Sažeci 2. Hrvatskog kongresa medicinske biokemije - Klinički zavod ...
Sažeci 2. Hrvatskog kongresa medicinske biokemije - Klinički zavod ...
Sažeci 2. Hrvatskog kongresa medicinske biokemije - Klinički zavod ...
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POSTERSKI RADOVI<br />
<strong>Sažeci</strong> <strong>2.</strong> <strong>Hrvatskog</strong> <strong>kongresa</strong> <strong>medicinske</strong> <strong>biokemije</strong><br />
30) with an age limit of 75 - 99 years, x = 79,3 ± 9,38, and the blood<br />
pressure was regulated by hypertensive therapy. Plasma fibrinogen<br />
concentration was measured by thrombine method of Clauss, albumin<br />
concentration by BCG, and plasma viscosity was determined by<br />
plasma viscosimeter of the Frezenius firm. The results obtained were<br />
confronted by a reference group (n = 25) whose blood pressure ranged<br />
within normal limits. In the moment of blood sampling for biochemical<br />
analyses, the cases examined showed blood pressure ranging from<br />
120/70 to 180/100 mmHg (x = 144,78/78,42 ± 36,27/20,8). Elevated<br />
blood pressure had 52,1% of the group. Plasma viscosity values ranges<br />
from 1,08 - 2,29 mPas (x = 1,30 ± 0,23) and those values compared as<br />
to the reference group (x = 1,22 ± 0,05) showed in 54% higher values,<br />
while in 62,5% plasma fibrinogen had pathological values from 2,51 -<br />
6,6 g/L (x = 4,33 ± 1,0). There are data in literature speaking about<br />
some plasma metabolites which are decreasing with the age such as<br />
albumin, while the plasma fibrinogen concentration is increasing. The<br />
interpretation of the biochemical analyses in elderly patients should<br />
be done individually depending on their clinical picture.<br />
01/P11<br />
OSIGURANJE I KONTROLA KVALITETE ZA HPLC<br />
ANALIZE<br />
I. Tramišak, F. Plavšić<br />
Centar za biomedicinska istraživanja KBC Zagreb<br />
Osiguranje kvalitete se bavi procjenom svih analitičkih postupaka<br />
(od skupljanja uzoraka do interpretacije rezultata). Kontrola kvalitete<br />
(QC) je dio osiguranja kvalitete (QA). Zadatak kontrole kvalitete je<br />
potvrda da analitički rezultati - nalazi izdani u nekom laboratoriju<br />
udovoljavaju specifičnim zahtjevima ili potrebama korisnika. U ovom<br />
radu prikazana je jedna od metoda kontrole kvalitete koja ispunjava<br />
i dokumentira zahtjeve za pouzdanom, točnom i preciznom HPLC<br />
analizom. To uključuje validaciju koja pokazuje da metoda u načelu<br />
udovoljava zahtjevima, testiranje aparata koje pokazuje da aparat radi<br />
ispravno i precizno te "test podesnosti sustava" koji pokazuje da su<br />
rezultati dobiveni tom metodom i na tom aparatu, koristeći određenu<br />
kolonu za zadanu analizu točni i precizni, ako se isključe sve pogreške<br />
koje se ne odnose na opremu ili metodu.<br />
BIOCHEMIA MEDICA god. 6, br. 1, 1996 97
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