Sažeci 2. Hrvatskog kongresa medicinske biokemije - Klinički zavod ...

Sažeci 2. Hrvatskog kongresa medicinske biokemije
POSTERSKI RADOVI
07 - 13/P3
TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH
DIFFERENT CLINICAL DIAGNOSIS
G. Zaja, B. Polenakovic, C. Simeonova, M. Demirevska, S. Trojacanec-
Piponska
Oxidative stress occurs in most, if not ali human diseases. In order
to determine the role of total antioxidant status (TAOS) in the
pathology of the illness and as a control of the antioxidant therapy,
as a new therapeutic approach we have measured the levels of TAOS
in 204 patients and 25 healthv individuals. For that purpose we had
used tests from the firm "Randox" and the determination was performed
on the Analvser "Cobas Mira Plus" from "Roche Diagnostics
Systems". The patients were divided into five groups: l s group with
cardiovascular diseases (x ± SD = 1,37 ± 0,2), 2 n group with carcinomas
of the gastrointestinal tract (GIT) without metastases (x ± SD
= 2,02 ± 0,49), 3 rd group with carcinomas of the GIT with metastases
(x ± SD = 5,19 ± 1,53), 4 th group with breast carcinoma without MS
(x ± SD = 2,23 ± 0,16) and 5 th group with breast carcinoma with MS
(x ± SD = 5,69 ± 0,82). Reference values for our control group were
determined and they are the following: x ± SD = 1,19 ± 0,15; x ± SD
= 1,19 ± 0,30 or 0,0 to 1,49 mmol/L. The recovery for the tested method
was 104,8% and CV was 12,6%. The test had shown high significancy
(p < 0,001) as compared with the control group in ali the tested groups
of patients, and is recommended as one of the markers for monitoring
and following the clinical progress of illness. It is also useful for
controling antioxidant therapy.
07 - 14/P1
PROKOLAGEN III PEPTID U NOVOROĐENČADI
V. Jagić, B. Koprčina, M. Bosotina, D. Petro
Opća bolnica "Sveti duh", Zagreb
Prokolagen III peptid (P III P) je sastojak vezivnog tkiva koji se
može naći u povišenim koncentracijama u serumu tijekom pojačane
aktivnosti fibroblasta i odlaganja kolagena u organizmu. Njegova koncentracija
je povišena u svim stanjima pojačanog stvaranja vezivnog
170 BIOCHEMIA MEDICA god. 6, br. 1, 1996