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SLEEP 2011 Abstract Supplement

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A. Basic Science XII. Instrumentation and Methodology<br />

two 5-day simulated shift work periods separated by a rest break of one<br />

or two days. 11 subjects were assigned to a day shift condition (daily<br />

TIB 22:00-08:00), whereas 24 subjects were assigned to a night shift<br />

condition (daily TIB 10:00-20:00). In both day and night shift conditions,<br />

each shift work day included four 30min driving sessions, at fixed<br />

intervals over time of day (AM or PM depending on condition). Subjects<br />

drove a simulated Ford Taurus in a standardized scenario of rural highways<br />

in a high-fidelity driving simulator (PatrolSim IV, MPRI, Salt Lake<br />

City, UT). Ten straight, uneventful road segments with a speed limit of<br />

55mph (cumulative driving time ~5min) were designated to extract 87<br />

potential driving performance metrics (72Hz sampling).<br />

Results: The variance in the data set of 35 subjects by 40 driving sessions<br />

by 87 metrics was examined with principal component analysis.<br />

This yielded two dominant dimensions of driving performance, which<br />

were represented by metrics reflecting steering variability and lane<br />

deviation, respectively. The steering dimension explained 39% of the<br />

variance and the lane dimension explained another 9% of the variance.<br />

Mixed-effects ANOVA revealed significant interactions of condition by<br />

time of day for the steering dimension (F=4.26, P

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