SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science III. Sleep Disorders – Insomnia
0522
TREATMENT OF PRIMARY INSOMNIA IN THE ELDERLY:
PREDICTORS OF RESPONSE TO ESZOPICLONE
Marshall RD 1 , Grinnell T 1 , Zummo J 1 , Schweizer E 2
1
CRMA, Sunovion Pharmceuticals Inc., Marlborough, MA, USA,
2
Paladin Consulting Group, Hoboken, NJ, USA
Introduction: Chronic sleep disturbance is highly prevalent in the elderly.
This analysis aimed to identify predictors of response to treatment
with eszopiclone in elderly patients (65-85 years of age) with insomnia.
Methods: A post-hoc, multivariate logistic regression analysis was performed
on ITT week 12 LOCF (endpoint) data comparing eszopiclone
2 mg to placebo for insomnia in a cohort of previously studied elderly
outpatients diagnosed with insomnia (n=388). Treatment response was
defined as ≥50% reduction from baseline in sleep latency (SL) or wake
time after sleep onset (WASO); or >30 minute increase from baseline in
total sleep time (TST). Covariates included demographic and baseline
clinical variables, and odds ratios (OR) with confidence intervals were
calculated for each potential predictor.
Results: Treatment group (eszopiclone 2 mg vs placebo) was the only
factor found to influence all 3 response variables (range OR=2.31 to
3.14; p