Invasive breast carcinoma - IARC

Clinical findings
The patients typically present with vaginal
bleeding {2354}.
Tumour spread and staging
Most lymphomas and leukaemias that
involve the uterine corpus are a manifestation
of disseminated disease. On rare
occasions the corpus is the first known
site of a malignant lymphoma.
A
B
Fig. 4.57 Sex cord-like tumour. A Several nodules composed of luteinized cells with ample eosinophilic to
vacuolated cytoplasm are present. B The nodule of luteinized cells stains positively for alpha-inhibin.
Histopathology
The majority of cases are of the large B cell
type {114}. Lymphomas of the uterine corpus
must be distinguished from an atypical
lymphoma-like inflammatory lesion of the
endometrium. The latter is characterized
by a massive infiltrate of lymphoid cells,
some of which are immature. The pre s e n c e
of other inflammatory cells including plasma
cells and neutrophils within the infiltrate
and the typical absence of myometrial
invasion or a macroscopic mass are helpful
in the diff e rential diagnosis {851}. Cases
of uterine leiomyoma massively infiltrated
by lymphocytes may also mimic a lymphoma
{488}.
Rare tumours
A
B
Fig. 4.58 Melanotic paraganglioma. A Note the nests of polyhedral cells with abundant clear cytoplasm.
B Tumour cells have uniform nuclei and contain coarse melanin pigment.
Definition
A variety of benign or malignant tumours
of the uterine corpus that are not otherwise
categorized.
granules were present in many cells. The
large cells do not stain with S-100 protein.
At the ultrastructural level intracellular
melanosomes and premelanosomes
abound, and a few neuroendocrine granules
are present; the cells lack microvilli
or dendritic processes.
Prognosis and predictive factors
Both women were free of any recurrences
at 2.2 and 3.2 years after the discovery
of the tumour {2866}.
Lymphomas and leukaemias
Definition
A malignant lymphoproliferative or
haematopoetic neoplasm that may be
primary or secondary.
Histopathology
Germ cell tumours such as teratomas
and yolk sac tumours can develop in the
endometrium, either in a pure form {398,
2196,2763,2836} or associated with
endometrioid tumours {103,2665}.
Extrarenal Wilms tumours (nephroblastomas)
have also been reported in the
uterus {1783,1934}. Their histological
appearance is similar to that of the
tumours occurring in other sites.
256 Tumours of the uterine corpus