Sažeci 2. Hrvatskog kongresa medicinske biokemije - Klinički zavod ...

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Sažeci 2. Hrvatskog kongresa medicinske biokemije SEKCIJSKA PREDAVANJA se poremećaj na genskoj razini, određivanjem mjesta loma na kromosomu. Kloniranjem tih regija otkriveni su geni uključeni u translokacije, definirana je organizacija novonastale regije koja izravno utječe na funciju premještenih ili novonastalih hibridnih gena. Uvođenjem PCR metode, koja omogućuje enzimsku sintezu milijuna kopija specifičnih sekvenca DNA, moguće je određivanjem jedne maligne stanice u IO 5 do IO 6 zdravih stanica. Primjenom ove visoko osjetljive metode, osim dobivanja podataka o prirodi molekularnog poremećaja, moguće je otkriti ostatne maligne stanice poslije završetka terapije, u remisiji bolesti ili u ranim stadijima recidiva bolesti. 66 BIOCHEMIA MEDICA god. 6, br. 1, 1996.
SEKCIJSKA PREDAVANJA Sažeci 2. Hrvatskog kongresa medicinske biokemije S2/1 URGENT MEDICINE AND THE LABORATORY A.M. Kelly Royal Alexandra Hospital, Paisley, UK Urgent medicine demands a fast response from the laboratorv. In the past, the time required to transport, centrifuge, analvse and report results of specimens resulted in unacceptable turn-around times (TAT). Now with the introduction of pneumatic tube svstems for transportation, whole blood analvsers and on-line reporting svstems TATs have been dramaticallv reduced. It has been advocated that off-site laboratories are not required and that the central laboratorv can provide both STAT, critical care and routine services (1). This must be the most cost effective solution. Ideallv the central laboratorv and the radiologv department should be at the hub of the hospital complex and radiating from there the units which require urgent sevices: Accident and Emergencv Unit Special Care Baby Unit Intensive Care Medical Unit (Coronary Care) Intensive Care Surgical Unit Theatres This ideal is rarelv met and it may be that even with state-of-theart transport systems the geographic situation of the acute medical units necessitates an off-site laboratory Turn-around times: Staffes et al (2) claim to have reduced TATs from 15 to 2 - 3 minutes for STAT specimens and from 30 to 5 minutes for routine specimens by the use of custom made request forms and off-site laboratories equipped with rapid assay analysers. Wherever the laboratory is sited 10 minutes should be the target TAT for STAT specimens but many of us still struggle to maintain a 30 minute response throughout the 24 hours. BIOCHEMIA MEDICA god. 6, br. 1, 1996 67
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