Sommerakademien der deutschen Stiftung - Studienstiftung.ch

Arbeitsgruppe 2
Towards Integrative Biology – Computational and
statistical Approaches in the ‘Big-Data’ Era
Biological sciences are currently undergoing a transformation from a largely descriptive
to a quantitative science. Novel technologies generate vast amounts of data on hundreds
of thousands of biomolecules at increasing levels of temporal and spatial resolution. This
data is beginning to reveal the complex multi-layered nature of cellular regulation, consisting
of interacting networks of proteins, RNA, metabolites and DNA. In addition, substantial
variation in the behaviour of these networks is being uncovered between tissues,
cancerous and non-cancerous cells, and also between individuals. Mathematical, computational,
and statistical models to analyse this data are still in their infancy. There is thus
an urgent need for new approaches that deal with the data to uncover the basic principles
which underly the complexity and variety of life, and that pave the path to take biology
from a largely descriptive to a quantitative science. This transformation will impact almost
every aspect of industry and human endeavour, from agriculture to pharmaceuticals, to
healthcare, to environmental management, to chemical engineering. As part of the summer
school we will introduce state-of-the-art tools and approaches and outline key challenges
for further research.
Leitung
Teilnehmer
Literatur
Prof. Dr. Dr. Dagmar Iber
Department of Biosystems Science and Engineering, ETH Zürich
Dr. Lachlan J. Coin
Senior Lecturer in Statistical Genomics, School of Public Health,
Imperial College London
Studierende aller quantitativen Fächer (Physik, Mathematik, Computer-
und Ingenieurwissenschaften, Computational Biology,
Bioinformatik); mathematische Grundlagen werden vorausgesetzt
Encode Project Consortium et al., An Integrated Encyclopedia of
DNA Elements in the Human Genome, in: Nature 489, 2012, S.
57-74.
The 1000 Genomes Project Consortium. A Map of Human Genome
Variation from Population-Scale Sequencing, in: Nature 467,
2010, S. 1061-1073.
Jaqaman, K./Danuser, G., Linking Data to Models. Data Regression,
in: Nature Review Molecular Cell Biology 7, 2006, S.813-819.
Tyson, J. et al., Sniffers, Buzzers, Toggles and Blinkers. Dynamics
of Regulatory and Signaling Pathways in the Cell, in: Current Opinions
in Cell Biology 15, 2003, S. 221-231.
Akademie VI St. Johann 65