SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science IX. Psychiatric and Behavioral Disorders and Sleep
Styles Questionnaire (RSQ), and Obsessive-Compulsive Drinking Scale
(OCDS), and the Insomnia Severity Index (ISI) for insomnia.
Results: Independent of insomnia diagnosis, alcoholics scored higher
on the ISI (p=.001) and OCDS (p=.002), but only the AD-INS group
rated higher than controls on the APSQ (p=.008) and the RSQ (p=.003).
In ADs only, and controlling for insomnia diagnosis, APSQ was significantly
correlated with ISI (R2=.693), RSQ (R2=.525), and with the ‘obsessive
thoughts’ OCDS subscale (R2=.488). RSQ was not correlated
with the ISI or OCDS.
Conclusion: These findings suggest that subjects with AD-INS have
global ruminative thought processes that encompass self-focused depressive
thoughts (RSQ), preoccupation with sleep (APSQ), and preoccupation
with alcohol (OCDS). Conversely, depressive rumination was
not associated with thinking about drinking. Combined, these observations
can be interpreted to indicate that primary insomnia and alcohol
dependence share common cognitive processes that play a role in maintaining
the disorders.
Support (If Any): R37 AA007065-22S1, NIH-NIAAA R01 AA016117,
NIH-NIAAA
0729
SLEEP DISTURBANCES AMONG FORMER HEROIN
ADDICTS WITH AND WITHOUT METHADONE
MAINTENANCE TREATMENT: A CASE-CONTROL STUDY
Lee H 1,2,3 , Chen C 1,2 , Wang S 4
1
Department of Psychiatry, School of Medicine, College of Medicine,
Taipei Medical University, Taipei, Taiwan, 2 Department of Psychiatry,
Shuang Ho Hospital, Taipei Medical University, New Taipei, Taiwan,
3
Sleep Center, Taipei Medical University Hospital, Taipei, Taiwan,
4
Division of Mental Health and Substance Abuse Research, National
Health Research Institute, Miaoli County, Taiwan
Introduction: Poor sleep quality has been reported to be commonly
seen among heroin addicts. Although methadone maintenance treatment
(MMT) could help patients in recovery from heroin dependence, the
majority of MMT patients remained suffering from sleep disturbances.
However, studies in this field have received little attention. Thus, this
study aims to investigate the distributions of sleep disturbances and their
associations with psychological distresses and quality of life among
MMT patients, compared with former heroin addicts without MMT.
Methods: The study cohort included 82 MMT patients. Besides, 88 previous
heroin addicts not receiving MMT were collected for comparison.
All subjects received overnight ECG monitoring at home for the assessment
of cardiopulmonary coupling during sleep. Patients filled out valid
questionnaires including the Chinese Pittsburgh Sleep Quality Index
(CPSQI), the Epworth Sleepiness Scale (ESS), the Insomnia Severity
Index (ISI) and WHO Quality of Life-Brief version (WHOQOL-BREF)
at next morning. Specific sleep disorders and comorbid psychiatric disorders
were assessed by clinical interview.
Results: More than two thirds (67.9%) of MMT patients suffered from
poor sleep quality and one forth (25.6%) of them reported excessive
daytime sleepiness. Compared to patients not receiving MMT, MMT
patients were more likely to have poor sleep quality indicated by higher
mean scores in CPSQI, ESS and ISI. MMT patients reported poorer
quality of life. There were no significant differences in the distribution
of specific sleep disorders and cardiopulmonary coupling during sleep
between former heroin addicts with and without MMT.
Conclusion: Our study indicated that MMT patients were more likely to
suffer from sleep disturbances than previous heroin addicts not receiving
MMT. Furthermore, poor sleep quality among MMT patients could lead
to poor quality of life. The associations between sleep disturbances and
psychiatric co-morbidities were also demonstrated among this specific
population.
Support (If Any): This study was supported by a grant from the National
Science Counsil in Taiwan (NSC 98-2314-B-038-026-MY2).
0730
SLEEP CONTINUITY IS IMPAIRED AS A FUNCTION OF
AVERAGE NUMBER OF DAILY CIGARETTES AND TIME
SINCE SMOKING ONSET IN OTHERWISE HEALTHY
SMOKERS
Soreca I, Conklin C, Richardson A, Mumma J, Wettlaufer B, Curet D
Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Introduction: Cigarette smoking is the most important cause of preventable
morbidity and premature death in the United States. In addition to
adverse effects on respiratory, cardiovascular and cerebrovascular systems,
cigarette smoking may also increase morbidity by impairing sleep.
Most of the empirical evidence on the detrimental effects of smoking on
sleep is based on population surveys and self-report measures. Moreover,
virtually no study to date has investigated the effects of cigarette smoking
on sleep by segregating them from the effects of smoking-related medical
comorbidities, such as sleep disordered breathing. The aims of this study
are 1) to objectively investigate behavioral correlates of sleep by means
of wrist actigraphy in otherwise healthy smokers and 2) explore the relationship
between sleep characteristics and smoking history.
Methods: 10 otherwise healthy smokers, who had been smoking at least
10 cigarettes/day for the past year, wore a wrist actigraph on their nondominant
arm to objectively establish habitual sleep patterns for two
weeks. Time since onset of smoking, maximum amount of cigarettes
per day and current amount of cigarettes per day were derived from the
Smoking History Form (SHF II)
Results: Current average number of cigarettes per day and time since
smoking onset were associated with higher sleep fragmentation index
(r-.86, p=.006 and r=.84, p=.008 respectively) after adjusting for age.
Conclusion: Cigarettes smoking impairs sleep continuity even in the
absence of sleep disordered breathing and other medical comorbidities.
The degree of impairment is related to current severity and duration of
smoking.
Support (If Any): NIDA 1R01DA027508 - 01
0731
EFFECTIVE TRANSLATION OF THE PITTSBURGH SLEEP
QUALITY INDEX INTO URDU
Surani A 1 , Hesselbacher S 2 , Khaliqdina JS 1 , Subramanian S 2 ,
Surani S 2,3
1
Dow University of Health Sciences, Karachi, Pakistan, 2 Section of
Pulmonary, Critical Care, and Sleep Medicine, Baylor College of
Medicine, Houston, TX, USA, 3 Department of Medicine, Texas A&M
University, Corpus Christi, TX, USA
Introduction: The Pittsburgh Sleep Quality Index (PSQI) is a questionnaire
used in English speaking countries for assessment of sleep quality
and disturbances in patients with psychiatric disorders. The instrument
has been translated into many languages; it has not yet been validated in
the Urdu-speaking population. Our purpose was to translate and validate
the PSQI for use in Urdu-speaking countries.
Methods: The original PSQI was translated into Urdu (PSQI-Ur) in
three phases: translation and back-translation, committee-based translation,
and testing in bilingual individuals, before final approval of the
PSQI-Ur version. Subsequently, a prospective study was performed in
healthy bilingual subjects to assess the validity of the PSQI-Ur version
compared to the original PSQI in the English version.
Results: Both English and Urdu versions of the PSQI were administered
to 89 bilingual subjects (67% female, age range 15-70 years) in random
order. The mean (± s.d.) global PSQI score was 5.73 ± 2.54 in English
language and 5.63 ± 2.59 in the PSQI-Ur (p=1.00). The PSQI-Ur score
was highly correlated with the English PSQI (rho=0.944, p