Invasive breast carcinoma - IARC

lished data suggests a 21% rate of local
recurrence overall, with a 17%, 25% and
27% rate in benign, borderline and
malignant PTs, respectively, and a 10%
rate of metastases overall, with a 0%, 4%
and 22% rate in benign, borderline and
malignant PTs, respectively {1887}. Local
re c u r rence after surgery is stro n g l y
dependent on the width of the excision
margins {186}.
Mammary hamartomas
Definition
A well demarcated, generally encapsulated
mass, composed of all components
of breast tissue.
Epidemiology
Hamartomas occur predominantly in the
peri-menopausal age group, but may be
found at any age, including teenagers
and post-menopausal women.
Fig. 1.154 Hamartoma. Intraparenchymal mass of common breast tissue with well defined margin.
Clinical features
H a m a rtomas are frequently asymptomatic
and only revealed by mammography
{3042}. They are detected in 0.16%
of mammograms {1204}. Ve ry large
lesions can deform the breast. Due to
their well defined borders they are easily
enucleated.
Macroscopy
Hamartomas are round, oval, or discoid,
ranging in size from 1 cm to more than 20
cm. Depending on the composition of the
lesion the cut surface may resemble normal
breast tissue, a lipoma or may be
rubbery and reminiscent of a FA.
Histopathology
Generally encapsulated, this circ u m-
scribed mass of breast tissue may show
f i b rocystic or atrophic changes;
pseudoangiomatous hyperplasia (PASH)
is frequent {446}. The lesion gives the
impression of “breast within breast”. In
adolescents, differentiation between the
appearance of the normal adolescent
breast and FAs or asymmetric virginal
hypertrophy can be difficult. Rare examples
resembling phyllodes tumours, have
been observed {2876}.
Variants of hamartoma
Adenolipoma {867}, adenohibern o m a
{618}, and myoid hamartoma {624} could
all be considered variants of mammary
hamartoma.
Prognosis
The lesion is benign with no tendency to
recur.
Fibroepithelial tumours 103