeniu z∏oÊliwych guzów germinalnych
zlokalizowanych w jajnikach, nawet w stadiach bardzo zaawansowanych.
PIÂMIENNICTWO
1. Schneider D.T., Calaminus G., Koch S., Teske C., Schmidt P., Haas R.J., Harms D., Gobel
U.: Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell
tumor protocols. Pediatr. Blood. Cancer., 2004, 42, 169-175.
2. Castleberry R.P., Cushing B., Perlman E., Hawkins E.P.: Germ cell tumours. W: Principles
and practice of pediatric oncology (red. Pizzo P.A., Poplack D.G.) Lippincott-Raven Publ., Philadelphia,
New York 1997.
3. Rescola F.J.: Germ cell tumors. Semin. Surg. Oncol., 1997, 6, 29-37.
4. Baranzelli M.C., Kramar A., Bouffet E., Quintana E., Rubie H., Edan C., Patte C.: Prognostic
factors in children with localized malignant nonseminomatous germ cell tumours. J. Clin.
Oncol., 1999, 17, 1212-1218.
5. Mann J.R., Raafat F., Robinson K., Imeson J., Gornall P., Sokal M., Gray E., McKeever P.,
Hale J., Bailey S., Oakhill A.: The United Kingdom Children’s Cancer Study Group’s second
germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children
with malignant extracranial germ cell tumours, with acceptable toxicity. J. Clin. Oncol.,
2000, 18, 3809-3818.
6. Rogers P.C., Olson T.A., Cullen J.W., Billmire D.F., Marina N., Rescorla F., Davis M.M.,
London W.B., Lauer S.J., Giller R.H., Cushing B.: Pediatric Oncology Group 9048; Children’s
Cancer Group 8891.Treatment of children and adolescents with stage II testicular and
stages I and II ovarian malignant germ cell tumors: A Pediatric Intergroup Study—Pediatric
Oncology Group 9048 and Children’s Cancer Group 8891. J. Clin. Oncol., 2004, 22, 3563-3569.
7. Cushing B., Giller R., Cullen J.W., Marina N.M., Lauer S.J., Olson T.A., Rogers P.C., Colombani
P., Rescorla F., Billmire D.F., Vinocur C.D., Hawkins E.P., Davis M.M., Perlman E.J.,
London W.B., Castleberry R.P.: Pediatric Oncology Group 9049;Randomized comparison of
combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose
cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup
study – Pediatric Oncology Group 9049 and Children’s Cancer Group 8882. J. Clin.
Oncol., 2004, 22, 2691-2700.
8. Lo Curto M., Lumia F., Alaggio R., Cecchetto G., Almasio P., Indolfi P., Siracusa F., Bagnulo
S., De Bernardi B., De Laurentis T., Di Cataldo A., Tamaro P.: Malignant germ cell tumors
in childhood: results of the first Italian cooperative study „TCG 91”. Med. Ped. Oncol., 2003,
41, 417-425.
9. Schneider D.T., Wessalowski R., Calaminus G., Pape H., Bamberg M., Engert J., Waag K.,
Gadner H., Gobel U.: Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis
of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96. Clin. Oncol.
2001, 19, 1951-1960.
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