SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science I. Sleep Disorders – Breathing
0449
INTERINDIVIDUAL DIFFERENCES IN ENDOTHELIAL
FUNCTION IN OTHERWISE HEALTHY OSA SUBJECTS
Arnardottir ES 1,2 , Thorleifsdottir B 2 , Svanborg E 3 , Olafsson I 4 ,
Gislason T 1,2
1
Department of Respiratory Medicine and Sleep, Landspitali University
Hospital, Reykjavik, Iceland, 2 Faculty of Medicine, University of
Iceland, Reykjavik, Iceland, 3 Department of Clinical Neurophysiology,
University Hospital, Linkoping, Sweden, 4 Department of Clinical
Biochemistry, Landspitali University Hospital, Reykjavik, Iceland
Introduction: The aim of this study was to measure endothelial function
in otherwise healthy obstructive sleep apnea (OSA) patients compared
to controls from the general population and changes following 3
months of continuous positive airway pressure (CPAP) treatment. Endothelial
dysfunction reflects cardiovascular risk and has been found in
OSA subjects with cardiovascular disease.
Methods: Participants underwent a full-night polysomnography. Measurements
of endothelial function were performed in the evening and
morning, measuring reactive hyperemia peripheral arterial tone (RH-
PAT) index. Blood samples were collected for interleukin-6 and leptin
determinations and nocturnal urine for catecholamine measurements.
Results: 35 male subjects (mean age±SD, 48.4±8.6 years, mean BMI
33.2±6.1 kg/m2) were recruited. 17 subjects had mild-to-moderate
OSA (apnea-hypopnea index, AHI =10-30, mean 20.1±6.6), 10 severe
OSA (AHI >30, mean 50.1±14.2) and 8 were controls (AHI