SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science XII. Sleep and Aging
development of MetSyn and potentially contribute to excess CV morbidity
and mortality.
Support (If Any): NIH Fund #5P5OHL083800-02
0895
PILOT STUDY OF CYCLIC ALTERNATING PATTERN (CAP)
NREM SLEEP MICROARCHITECTURE IN PATIENTS WITH
CLINICALLY DIAGNOSED LEWY BODY DEMENTIA AND
ALZHEIMER DISEASE
Pao W 1 , St. Louis EK 1,3 , Ferman T 2 , Lin S 2 , Knopman DS 3 ,
Petersen RC 3 , Boeve BF 1,3
1
Center for Sleep Medicine, Mayo Clinic, Rochester, MN, USA,
2
Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville,
FL, USA, 3 Department of Neurology, Mayo Clinic, Rochester, MN,
USA
Introduction: Cortical brain arousal may be indexed by NREM cyclic
alternating pattern (CAP) sleep microarchitecture, which is thought to
reflect cerebral cortical infraslow oscillatory activity. Slow cortical oscillations
have recently been shown to correlate with cognition, specifically
learning and memory. We aimed to determine whether CAP sleep
rates differed between two subgroups of patients with clinically diagnosed
neurodegenerative disorders: Lewy body dementia (LBD) and
Alzheimer disease (AD).
Methods: Full night diagnostic polysomnographic data of 4 (2 LBD and
2 AD) patients were manually analyzed using Hypnolab CAP scoring
software (ATES Medica Labs, Verona, Italy). CAP sleep index during
diagnostic polysomnography was obtained. All patients have apnea/hypopnea
index 7 minutes; group 2 mean SL > 7 minutes.
Results: There was a significant positive correlation for WPAT correct
answers and mean SL (r = .413, p = .012) after initial learning. There was
a negative trend for an improvement in the number of words recalled 8
hours later and mean SL(r= -.345, p= 0.072). In addition, there was a significant
negative correlation for total minutes of sleep and initial learning
(r= -.575, p=0.000) and a positive trend for total minutes of sleep and
remembering more words at the delayed recall (r=.287, p=0.065).Those
with an average SL > 7 minutes showed a significantly higher recall
after the initial learning (p=0.033) and significantly lower improvement
in delayed recall 8 hours later (p=0.049) than those with an average SL