Invasive breast carcinoma - IARC

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Small cell / oat cell carcinoma, 32 Small cell carcinoma, 32-34, 145, 148, 174, 182, 183, 196, 207, 221, 227, 266, 267, 277-279, 301, 309, 321, 323 Small cell carcinoma of neuroendocrine type, 183, 227 Small cell carcinoma hypercalcaemic type, 145. 182 Small cell carcinoma, pulmonary type, 183 Smooth muscle myosin, 75, 86 Smooth muscle tumour of uncertain malignant potential, 238 Solid neuroendocrine carcinoma, 32 Spangaro bodies, 157 Speckled penis, 357 Spindle cell carcinoma, 37, 88, 92 Spindle cell epithelioma, 307 Spindle cell lipoma, 93 Spindle cell variant, adenomyoepithelioma, 87 Spindle cell variant, squamous cell carcinoma 38 Squamotransitional carcinoma, 268 Squamous intraepithelial lesion, 269, 270, 294 Squamous papilloma, 266, 271, 272, 293, 296 S-T syndrome, 95, 96 ST7, 52 Stellate scar, 83 Sternberg tumour, 216 Steroid cell tumour, 138, 160, 188, 196, 216 Stewart Treves syndrome, 95 STK11, 273 STK15, 51 Stromal hyperplasia, 189, 190 Stromal hyperthecosis, 161, 189, 190 Stromal luteoma, 160, 161 Stromal polyp, 271, 297 Stromal tumour with minor sex cord elements, 152 Stromal-Leydig cell tumour, 158 Struma ovarii, 138, 157, 160, 171, 172 Strumal carcinoid, 171-173 Subareolar duct papillomatosis, 104 Superficial angiomyxoma, 327, 329 Superficial spreading melanoma, 331 Supernumerary ring chromosome, 327 Sustentacular cell, 187 Symplastic leiomyoma, 241 Synaptophysin, 30, 33, 34, 173, 279, 334 Syncytial growth pattern, 28 Syncytiotrophoblast, 164, 167, 168, 186, 207, 251, 252, 254 Synovial sarcoma, 304, 307 Syringoma, 81, 324, 325 Syringomatous adenoma, 104, 105 Syringomatous squamous tumour, 39 T Tamoxifen-related lesions, 230 TBX2, 51 Terminal duct lobular unit (TDLU) 13, 17, 19, 60, 63, 66, 76, 79, 81 Thecoma, 135, 147, 149, 150, 152, 158, 187, 215 Thyroglobulin, 138, 172 Thyroid transcription factor-1, 34 TP53, see Li-Fraumeni syndrome TP73, 52, 352 Transforming growth factor alpha, 58 Transitional cell carcinoma, 140-142, 145, 174, 196, 206, 207, 226, 267, 268, 311, 321, 322, 339, 361 Transitional cell metaplasia, 207, 268, 270, 295 TRAP240, 51 Trastuzumab, 58 Trichilemmoma, 324, 325, 355 Trichoepithelioma, 324, 325 TTF-1 (thyroid transcription factor-1), 34 Tubal epithelial hyperplasia, 209 Tubular adenoma, 84, 87, 300 Tubular carcinoma, 19, 23, 24, 26-28, 35, 73, 105, 336, 338, 356 Tubulo-lobular carcinoma, 24, 346 Tubulovillous adenoma, 300 Tumour associated macrophages, 22 Turcot syndrome, 360 Turner syndrome, 176, 249 U Ubiquitin ligase, 342 Ubiquitin-mediated degradation, 53 Ulex europaeus agglutinin-1, 91 Unclassified sex cord - s t romal tumour, 160 Undifferentiated carcinoma of non-small cell neuroendocrine type, 184 Undifferentiated endocervical sarcoma, 280, 281 Undifferentiated endometrial sarcoma, 233, 234, 236 Undifferentiated ovarian sarcoma, 134, 135 Undifferentiated uterine sarcoma, 236 Undifferentiated vaginal sarcoma, 302, 303 Uterus-like mass, 215 V Vaginal intraepithelial neoplasia (VAIN), 293- 296 Vaginal micropapillomatosis, 296 VATER, 357 Verrucous carcinoma, 267, 294, 316, 317 Vestibular micropapillomatosis, 320 Vestibular papilloma, 316, 320 VHL, see von-Hippel Lindau disease 214, 215 Villoglandular variant, adenocarcinoma, 221, 223, 273 Villous adenoma, 300 VIN, see Vulvar intraepithelial neoplasia Virilization, 152, 156, 188-190 von Hippel-Lindau disease, 212, 214, 215 Vulvar intraepithelial neoplasia (VIN), 316, 318-320, 324 W Walthard cell nests, 144 Warty type, squamous cell carcinoma, 266, 267, 294, 316, 317 Well differentiated papillary mesothelioma, 197, 198 Wilms tumour, 169, 182, 187, 200, 256, 284, 285 Wolffian adnexal tumour, 207, 212, 213, 215 WT1, 200, 202 Y Yolk sac tumour, 137, 138, 156, 163- 166, 168, 170, 215, 246, 256, 287, 288, 309, 333 Z ZNF217, 51 Zymogen-like granule, 45 432 Subject Index
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Previous volumes in this series Kle
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World Health Organization Classific
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Published by IARC Press, Internatio
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CHAPTER 1 Tumours of the Breast Can
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TNM classification of carcinomas of
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Invasive breast carcinoma I.O. Elli
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Rapid growth and greater adult heig
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tives, administrative and clerical
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Grade 1 - well differentiated: 3-5
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ent and this is occasionally extens
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Most melanotic tumours of the breas
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A Fig. 1.22 A Classic invasive lobu
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yet others at 90% {97,2147}. For pr
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Fig. 1.27 Medullary carcinoma. The
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myoepithelial cells in fibro a d e
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A Fig. 1.33 Neuroendocrine carcinom
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Macroscopy Fisher et al. reported t
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Fig. 1.39 Apocrine carcinoma. Note
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cells contain intracytoplasmic lume
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A Fig. 1.50 Carcinosarcoma. A Two a
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A B C Fig. 1.75 Lobular neoplasia.
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Intraductal proliferative lesions F
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A B absence of either microcalcific
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Fig. 1.83 Atypical ductal hyperplas
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A B Fig. 1.88 Large excision biopsy
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unusual variants as well. Using thi
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esemble those identified in invasiv
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A B Fig. 1.97 Microinvasive carcino
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A Papilloma may be subject to morph
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A B C Fig. 1.103 Papillary intraduc
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colour measuring from 0.5 to 12 cm.
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Immunoprofile The cases studied by
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Glycogen-rich, clear cell carcinoma
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Differential diagnosis There may be
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quality metaphase spreads from an i
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Fig. 1.67 Lobular carcinoma of brea
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detectable distant metastasis displ
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detected at a late stage as small t
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Extent of ductal carcinoma in situ
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Benign epithelial proliferations G.
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Fig. 1.112 Microglandular adenosis.
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A Apocrine adenoma ICD-O code 8401/
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A B Fig. 1.128 Adenomyoepithelioma,
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Mesenchymal tumours M. Drijkoningen
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1113,1275}. There is a complex patt
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A B Fig. 1.137 A Lipoma. Intraparen
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Fig. 1.141 Angiosarcoma after breas
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A Fig. 1.144 Mammary osteosarcoma.
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Fibroepithelial tumours J.P. Belloc
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aged women (average age of presenta
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lished data suggests a 21% rate of
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A Fig. 1.157 Syringomatous adenoma
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Malignant lymphoma and metastatic t
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used. Inflammatory conditions in th
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male population both in the USA and
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CHAPTER 2 Tumours of the Ovary and
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Polyembryoma 9072/3 Non-gestational
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Surface epithelial-stromal tumours
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A Fig. 2.04 A Serous borderline tum
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A Fig. 2.06 Serous borderline tumou
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A Fig. 2.10 Invasive peritoneal imp
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Fig. 2.15 Mucinous carcinoma with i
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Fig. 2.20 Mucinous endocervical-lik
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A Fig. 2.28 Mucinous cystic tumour
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early secretory endometrium {2605}.
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IV, 6% {2233}. Patients with grade
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A Fig. 2.37 A This polypoid intracy
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Fig. 2.40 Endometrioid cyst with at
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1 tumours are extremely rare. Almos
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Fig. 2.50 Borderline Brenner tumour
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express thrombomodulin and have bee
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serous and transitional cell carcin
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is yellow to tan with a variable ad
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Genetic susceptibility JGCTs may pr
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Clinical features F i b romas may b
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distinguishes this tumour from the
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A Fig. 2.77 A Retiform Sertoli-Leyd
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Mean ages of 21 and 38 years and me
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Tumours unassociated with PJS form
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mal origin without crystals of Rein
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Germ cell tumours F. Nogales A. Tal
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cases, anisokaryosis has no prognos
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ation may coexist in the same neopl
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Table 2.06 Grading of ovarian immat
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A B Fig. 2.102 A Mature cystic tera
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Diagnostic procedures Elevated urin
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associated with mature teratomas sh
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atives intimately admixed. The germ
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Fig. 2.113 Mixed germ cell-sex cord
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A Fig. 2.116 A Adenomatous hyperpla
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Fig. 2.117 Small cell carcinoma, hy
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Clinical features Adenoid cystic-li
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Histopathology This epithelial tumo
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sis. Corpus luteum of pregnancy has
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Lymphomas and leukaemias L.M. Roth
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Secondary tumours of the ovary J. P
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Occasionally, the colonic adenocarc
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Peritoneal tumours S.C. Mok J.O. Sc
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A B Fig. 2.140 Cystic adenomatoid m
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whelmingly poor {1038,1547,2310}. H
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CHAPTER 3 Tumours of the Fallopian
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TNM and FIGO classification of carc
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Endometrioid adenocarcinoma Endomet
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Two examples of adenofibroma of bor
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A Fig. 3.11 Adenomatoid tumour. A T
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Clinical features Patients range in
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Fig. 3.16 Uterus-like mass. The cys
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CHAPTER 4 Tumours of the Uterine Co
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TNM and FIGO classification of non-
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Epithelial tumours and related lesi
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endometrioid adenocarcinoma fro m a
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fers from the prototypical type I e
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the ovary and bladder. Unlike prima
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schema {1535,2602}. Although this c
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Table 4.03 Altered gene function in
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Mesenchymal tumours and related les
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areas are limited to less than 30%
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A B C Fig. 4.30 Leiomyosarcoma. A T
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e used sparingly and is reserved fo
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A B Fig. 4.38 Leiomyoma with perino
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cytological atypia, tumour cell nec
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Mixed epithelial and mesenchymal tu
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Prognosis and predictive factors Th
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tumours may superficially invade th
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A Fig. 4.46 A Gestational choriocar
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A Fig. 4.49 A Classic complete hyda
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Sex cord-like, neuroectodermal and
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Secondary tumours of the uterine co
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WHO histological classification of
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Epithelial tumours M. Wells J.M. Ne
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Fig. 5.04 Mechanisms of human papil
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Fig. 5.08 Keratinizing squamous cel
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in their Asian population {2957}. I
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have a strong association with high
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e red by squamous epithelium {380}.
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endometrioid adenocarcinoma of the
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metrial epithelium. In some cases t
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with distinct cell borders and a gr
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Mesenchymal tumours M.L. Carcangiu
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{781}, liposarcoma {2840,3016}, ost
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Mixed epithelial and mesenchymal tu
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Fig. 5.44 Wilms tumour. The tumour
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A Fig. 5.47 Implant of endometrial
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CHAPTER 6 Tumours of the Vagina Alt
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Epithelial tumours E.S. Andersen A.
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Aetiology The fact that both VAIN a
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Fig. 6.10 Fibroepithelial polyp.A m
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er of mitoses varies but is usually
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ICD-O codes Adenosquamous carcinoma
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A C Fig. 6.17 Sarcoma botryoides. A
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1-11 cm. They may arise anywhere in
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elsewhere in the female genital tra
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A Fig. 6.24 Yolk sac tumour. A The
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g rowing in sheets. Some may have s
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WHO histological classification of
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Epithelial tumours E.J. Wilkinson M
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even with additional sectioning, it
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type) is a highly diff e rentiated
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Clinical features Bartholin gland c
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glandular elements surrounded by fi
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Mesenchymal tumours R.L. Kempson M.
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Table 7.03 Differential diagnosis o
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Prognosis and predictive factors A
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Table 7.04 Clark levels of cutaneou
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A Fig. 7.23 Vulvar peripheral primi
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Familial aggregation of cancers of
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BRCA1 syndrome Definition Inherited
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dispose individuals to the developm
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Fig. 8.05 To assess whether wild-ty
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Fig. 8.07 Factors that modify risk
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BRCA2 syndrome R. Eeles S. Piver S.
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tubal or ovarian carcinomas. Howeve
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in typical nuclear foci that may re
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Breast tumours Frequency Breast can
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Fig. 8.14 Codon distribution of som
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Breast tumours Age distribution and
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Hereditary non-polyposis colon canc
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essary in the evaluation of the pat
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Age distribution and penetrance Mos
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Contributors Dr Vera M. ABELER** De
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Dr Carlo LA VECCHIA Laboratory of E
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Dr Manuel TEIXEIRA Department of Ge
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02.100 Dr. A. Ostor 02.101 Dr. F.A.
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52. Akhtar M, Robinson C, Ashraf Al
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180. Bapat K, Brustein S (1989). Ut
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307. Bolis GB, Maccio T (2000). Cle
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436. Chang J, Sharpe JC, A'Hern RP,
Page 378 and 379:
562. Costa MJ, Ames PF, Walls J, Ro
Page 380 and 381: 689. Di Domenico A, Stangl F, Benni
Page 382 and 383: 820. Falck J, Petrini JH, Williams
Page 384 and 385: 943. Gad A, Azzopardi JG (1975). Lo
Page 386 and 387: 1067. Grimes MM (1992). Cystosarcom
Page 388 and 389: 1197. Herod JJ, Shafi MI, Rollason
Page 390 and 391: 1323. Jacques SM, Qureshi F, Ramire
Page 392 and 393: 1449. Khalifa MA, Mannel RS, Harawa
Page 394 and 395: 1564. Lagios MD (1977). Multicentri
Page 396 and 397: 1687. Loman N, Johannsson O, Kristo
Page 398 and 399: 1807. McCluggage G, McBride H, Maxw
Page 400 and 401: 1937. Mukai M, Torikata C, Iri H (1
Page 402 and 403: 2056. Norris HJ, Taylor HB (1967).
Page 404 and 405: 2180. Park JS, Jones RW, McLean MR,
Page 406 and 407: 2304. Puls LE, Hamous J, Morrow MS,
Page 408 and 409: 2 4 3 4 . Rosen PP, Groshen S, Saig
Page 410 and 411: 2559. Schlesinger C, Silverberg SG
Page 412 and 413: 2686. Silverberg SG (1999). Protoco
Page 414 and 415: 2806. Stutz JA, Evans AJ, Pinder S,
Page 416 and 417: 2942. Tornos C, Silva EG, Ordonez N
Page 418 and 419: 3061. Wargotz ES, Norris HJ (1990).
Page 420 and 421: 3189. Yoshioka T, Tanaka T (2000).
Page 422 and 423: References 425
Page 424 and 425: Biphasic teratomas, 168 BLM, 341, 3
Page 426 and 427: G GADD45, 343, 353 GCDFP-15, 25, 33
Page 428 and 429: MPNST, see Malignant peripheral ner
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Invasive breast carcinoma - IARC

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