SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science I. Sleep Disorders – Breathing
0347
THE ASSOCIATION OF SLEEP-DISORDERED BREATHING
AND COGNITIVE FUNCTION IS MODIFIED BY THE
APOLIPOPROTEIN E-EPSILON4 ALLELE IN WISCONSIN
SLEEP COHORT STUDY PARTICIPANTS
Nikodemova M 1 , Barnet JH 1 , Salzieder N 1 , Mignot E 2 , Peppard PE 1
1
Population Health Sciences, University of Wisconsin, Madison, WI,
USA, 2 Stanford University, Palo Alto, CA, USA
Introduction: Sleep-disordered breathing is associated with decrements
in cognitive function. Additionally, the Apolipoprotein E-4 (ApoE-epsilon4)
allele is associated with cognitive decrements, as well as greater
risk of SDB. We sought to determine if ApoE-epsilon4 status modifies
the association of SDB with cognitive function in Wisconsin Sleep Cohort
Study participants.
Methods: 765 adult subjects (44% female, age range 30-81 years),
selected from an employed-population sample in 1988, were polysomnographically-assessed
for SDB and also had cognitive evaluations at
4-year intervals (a total of 1857 studies). For this analysis, cognitive
function protocols included the: Symbol-Digit Modalities Test; Auditory
Verbal Learning Test; and Oral Word Fluency Test. ApoE genotype was
determined using the polymerase chain reaction-restriction fragment
length polymorphism method. To test whether ApoE genotype modifies
the association of SDB and cognitive function, linear mixed-effects
models regressed cognitive test scores on: SDB categories (apnea-hypopnea
index [AHI]